Following the publication of this study in JASN, there was an interesting correspondence (see Pabla et al JASN 2024 and authors reply Pyne et al JASN 2024). Pabla et al point out that the organic cation transporter 2 (OCT2, encoded by the SLC22A2 gene) is involved in the basolateral tubular uptake and subsequent secretion of creatinine. PPIs may inhibit OCT2 (Nies et al PLoS One 2011). So Pyne et al, in their reply, present some additional analyses that suggest that the effect of pantoprazole compared with placebo on rate of eGFR change was attenuated in patients who discontinued treatment before eGFR reassessment (−0.04 ml/min per 1.73 m2 per year, 95% CI, −0.26 to 0.17) compared with those who remained on treatment (−0.60 ml/min per 1.73 m2 per year, 95% CI, −0.85 to −0.34). This disparity could support a reversible effect of pantoprazole on eGFR, possibly due to inhibition of creatinine secretion, or reflect a dose-response or threshold exposure effect. The case for PPIs causing kidney churn becomes even more weaker. For a longer explanation, see Lonnie Pyne’s rounds here.

Do PPIs cause kidney damage?

Read an update at the bottom of our summary www.nephjc.com/news/compass...

#MedSky #NephSky #EMIMCC

In this case, do you think simultaneous measurements of cystatin C will make the picture clearer?

Sibeprenlimab’s Approval Ushers in New Era for IgAN Treatment | Docwire News Researchers Vlado Perkovic, MBBS, PhD, and Dana Rizk, MD, are featured in a discussion of sibeprenlimab and other B-cell therapies for IgA nephropathy (IgAN).

🔗 www.docwirenews.com/post/sibepre...
Vlado Perkovic and Dana Rizk weigh in on the promise of sibeprenlimab for IgA nephropathy. #nephrology #igan #iganephropathy #nephsky

Targeted-release budesonide dose tapering with reported adverse effects. HbA1c: haemoglobin A1C; WBC: white blood cells; URTI: upper respiratory tract infection.

Is targeted release budesonide really free of systemic steroid action?

In the CKJ academic.oup.com/ckj/article/... Adrenal insufficiency after Nefecon withdrawal

Visual abstract from Edgar Lerma

Another LBCT simultaneous pub at #ISNWCN

A CONFIDENCE mediation analysis in @asnpublications.bsky.social #JASN

journals.lww.com/jasn/fulltex...

VA by @edgarvlermamd.bsky.social

Cheeky billboard in Chennai,India outside US consulate 😁
Who knows, maybe easing that kind of blockade might put him in a good mood after all.

Maple syrup under a microscope.

That is why Canadians are so happy, we literally eat glitter. 😊

#Canada

#gardeningfeed sunday mornings!

The draft of the @kdigo.org 2026 Clinical Practice Guideline for Acute Kidney Injury and Acute Kidney Disease is now available for public review through 🗓️ April 27, 2026
#ISNWCN 🇯🇵 #WCN26 🇯🇵 #WCN2026 🇯🇵
#Nephpearls #NephSky

👉 kdigo.org/guidelines/a...
👉 FEEDBACK Form www.surveymonkey.com/r/GTGNFHG

A viral dog rescue from 2016 is now immortalized with a statue in Kazakhstan. When a dog fell into the Sayran reservoir, bystanders formed a human chain to pull him to safety. The statue is a reminder of the value of unity, solidarity and collective action. 14/10 for all

The IgAN Nephropathy curriculum provides a comprehensive review of the pathogenesis, treatment, and prediction of disease progression to help clinicians in their work.

Access the new curriculum, supported by Otsuka: https://bit.ly/3PirS4N

Am sure you'll bleed just to know you're alive..

#gardening കൊന്നപ്പൂവ് Golden shower tree, Cassia fistula
#keralavishu harvest season

Gamification meets TB -- a free arcade game for World TB Day!!

Jason Madhosingh's wife is a TB doc, and he built this game in her honor!

You can shoot at Mycobacterium tuberculosis and prevent them from destroying lungs!

Please share and make it go viral!!

tberadicator.com

Kaplan-Meier plot showing the relative bleeding risk between rivaroxaban and apixaban over 90 days, clear separation and clearly higher risk from rivaroxaban

The end of the road for rivaroxaban? Shows how important direct comparative trials among drugs within the same pharmacologic class are. #emimcc #cardiosky www.nejm.org/doi/full/10....

A Randomized Trial of Targeted Hyponatremia Correction in Hospitalized Patients Chronic hyponatremia is associated with adverse outcomes, including falls, neurocognitive disorders, and mortality, but whether hyponatremia itself increases morbidity and mortality, or is simply a...

The HIT (Hyponatremia Intervention Trial) is finally out!
#hyponatremia #nephrology

evidence.nejm.org/doi/10.1056/...

Garden flowers

An image on a yellow background featuring a spotlight on text announcing "2 weeks left until World Kidney Day 2026, Thursday 12 March." There is a hashtag that reads "#KidneysMatter" in the lower left corner.

Not long to go!🌟

To get involved, head to the World Kidney Day UK website to download video call backgrounds and lots more!

We'd love your help in spreading the kidney facts and dispelling the myths!

https://www.worldkidneyday.co.uk/get-involved/

#WorldKidneyDay #KidneysMatter

Most of our Primary Health Centres give it free of charge for nephro patients, so difficult to find use for PHIs outside of ESA nonresponse.

Nature run or track run? Nature run, anyday!

#eveningrun

Thank you

Is this with a good handlens?

😁

Any chance recordings gonna be available online?

All the best! Hope it turns out to be good for you👍

#morningrun getting better. I think.

#morningrun getting better. I think😀

Yep.. guilty. Feels so good when i get my fingers on them keys