📅 Webinar reminder!
Join us this Friday for @kjarmache.bsky.social webinar.
More details below, or you can register here for free: us06web.zoom.us/webinar/regi...
@activemotifusa.bsky.social
Hands up if you love chromatin & structural biology 🙋♂️
On Friday April 24th we will be joined by @kjarmache.bsky.social from NYU for his webinar 'Chromatin-Modifying Complexes in Gene Activation and Silencing'.
Register here: us06web.zoom.us/webinar/regi...
@activemotifusa.bsky.social
Are you chromat-in or chromat-out? 🧬
Less than 2-weeks left to submit your abstract for this years @aicc-ireland.bsky.social symposium in @ucddublin.bsky.social ! We will be choosing talks & posters from these abstracts to present - with some fantastic prizes available.
Registration link below 👇
Reminder about this exciting webinar from Karen Adelman on later today! 🍿
Registration details below 👇
@activemotifusa.bsky.social
Only 3 weeks left to get your abstract submitted for this years AICC symposium in @ucddublin.bsky.social Conway Institute! 🧬
We will be selecting speakers and posters from these abstracts with prizes up for grabs thanks to our generous sponsors! 🏆
allirelandchromatinconsortium.ie/annual-meeti...
Very excited for this webinar on Friday from Karen!
Join us for the free @aicc-ireland.bsky.social webinar by following the registration details below.
⏰ Calling all chromatin aficionados!
We we will be joined by @adelmanlab.bsky.social from @harvardmed.bsky.social for our March 27th webinar 📅
Karen will be sharing her groups work on 'Transcription & RNA Quality Control in Health & Disease' 😷🧬
Register here: us06web.zoom.us/webinar/regi...
1/ 🧵 In our new paper, we show that JARID2 and PALI1 mimic H3K27me3 to antagonise PRC2. www.cell.com/molecular-ce...
Webinar reminder ⏰
Next Friday join us for @brianstrahl.bsky.social - from @uncchapelhill.bsky.social - webinar on 'Chromatin at the Crossroads of Gene Regulation and Genome Integrity'.
Don't miss out! See registration details below!
us06web.zoom.us/webinar/regi...
@activemotifusa.bsky.social
Please join us for this free @aicc-ireland.bsky.social event in @ucddublin.bsky.social, Dublin!
Great chance to build the Irish nuclear and chromatin biology network and share your research! 🧬
allirelandchromatinconsortium.ie/annual-meeti...
We are excited to be bringing you two webinars from world leaders in epigenetics this month! 🧬
📅Feb 13th- Edith Heard from @crick.ac.uk
📅Feb 27th- @brianstrahl.bsky.social from @uncchapelhill.bsky.social
Don't miss out! See registration details below!
@activemotifusa.bsky.social
Just one week to go until Edith Heard will be joining us for the All-Ireland Chromatin Consortium webinar on 'The Epigenetic Dynamics of X Inactivation in Development and Disease' 🧬
Registration link: us06web.zoom.us/webinar/regi...
Webinar reminder ⏰
Our first All-Ireland Chromatin Consortium webinar of the year, presented by Dr Lucas Farnung, is coming up this Friday at 4pm 📅 . Free registration details below, as well as links to download our new webinar calendar 👇
Super line-up of chromatin, epigenetics and gene regulation speakers coming your way from @aicc-ireland.bsky.social over the next 5 months!
🚨 Multiple #PhD opportunities for lab or computational applicants. Do you want to understand the molecular basis of #epigenetic dysfunction in human disease?
Come work with our group at the fantastic, collaborative @uoe-igc.bsky.social in a beautiful, liveable city.
🧵 1/4
Please repost 🙏
RESEARCH PAPER: Dominant-negative effects of Weaver syndrome-associated EZH2 variants
By Deevy et al., Eric Conway and Adrian Bracken
➡️ https://genesdev.cshlp.org/content/39/21-22/1355.full
Eric Conway
Adrian Bracken
#weaversyndrome #ezh2 #polycomb #mutation #congenitaldisorder #onthecover
Finally, I contend that my artistic capabilities 👨🎨 are also excellent having come up with the original concept art (below) which Gina used as a guide. Give us your opinions on who you think did it best 😅 !
It illustrates the critical balance (Yin-Yang) of EZH2 activity in directing H3K27me in Weaver and growth-restriction syndromes. The resulting opposing impacts on EZH2 coincide with reciprocal impacts on transcription and chromatin organisation. This ultimately blends into chromatin/DNA 'Weave'. ☯️
We are delighted that @genesdev.bsky.social have selected our (w/ @adrianbracken.bsky.social) Weaver syndrome paper artwork as the November cover! This piece was made by my incredibly talented niece, Gina 'Dna Vinci' Ronan.
@ucddublin.bsky.social @tcddublin.bsky.social @ucd-sbbs.bsky.social
Paul Nurse describing the main job of a PI
(From ‘The Thinking Game’, 2024)
1/ 🚀 AEBP2 isn’t what we thought.
You were told that AEBP2 promotes PRC2 activity on chromatin.
We found the opposite: the most prevalent AEBP2 isoform inhibits PRC2 activity.
👉 surl.li/cgwqcq
A thread 🧵
Second annual Conway/ Coughlan lab pumpkin carving competition this morning with plenty of coffee and treats to keep us going! Skills getting better every year.
Can anyone spot the nucleosomes?
@coughlan-lab.bsky.social
@ucddublin.bsky.social
@ucd-sbbs.bsky.social
Absolutely delighted to share our preprint, using functional genomics to uncover a novel dependency in lymphoma that can overcome resistance to targeted therapy. Grateful to co-first author @jamesnolan.bsky.social and co-senior authors @conwayer1.bsky.social and @adrianbracken.bsky.social see👇
🧵1/Exciting news in cancer epigenetics! Our latest research, "AEBP2-Directed H3K27me2 Defines a Specific Vulnerability in EZH2-mutant Lymphoma", is now available on www.biorxiv.org/content/10.1.... Here's a thread summarizing our findings!👇
#CancerResearch #Epigenetics #Chromatin #Lymphoma
Our very own Evan Matthews, from @coughlan-lab.bsky.social, will be running the Dublin Marathon this month in aid of the Irish Cancer Society!
If you want to show Evan and the ICS your support you can donate through the link below!
eventmaster.ie/fundraising/...
@ucddublin.bsky.social
🏃💨
There's a super line up next March for the Keystone meeting in Geneva for anyone interested in chromatin and epigenetics! Not a bad spot for a Spring trip!
🧬👇🇨🇭
#KSEpigenetics26 #epigenetics #chromatin #KeystoneSymposia
We are looking for a student to continue our work on chromatin evolution:
www.nature.com/articles/s41...
www.biorxiv.org/content/10.1...
The project with @seanamontgomery.bsky.social will focus on chromatin state readers across eukaryotes.
More info: recruitment.crg.eu/content/jobs...
👏 Congrats to @conwayer1.bsky.social on a major @genesdev.bsky.social publication!
In collab with @adrianbracken.bsky.social @tcddublin.bsky.social & Dr Orla Deevy @ucdscience.bsky.social, the team showed how EZH2 mutations disrupt PRC2, driving Weaver syndrome🧬
📖 Read more here ▶️bit.ly/3HL0YiI
Delighted that our work on EZH2 dominant negativity in Weaver syndrome is now out in Genes & Development!
This exciting work on chromatinopathies 🧬 was in collab with @adrianbracken.bsky.social and spearheaded by Orla Deevy.
@ucddublin.bsky.social @ucd-sbbs.bsky.social
www.ucd.ie/newsandopini...
