Out now! The latest paper from the lab, spearheaded by Philipp Schenk, describing a new USP9X inhibitor with a unique DUB binding site.

www.biorxiv.org/content/10.6...

Proud to share the yeast telomerase structure, led by the talented @hongmiaohu.bsky.social in collaboration with the Wellinger and Chartrand labs. Discovered 37 years ago and took us nearly 7 years but totally worth the wait 😍.
www.science.org/doi/10.1126/...
www.youtube.com/watch?v=gFE4...

We are thrilled to share our latest work uncovering the mechanistic basis of target-directed microRNA degradation (TDMD). This work was driven by @jakobfarnung.bsky.social and @elenaslo.bsky.social in a fantastic collaboration with Brenda Schulman's lab. tinyurl.com/E3TDMD (1/5)

Postdocs Nirbhik Acharya and @jessniblo.bsky.social worked awesomely together to show how disordered regions regulate folded domain interactions that affect UBQLN structure, dynamics, and binding. Illustrating the power of experimental (NMR, SAXS) and computational collabs on full-length proteins!!!

Very happy to share our recent preprint describing #Golgi protein quality control #PQC in mammalian cells. #proteasome #ubiquitin #ChemBio Fantastic work by @joaodiamantino.bsky.social and team! #proudPI @unidue-zmb.bsky.social @imprs-lm.bsky.social

New Review in Trends in Cell Biology with @lumirare.com.
First integrative catalogue of 267 cullin-RING substrate receptors (93 linked to germline disorders) + programmatic-friendly Excel resource for the community.

www.cell.com/trends/cell-...

Excited to announce that FASEB Ignite Career Forum 2026 (preceding FASEB Ubiquitin Mechanisms, Functions, and Therapeutics & Protein Folding in the Cell) is open for registration! Abstract deadline - April 6, 2026
For more details -
events.faseb.org/event/Protei...
events.faseb.org/event/Ubiqui...

Automatic screening of cryo-EM grids using EPU is fast and efficient, but reviewing the generated data & picking the best areas for data collection can be slow and cumbersome. We made a little tool that makes this process more streamlined and enjoyable: github.com/mvorlander/E... 1/4

How does the cell tune p97/Cdc48 activity for different substrates?
Study suggests different adaptor combinations function as molecular accelerators of protein clearance.

www.science.org/doi/10.1126/...

Structural remodeling of the mitochondrial protein biogenesis machinery under proteostatic stress Cryo–electron tomography reveals how mitochondria reorganize their translation and folding systems under proteostatic stress.

Structural remodeling of the mitochondrial protein biogenesis machinery under proteostatic stress

www.science.org/doi/10.1126/...

M1-linked ubiquitination by LUBAC regulates AMPK signalling and the response to energetic stress - Cell Death & Differentiation Cell Death & Differentiation - M1-linked ubiquitination by LUBAC regulates AMPK signalling and the response to energetic stress

More evidence that LUBAC has functions beyond inflammation: Our study shows that LUBAC regulates AMPK signalling to control metabolic adaptation, autophagy, and cell death. This might explain the metabolic problems observed in LUBAC deficiency and ORAS patients. www.nature.com/articles/s41...

Degrons and degradation signals beyond short linear motifs - Nature Chemical Biology Degrons are degradation signals in target proteins to direct recognition and degradation by the ubiquitin–proteasome system. Wang et al. introduce degrons of different types, with an emphasis on high-...

www.nature.com/articles/s41...

FAF1 and FAF2 enhance human p97-UFD1-NPL4 complex unfoldase activity enabling rational design of p97 activators www.biorxiv.org/content/10.64898/2026.02...

This project started with confusion 🤔 www.nature.com/articles/s41...

Loss of LUBAC or OTULIN causes severe inflammatory disease. But patients also show clear metabolic defects.

Neither LUBAC nor OTULIN had been linked to metabolic regulation.

So where do these metabolic manifestations come from?

🧐 What if metabolic defects are not just a consequence of inflammatory disease - but actively contribute to it?

Inflammation and metabolism are deeply intertwined, but the molecular links remain unclear.

Our new paper in Cell Death & Differentiation uncovers one. 🧵👇
nature.com/articles/s41...

This is a video summarizing our recent paper (www.nature.com/articles/s41...)

youtu.be/eNY2CRlYTRo

FEBS Press Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the n....

Our new review on proteostasis of organelles in aging & disease is now online in The FEBS Journal!
We discuss recent insights on how #proteostasis safeguards organelle integrity and function across the cell in #aging and disease
doi.org/10.1111/febs...

David's AlphaFold WorkShop 2026 YouTube video by David Fay

Greetings! I decided to make a YouTube video of my AlphaFold workshop that I've given a few times in the past year. Caveats aside, people seem to find this useful for thinking about how to model protein interactions and how to interpret various AF outputs 1/2

www.youtube.com/watch?v=u63o...

MoSAIC: An Integrated and Modular Workflow for Confident Analysis of Protein Post-Translational Modification Landscapes Investigating multiple protein post-translational modifications (PTMs) is critical for unraveling the complexities of protein regulation and the dynamic interplay among PTMs, a growing focus in proteo...

MoSAIC: An Integrated and Modular Workflow for Confident Analysis of Protein Post-Translational Modification Landscapes #MCP www.mcponline.org/article/S153...

We are thrilled to share our new pre-print on the molecular anatomy of nuclear proteasome in human sperm cells! #In-cellcryo-ET + #SPA + #LM! @piotrkolata.bsky.social @a-dsantos.bsky.social, @tomdendooven.bsky.social!! doi.org/10.64898/202...

UBA6 specificity for ubiquitin E2 conjugating enzymes reveals a priority mechanism of BIRC6 Nature Structural & Molecular Biology - Riechmann et al. uncover structural features governing ubiquitin transfer from ubiquitin-activating E1 enzymes UBA1 and UBA6 to specific E2...

Excited to share our work into ubiquitin E1-E2 specificity mechanisms. CryoEM visualising #ubiquitin transfer,biochemistry,evolution @labhofmann.bsky.social & tissue expression analyses @psarkies.bsky.social Big thanks to the team,reviewers & handling editor @dimitristypas.bsky.social rdcu.be/eTRdR

Induced ubiquitination of the partially disordered Estrogen Receptor alpha protein via a 14-3-3-directed molecular glue-based PROTAC design Proteins lacking defined ligandable pockets remain challenging drug targets. Here, we develop a molecular glue-based PROTAC (MGPROTACs) approach that chemically conjugates a molecular glue stabilizer ...

Induced ubiquitination of the partially disordered Estrogen Receptor alpha protein via a 14-3-3-directed molecular glue-based PROTAC design

Cytoplasmic ribosomes on mitochondria alter the local membrane environment for protein import. rupress.org/jcb/article/...

Induced ubiquitination bypasses canonical ERAD to drive ER protein degradation Heterobifunctional proteolysis-targeting chimeras (PROTACs) have emerged as a powerful strategy to degrade disease-relevant proteins, enabling targeting of previously "undruggable" proteins. Current d...

New preprint out! We show that PROTAC-induced ubiquitination can bypass canonical ERAD to degrade ER membrane proteins. Wonderful collaboration w/ @dannomura.bsky.social and huge credit to grad student superstar Sydney Tomlinson!
www.biorxiv.org/content/10.1...

We’ve made some new tools to manipulate N-recognins. Check them out in our preprint.
www.biorxiv.org/content/10.1...

ZAK activation at the collided ribosome - Nature The kinase ZAK is activated at collided ribosomes to mediate the ribotoxic stress response.

Check out our latest work on how collided ribosomes activate the MAP3K ZAK! 💫

www.nature.com/articles/s41...

A fun collaboration with @beckmannlab.bsky.social @doubleshuang.bsky.social

Degrons and degradation signals beyond short linear motifs - Nature Chemical Biology Degrons are degradation signals in target proteins to direct recognition and degradation by the ubiquitin–proteasome system. Wang et al. introduce degrons of different types, with an emphasis on high-...

A new Review discusses how degrons of different types, with an emphasis on high-order structural ones, regulate substrate-E3 interactions and how their dysregulation is linked to human diseases

www.nature.com/articles/s41...

MISO: microfluidic protein isolation enables single-particle cryo-EM structure determination from a single cell colony.

Or from a single dish of HEK cell culture in the case of two membrane proteins.

Out in Nature Methods now! lnkd.in/gpyBSceg

Wonderful collaboration with the Efremov lab.

Leucine inhibits degradation of outer mitochondrial membrane proteins to adapt mitochondrial respiration - Nature Cell Biology Li et al. uncover a connection between metabolic cues and mitochondrial protein degradation, showing that specifically leucine stabilizes outer mitochondrial membrane proteins by inhibiting ubiquityla...

Very interesting work by Hoppe group. Leucine inhibits degradation of outer mitochondrial membrane proteins to adapt mitochondrial respiration | Nature Cell Biology share.google/0GpbVUCmqJ8Q...