This will soon be online as #preprint. Collaboratively, our first attempt to understand #tumor #response upon #oncolytic #virus #TVEC #therapy in #melanoma by a brilliant student in our lab

Oncolytic adenovirus delivery of neoantigens sensitizes low-mutation tumors to anti-PD-1 therapy and prevents metastasis

NeoViron, an engineered #oncolytic #adenovirus coexpressing neoantigens and Flt3L, boosts antigen presentation, T-cell infiltration and immune memory, sensitizing low-mutation tumors to #immunotherapy. @fudan-university.bsky.social
#OpenAccess in #STTT: doi.org/10.1038/s413...

This study presents NeoViron, an engineered #Oncolytic virus that concurrently amplifies #TumorNeoantigens, recruits cDC1s, and generates T-cell memory—establishing a new paradigm for overcoming #Immunotherapy resistance in low-TMB tumors.

#OpenAccess: doi.org/10.1038/s413...

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#WOMEN IN #THE #ISRAEL #DEFENSE #FORCES
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#ONCOLYTIC #VIRUS
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#LYNETTE #ROBERTS
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Researchers highlight #oncolytic #HerpesSimplexVirus (HSV-1) viruses as promising #CancerImmunotherapies, detailing advances in #glycoprotein retargeting, discussing molecular entry mechanisms, clinical successes, and future challenges.

#OpenAccess: doi.org/10.1016/j.ge...

The anti-virus T cell response dominates the anti-cancer response in oncolytic virus therapy Oncolytic viruses have strong potential as immunotherapies. By causing cancer cells to die and relieve antigens, these viruses can stimulate robust, systemic immune responses that may eliminate…

Oncolytic viruses looked promising, but trials showed they could not eradicate metastasis. New experiments reveal why: they prime T cells against the virus, not the cancer.

#cancer
#immunotherapy
#oncolytic

buff.ly/faTnvij

Innovative oncolytic virus and immunotherapy combinations pave the way for advanced cancer treatment The integration of oncolytic viruses (OVs) with immunotherapy is reshaping the landscape of tumor treatment, offering new hope for patients. This cutting-edge approach harnesses the ability of OVs to…

Innovative #oncolytic #virus and #immunotherapy combinations pave the way for advanced #cancer treatment ...

| #tumor | #immuneresponse | #vaccines | #cytokines | Via eurekalert .org

This review explores the breakthroughs, challenges, and future directions in engineering receptor-retargeted #oncolytic #Herpes simplex virus-1, promising novel #therapeutic strategies for metastatic and refractory #cancers. #medsky
#OpenAccess:
www.sciencedirect.com/science/arti...

Engineered bacteria launch and control an oncolytic virus - Nature Biomedical Engineering CAPPSID relies on an engineered S. typhimurium to act as a synthetic ‘capsid’ to transcribe and deliver viral RNA inside cancer cells, launching a virus that can directly lyse surrounding cells.

#S. typhimurium were designed to deliver and release self-replicating #oncolytic viral #RNA into #tumor host cells, eventually killing them. go.nature.com/4msnYlB [open access]

Oncolytic immunotherapy with nivolumab in muscle-invasive bladder cancer: a phase 1b trial - Nature Medicine In a phase 1b trial, treatment of patients with muscle-invasive bladder cancer with intravesical oncolytic virus cretostimogene grenadenorepvec in combination with nivolumab was safe and led to encour...

#Oncolytic #adenovirus scoring a big hit on bladder cancer!
www.nature.com/articles/s41...