Beautiful work on paternal behavior in mice 🐭

So excited to be leading this project combining transcriptional reprogramming and cutting-edge optical nanomaterials🧬 🧠

Grateful for the support from @mti-ucb.bsky.social Parkinson's Therapeutics Program as we work to shift the paradigm from dopamine replacement to circuit restoration.

A food-sensitive olfactory circuit drives anticipatory satiety - Nature Metabolism The authors describe a sensory circuit involving the medial septum (MS), where MS glutamatergic neurons integrate food odours to prime satiety and regulate nutrient intake.

A new role for my favorite neuronal population ❤️

Food perception increases the activity of MS glutamatergic neurons, independent of palatability.

Amazing work from the @sophiesteculorum.bsky.social lab!

www.nature.com/articles/s42...

In vivo multiplex imaging of dynamic neurochemical networks with designed far-red dopamine sensors Dopamine (DA) plays a crucial role in a variety of brain functions through intricate interactions with other neuromodulators and intracellular signaling pathways. However, studying these complex netwo...

Excited to share our Science paper on HaloDA1.0-the first genetically encoded far-red dopamine sensor! 🥳It enables powerful multiplex imaging in neurons, brain slices, and live animals.🧠🔬 #GRABsensors #Dopamine www.science.org/doi/10.1126/...

Too excited not to share this beauty!
#fluorescenceFriday (but a day earlier)

TH staining in cyan
Virus injection in magenta

Zona Incerta is definitely a tough cookie 🍪 but getting there!

Reward integration in prefrontal-cortical and ventral-hippocampal nucleus accumbens inputs cooperatively modulates engagement - Nature Communications Neural circuit mechanisms underlying integrating information about reward across time are not fully understood. Here, the authors show that common outcome-integration signals from the medial...

Thrilled to see this part of my PhD work with @rcbagot.bsky.social now out in @natcomms.nature.com!
(1/14)

www.nature.com/articles/s41...

Don’t miss @handejong.bsky.social latest work at #cosyne2025 this Saturday!

Featuring wireless fiber photometry in a brand new foraging task 🪤 and discounted future value modeling in different accumbens subregions!

Changes in neurotensin signalling drive hedonic devaluation in obesity - Nature In mice, prolonged consumption of a high-fat diet decreases interest in calorie-rich foods as a result of reduced neurotensin expression and signalling, which uncouples hedonic feeding behaviour linke...

The latest work from the Lammel lab is out today!

Discover how changes in neurotensin signaling from the NAc Lat to the VTA lead to food devaluation in a mouse model of obesity 🧀🐭

www.nature.com/articles/s41...

elifesciences.org/reviewed-pre...

This looks so so cool, cannot wait to read it! 🤯

“Dopaminergic mechanisms of dynamical social specialization in mouse microsocieties”

www.biorxiv.org/content/10.1...

A Neuropixels Opto probe with 3 blue emitters and 3 red emitters lighting up in succession, with corresponding neural activity in different layers of the cortex.

Neuropixels and Optogenetics are delighted to announce the birth of

Neuropixels Opto

Combining high-resolution electrophysiology and optogenetics

Today in bioRxiv

960 sites, 28 emitters, 2 colors

By Lakunina, @karolinazsocha.bsky.social, Ladd, et al

www.biorxiv.org/content/10.1...

(1/2)

Huge thanks to Drew Kesner for organizing this panel—despite being Bluesky-less! Wishing the NIH situation was different so he could join us. ⛰️

Day 5 at #wcbr2025 – don’t miss our panel!

Join us at 4:30 PM for a session fully dedicated to the medial #septum : inputs, outputs, and role in #motivation & #cognition. 🧠

Excited to share the stage with @smikulovic.bsky.social, @eliftuncozcan.bsky.social, and Dave Bortz. 👩‍🔬👨‍🔬

Day 3 at #wcbr2025 - lots of dopamine, acetylcholine, dorsal and ventral striatum, midbrain circuits and motivated behaviors. Learning so much from such a diverse group of scientists from single dendrite in vivo 2P imaging to high density recordings and modeling 🧠🤯 the field is moving so fast!

Kicked off the first day at #WCBR with an amazing plenary from Suzanne Dickson on #ghrelin, #hunger signaling and its effect on #hypothalamic and #midbrain circuits 🧠

Amazing science in an amazing venue! 🤩

Is #Fluorescence Tuesday a thing?

Still trying to improve the staining protocol, but love this pic of SN #neurons 🔬🧠🐭

Useful resource for 2025 neuro meetings!

Wow!

Thrilled to share that I’ve been awarded an EMBO postdoctoral fellowship to study nigrostriatal axon regeneration and Parkinson’s disease in the Lammel lab at UC Berkeley 🧠🔬

Grateful for this amazing opportunity and excited to join the EMBO fellows community! 🤩

@norambr.bsky.social !

Congrats Sabine! 🤩

Me 🙋🏻‍♀️

Help #neurosky #neuroskyence

Are you (or do you know) someone studying the transcription factor Ascl4/Mash4? 🧠 #neurodevelopment #differentiation #neurons #wiring

N.b. This is not the same as the acyl CoA synthetase protein ASCL4

I have some questions 💡

Please share! 🙏

Me too 🙋🏻‍♀️

3️⃣ Within the GABAergic population, we identified 6 subclusters in the continuum.

These include:
- PV+ and calretinin+ neurons, confirming prior observations
- NPAS1+/Sst+ neurons, which form a distinctive subpopulation
- Nts expressing neurons, adding to the complexity of the GABA population

4/4

2️⃣ ChAT-expressing neurons are better described along a transcriptomic continuum with two distinct endpoints:

- one predominantly expresses Galanin, a neuropeptide largely underexplored
-one co-expresses GABAergic machinery, aligning with the previously reported ChAT-GABA co-releasing neurons

3/n

Key findings:

1️⃣ Gad1 and Gad2, traditionally considered specific to GABAergic neurons, also show unexpected expression in ChAT and VGluT2-expressing neurons, challenging established assumptions about neuronal markers in the MSDB.

2/n

Neuronal heterogeneity in the medial septum and diagonal band of Broca: classes and continua The medial septum and diagonal band of Broca (MSDB) is known for its diverse populations of cholinergic, GABAergic, and glutamatergic neurons, each contributing to various cognitive processes. However...

🦋 Excited to share our newest preprint! 🧠

In this study, we explored the neuronal heterogeneity of the mouse medial septum and diagonal band of Broca using scRNA-Seq + validated our findings by comparing them to a MERFISH dataset from the Allen Brain Atlas.

1/n

www.biorxiv.org/content/10.1...

3️⃣ Within the GABAergic population, we identified 6 subclusters in the continuum.

These include:
- PV+ and calretinin+ neurons, confirming prior observations
- NPAS1+/Sst+ neurons, which form a distinctive subpopulation
- Nts expressing neurons, adding to the complexity of the GABA population

4/4

2️⃣ ChAT-expressing neurons are better described along a transcriptomic continuum with two distinct endpoints:

- one predominantly expresses Galanin, a neuropeptide largely underexplored
-one co-expresses GABAergic machinery, aligning with the previously reported ChAT-GABA co-releasing neurons

3/n