New Epigenome Technologies Blog bit.ly/4uPGRmW

Does an Epigenetic Mechanism Provide a Novel Means of Improving Mesenchymal Stem Cell-based Therapies?

Based on a bioRxiv preprint from Lauren Monroe from the theghoshlab.bsky.social

#Epigenetics #Blog #EZH2 #MSCs

Epigenetics Update - The conserved N-terminal SANT1-binding domain (SBD) of EZH2 regulates PRC2 activity bit.ly/460jVa1

Agata L. Patriotis (Rockefeller University) reporting in Genes Dev

#Epigenetics #EZH2 #PRC2
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Perfect for cancer, immunology, and aging research; epigenometech.com

Epigenetics Update - EZH2 directs HER2+ breast cancer progression through the modulation of epithelial plasticity bit.ly/4qOfmYw

William J Muller (McGill University) reporting in EMBO Rep

#Epigenetics #EZH2 #BreastCancer
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Perfect for cancer, immunology, and aging research; epigenometech.com

RESEARCH PAPER: Dominant-negative effects of Weaver syndrome-associated EZH2 variants
By Deevy et al., Eric Conway and Adrian Bracken
➡️ https://genesdev.cshlp.org/content/39/21-22/1355.full

Eric Conway
Adrian Bracken

#weaversyndrome #ezh2 #polycomb #mutation #congenitaldisorder #onthecover

Restoring order to dividing breast cancer cells may prevent metastasis – BioNews Central The enzyme EZH2 drives abnormal division in triple-negative breast cancer cells, and drugs that inhibit EZH2 can restore normal cell division and prevent metastasis. ...

The enzyme #EZH2 drives abnormal division in #TripleNegativeBreastCancer cells, and drugs that inhibit EZH2 can restore normal #CellDivision and prevent #metastasis.
#BreastCancer #Epigenetics

Inhibitors of the Histone Methyltransferases EZH2/1 Induce a Potent Antiviral State and Suppress Infection by Diverse Viral Pathogens Epigenetic regulation is based on a network of complexes that modulate the chromatin character and structure of the genome to impact gene expression, cell fate, and development. Thus, epigenetic modul...

Inhibitors of the Histone Methyltransferases EZH2/1 Induce a Potent Antiviral State and Suppress Infection by Diverse Viral Pathogens #EZH2 #MECFS #LongCovid

www.ncbi.nlm.nih.gov/pmc/articles...

Ebastine impairs metastatic spread in triple-negative breast cancer by targeting focal adhesion kinase We sought to investigate the utility of ebastine (EBA), a second-generation antihistamine with potent anti-metastatic properties, in the context of breast cancer stem cell (BCSC)-suppression in triple...

Ebastine impairs metastatic spread in triple-negative breast cancer by targeting focal adhesion kinase #STAT3 #ERK1 #ERK2 #MMP2 #MMP9 #EZH2 #MECFS #LongCovid

pmc.ncbi.nlm.nih.gov/articles/PMC...

#CancerResearch #Chromatin #EZH2 #PRC1 #PRC2 #Quiescence #EZH2Inhibitors