This is figure 1, which shows immune cellular dynamics through the lifespan differ between male and female donors.

An analysis in Nature Aging identifies sex-specific changes in inflammation, autoimmunity and disease risk over the adult lifespan, with more widespread age-related immune remodeling in females. go.nature.com/4mwYVyJ #medsky 🧪

New paper out from the Weller Lab! Streptococcus mutans membrane vesicles carry abundant small RNAs, including tRNA and rRNA fragments, & profile is pH dependent. pH changes what S. mutans export to neighboring microbes & host tissues. #oralmicrobiome #saliva

onlinelibrary.wiley.com/share/7GCHMB...

Hormonal transitions across the lifespan shape susceptibility to Sjogren’s disease AbstractObjectives. Sjogren’s disease (SjD) shows a strong female predominance, but the contribution of age-related hormone changes to this sex bias remain

#Sjogrens disease sex bias changes w/ age. In >100k SjD cases & 1.33M controls, male prevalence peaks in early childhood (30.1%), drops in adults (9.8%), then rises in older adults (13.5%). The pattern tracks population testosterone and estradiol trajectories. #SjD

academic.oup.com/rheumatology...

Infographic titled “New Hepatitis D Antibody Retesting by NHANES.” Two columns compare original vs retested anti-HDV results in HBV marker positive samples, 2007–2020. Original testing used the Diasorin ETI-AB-DELTAK-2 immunoassay and shows 23% anti-HDV positivity, 55 positives total. Retesting used the International Immunodiagnostics HDV Ab (IID HDV Ab) ELISA and shows less than 1% positivity, 2 positives total. The center panel highlights the large drop after retesting and asks whether retesting may underestimate true HDV prevalence.

Drastic shift in NHANES anti-HDV results after retesting (2007–2020). Original testing found 55 anti-HDV positive samples among HBV marker positive samples tested. Retesting found only 2. Is this fixing false positives, or missing true low-level anti-HDV signal? #NHANES #HDV #HBV #Hepatitis

A replication-competent deltavirus from the marsupial fat-tailed dunnart Sminthopsis crassicaudata Deltaviruses are circular, negative-sense RNA agents that replicate autonomously but depend on heterologous envelope glycoproteins for spread. Only partial sequences of deltaviruses had been reported ...

Zoe Denis a PhD student in our lab , describing the first marsupial deltavirus ! :)

HDV doesn’t require HBV for replication. Only packaging and transmission. HDV uses host cellular proteins for replication. It’s just hitching a ride. Also been shown to package into other non-HBV particles (HCV, dengue, VSV).

Cost-Effectiveness of One-time Universal Testing for Hepatitis D among Adults living with Chronic Hepatitis B in the United States AbstractBackground. Chronic hepatitis D virus (HDV) infection increases the risk of liver-related deaths in adults with chronic hepatitis B (CHB). In the U

In CID, Mehlika Toy and colleagues aim to calculate the cost-effectiveness of one-time universal hepatitis D virus (HDV) testing of hepatitis B surface antigen (HBsAg)-positive adults living in the US. academic.oup.com/cid/advance-...

Sjögren’s Disease Investigational Trial | See If You May Qualify Answer questions about qualifying for this Sjögren’s disease investigational trial.

New #Sjogrens Study Recruiting (just sharing info): sjogrensdiseaseresearch.com/prescreener....

Bowling!!!

Today in #SjDResearch: Interesting review paper on hearing loss in #Sjogrens and other autoimmune diseases. Limited studies have looked at this link. Prevalence in larger cohorts? Mechanisms? Paper: Hearing Loss in Connective Tissue Diseases: A Systematic Review www.eurjrheumatol.org/en/hearing-l...

Anyone seeing reports of patients with #HepatitisD in the absence of #HepatitisB? My team is detecting #HDV antigens and RNA in salivary glands of #Sjogrens patients without evidence of #HBV. Thinking its more widespread. Current testing guidelines would miss. #ViroSky #LiverSky #GastroSky

There are multiple reports of #HDV being detected in the absence of #HBV. My lab detected HDV protein and rna in salivary glands of patients with #Sjogrens disease (~50% of pts). No evidence of past HBV infection. Expression of HDAg causes disease. Multiple small reports of HDV+ blood w/out HBV.

Insights into the Correlation and Immune Crosstalk Between COVID-19 and Sjögren's Syndrome Keratoconjunctivitis Sicca via Weighted Gene Coexpression Network Analysis and Machine Learning - PubMed <span><b>Background:</b> Although autoimmune complications of COVID-19 have aroused concerns, there is no consensus on its ocular complications. Sjögren's syndrome is an autoimmune disease accompanied...

Today in #SjDResearch: More links between infectious diseases and #Sjogrens. Paper detailing molecular overlap between #COVID19 & #SjD related dry eye using WGCNA + machine learning. 🧬 Shared immune pathways + 10 hub genes point to common mechanisms of inflammation. pubmed.ncbi.nlm.nih.gov/40149556/

Detection of hepatitis delta virus RNA in cervical swab and seminal plasma of chronic hepatitis delta patients - PubMed HDV-RNA can be detected in cervical swabs and seminal plasma of patients with HBV/HDV coinfection, and the detection was more common in females than in males. The probability of HDV-RNA detection in m...

Today in #HDVResearch News: Detection of hepatitis delta virus RNA in cervical swab and seminal plasma of chronic hepatitis delta patients. Study in Mongolia, 60 patients, HDV RNA detected in 80% of cervical swabs & 50% of seminal plasma samples. #HDV #HepD #HBV pubmed.ncbi.nlm.nih.gov/40147883/

There is a #Sjogrens feed on Bluesky. Look for it and if you have any issues let me know.

New #Feed: #Sjogrens #Sjogren's #Sjögren's #SjD #SjS #pSS #SjogrensDisease #SjogrensSyndrome #SjogrensFoundation

Exploring the latest research on #Sjogrens and emerging treatments, patient experiences, advocacy updates, and insights to improve understanding and care.

bsky.app/profile/did:...

New #Feed: #HDV #HepD #HepatitisD #HepatitisDVirus #HDV-like #Kolmioviridae #HepDVirus Tracking the latest in HDV and HDV-like viruses, from new publications to scientific breakthroughs and global events. Exploring virology, epidemiology, treatments, and diagnostics.

bsky.app/profile/did:...

#HepD

I just built a #Sjogrens feed if you wanted to follow. It should list all the posts with #Sjogrens from now on. It looks like the Sjogrens community on bluesky is growing. 😀 bsky.app/profile/did:...

I saw your post about needing a #Sjogrens feed. I built one. All posts that contain #Sjogrens and variants of are included. If it needs to be modified/improved, just let me know. To find: use link below or go into #Feeds on left bar, Discover New Feeds, then search Sjogrens. bsky.app/profile/did:...

#sjogrens

Age-dependent sex disparities in Sjogren's disease prevalence align with natural hormone fluctuations Sjogren′s Disease (SjD), like many autoimmune diseases, shows a strong female–to–male sex bias, raising the possibility of a hormone-mediated mechanism. However, specific hormonal drivers and the unde...

Sex bias in #Sjogrens isn't static—fluctuates with age & hormones! 100K+ patient study reveals:
🟢More males in childhood (30%)
📉Decline in adult males (10%)
📈Rise again in older men as testosterone drops!
Testosterone may be protective!
MedRxiv Preprint: www.medrxiv.org/content/10.1...
#SjD #SexBias

RFK Jr welcoming ceremony live stream link Feb 18th 10am est.

www.hhs.gov/live/office-...

Editing scientific content for political purity is turning MMWR into a compromised propaganda organ.

And why are the propaganda squads at CDC replacing specifically H5N1 bird flu studies?

I’ve got some pretty serious fascism- and flu-related concerns about this.