Deltaviruses spread through a viral Trojan Horse Hepatitis D-like satellite viruses, known as deltaviruses, have been recently discovered in a wide range of animals. These viruses are thought to expr…

The Trojan Horse is real, and it’s microscopic! 🐴🦠
Our paper is out today in @cellcellpress.bsky.social!
We discovered that deltaviruses physically hide INSIDE helper viruses to sneak into new cells. And to prove it, we had to image them from every angle. 🧵👇

www.sciencedirect.com/science/arti...

Université Grenoble Alpes has opened a full professorship in microbiology. The selected candidate will develop their research program on quantitative approaches in microbiology in the Laboratoire Interdisciplinaire de Physique. For more information 👉🏻 liphy.univ-grenoble-alpes.fr/sites/defaul...

Ground-breaking studies reveal the mechanism of "natural CRISPRa" 🤩

Looking forward to seeing all the technological applications !

🎉 We are thrilled to share our latest study revealing a new mechanism by which Legionella pneumophila evades antibiotic killing via reversible genetic variation mediated by integrative and conjugative elements (ICEs).
📖 Here for the full story:
www.biorxiv.org/content/10.6...

Caspase-4 binds to LPS membranes with positive curvature for non-canonical inflammasome activation The cytosolic LPS sensor caspase-4 controls antibacterial immunity by inducing pyroptosis and cytokine secretion. Began et al. show how remodeling of LPS membranes by interferon-induced GTPase GBP1 pr...

PAPER ALERT!
I am excited to share that our study describing the molecular mechanism of caspase-4 activation has just been published in Immunity.
www.cell.com/immunity/ful...

I would like to thank all the co-authors for their valuable contributions.
Well done guys!
Link for short summary below👇

IRF2 deficiency disrupts pyroptosis, NK cell interferon-γ production and resistance to Francisella - EMBO Reports IRF2 plays an indirect role in inflammasome activation by regulating Caspase-4 and Gasdermin D (GSDMD) levels. However, the in vivo relevance of this regulatory circuit is unknown. We generate IRF2KO ...

IRF2 regulates both GSDMD expression and NK cells antibacterial functions. Check the latest paper from the lab @ciri-lyon.bsky.social published in @emboreports.org. IRF2 as a key immune regulator against our favorite bug, #Francisella tularensis! #inflammasome link.springer.com/article/10.1...

Rhinovirus triggers distinct host responses through differential engagement of epithelial innate immune signaling Rhinoviruses are the most frequent cause of common colds and also a major cause of respiratory distress in high-risk groups. Using single-cell sequencing of rhinovirus-infected nasal epithelial organo...

Rhinoviruses cause common cold & asthma attacks but are also often benign. Using nasal organoids, we learned how the community of cells in the lining the nasal passages coordinates to respond to rhinovirus and which responses lead to excess mucus & inflammation. www.cell.com/cell-press-b...

LLOMe has long been used to study lysosomal damage, yet how it works has remained a mystery.
Using cryo-electron tomography, we show it forms amyloid structures inside lysosomes that mechanically rupture membranes – revealing a new paradigm for lysosomal failure.

🔗 doi.org/10.64898/202...

#CryoET

Proficiency in French required.
Contact thomas.henry@inserm.fr for research
Jean-Pierre Moussus for teaching.

And coming soon: two additional Associate Professor (MCU) positions at CIRI: 1 in clinical bacteriology (IUT Génie Biologique) & 1 in immunology (Université Claude Bernard Lyon 1).

📢 Recruitment of an Associate Professor (Maître de conférences) in Bacteriology at CIRI and ENS de Lyon.
Research at @ciri-lyon.bsky.social @francoisrousset.bsky.social
@labxc.bsky.social
Anti-phage Immunity, Horizontal gene/ MGE transfer
📚 Teaching at ENS de Lyon within the Department of Biology.

I'm humbled to receive the Paoletti Prize awarded by @cnrsbiologie.bsky.social 😌 and very grateful to present and past mentors !

"Don’t mourn his loss—be grateful that you knew him". Bacteriologist at Pasteur then at INEM, Alain Charbit spent most of his career working on Intracellular bacteria and notably Francisella tularensis to decipher the role of its metabolism in virulence. He was a colleague and a friend.

🌟 New preprint alert! 🌟 We’re excited to share the latest work from @francoisleulier.bsky.social lab, now on bioRxiv!

An ERC Consolidator Grant for Lucie ETIENNE @lucievirevolte.bsky.social, Researcher PI at the CIRI (@cnrs-rhoneauvergne.bsky.social, @ensdelyon.bsky.social, @insermaura.bsky.social, UCBL, @hospicescivilslyon.bsky.social , UJM-Saint Etienne)!
CONGRATULATIONS!!🎉👏

www.insb.cnrs.fr/fr/personne/...

BoltzGen Zoom presentation + Q&A · Zoom · Luma Join us on Zoom on Wednesday, Dec. 17th for details on our new model BoltzGen and discussions on the future of biomolecular design 🧬 There will be a 35 minute…

Join our online BoltzGen presentation and Q&A on Wed. Dec. 17th at noon ET!

A few new results, many new insights, and lots of good discussion, I am sure!

Paper: www.biorxiv.org/content/10.1...
Presentation sign up + Zoom: luma.com/b24bd37m

Kudos to Pauline, Flora, Yvan and the #Pyrin team, and many thanks to all the collaborators notably @sophiegeorgin.bsky.social @fhu-inflamme.bsky.social, Alessandra Carbone & Marco Gattorno's teams.

Finally, thanks to Guilaine Boursier, Martin Broly and Florian Milhavet, we used SpeckSeq and the international variant classification guidelines to update the Infevers website and disseminate the revised classification. infevers.umai-montpellier.fr/web/search.p...

SpeckSeq was validated in primary cells from patients with specific MEFV genotypes and led to new diagnoses. Particularly, we describe two patients homozygous for a rare pathogenic MEFV variant and presenting with an atypical phenotype: generalized pustular psoriasis with systemic inflammation.

SpeckSeq is a mutation scanning experiment guided by human genetics. It highlights key residues along the pyrin protein including around the phosphorylated serine residues, in the B-box domain and in the B30.2 domain, a protein pocket where pregnanolone, a progesterone catabolite docks.

SpeckSeq separates the MEFV variants depending on their hyper-responsiveness to distinct stimuli classifying them as either FMF-like variants or PAAND-like variants.

Discover SpeckSeq, a method combining DNA barcoding of gene variants, single cell sorting based on ASC speck formation and NGS. 228 MEFV variants classified in a single experiment. Novel pathogenic variants identified in addition to the well known FMF and PAAND variants.

Here is the latest paper of the lab @ciri-lyon.bsky.social on the pyrin #inflammasome, the MEFV gene variants and the associated autoinflammatory diseases, Familial Mediteranean fever (FMF) and PAAND.

International Call: recruitment of an Early-Career Team Leader in Virology at CIRI!
For further information: ciri.ens-lyon.fr/nous-rejoind...

The NLRP6 inflammasome is activated by sterile or pathogen-induced endolysosomal damage | The EMBO Journal imageimageThe innate immune sensor NLRP6 is known to control host defense against bacteria and viruses in the gastrointestinal tract by a poorly-understood mechanism. This study shows that NLRP6 forms...

Our latest work from @brozlab.bsky.social and led by @alexandraboegli.bsky.social is out now in @embojournal.org. Check out our findings on how the intestinal #inflammasome NLRP6 senses lysosomal damage to trigger pyroptotic cell death.

So excited that this study is now online! It's been a pleasure to work with BioAge Labs and our collaborators on this story. We characterise a new class of #NLRP3 inhibitors with translational potential for so many inflammatory diseases.

Paper(s) alert from our RESOLUTE project – In a compilation of four papers in @molsystbiol.org we show how we were deciphering cellular logistics and present a comprehensive systematic blueprint of chemical transport pathways with #SoluteCarrier transporters

Endolysosomal damage surveillance enables rapid inflammasome sensing of pathogens Shivcharan et al. report that endosomal damage sensing by the danger receptor galectin-8 licenses noncanonical inflammasome activation and pyroptosis during intracellular bacterial infections in human...

We are excited to have our new paper out: Tethering of the pathogen sensor caspase-4 to the endomembrane damage sensor galectin-8 poises the host to rapidly detect pathogens that breach the endolysosomal network.
www.cell.com/cell-reports... #innate_immunity #inflammasome #celldeath #immunoSky 1/2

Centromeric DNA amplification triggered by viral proteins activates nuclear cGAS Herpesvirus proteins disrupt centromeres, triggering centromeric DNA amplification and local nuclear activation of the nucleic acid sensor cGAS. This reveals an immune surveillance mechanism in the nu...

#LocationLocationLocation! #NewVirusSensingModality! Lahaye, @manellab.bsky.social &co show @cp-cell.bsky.social that nuclear cGAS senses viruses by recognizing centromeric DNA amplification caused by viral effectors that degrade centromere proteins! www.cell.com/cell/abstrac...

Review: Spaan, Boisson, and @sethlucianmasters.bsky.social review the known primary disorders of the polyubiquitination pathways in humans that lead to #autoinflammation and/or #immunodeficiency rupress.org/jem/article/...

🔥 Open postdoc position in human inflammation-driven control of infection! 🔥
Join me at the University of Geneva, Switzerland this summer as I’m moving my Wellcome-funded research activity to the Department of Microbiology and Molecular Medicine! (1/5)

Please share!