Targeted toothpaste inhibits gum disease bacteria while preserving the oral microbiome Researchers in Germany have developed a new approach to preventing gum disease that avoids disrupting the mouth’s natural bacterial balance. Instead of relying on traditional antiseptic ingredients that kill both harmful and beneficial microbes, the new method focuses on selectively inhibiting only the bacteria responsible for periodontitis. The work, led by scientists at the Fraunhofer Institute for Cell Therapy and Immunology (IZI), identified a compound called guanidinoethylbenzylamino imidazopyridine acetate. Rather than killing bacteria outright, this substance prevents the growth and activity of key pathogens such as Porphyromonas gingivalis, which are strongly associated with gum inflammation and periodontal disease. By stopping these harmful microbes from multiplying, the compound allows beneficial oral bacteria to remain in place and recolonize areas that would otherwise be dominated by disease-causing organisms. This helps maintain or restore a healthy oral microbiome and reduces the risk of dysbiosis, a microbial imbalance linked to recurring gum disease. Conventional products like alcohol-based mouthwashes and chlorhexidine can eliminate a broad range of bacteria, but they also disrupt the natural ecosystem, often allowing harmful species to rebound quickly after treatment. The technology has been developed further through collaboration with the spin-off company PerioTrap Pharmaceuticals, resulting in a toothpaste designed to support long-term gum health. The formulation also includes standard ingredients such as fluoride and abrasives for cavity prevention. Additional products, including a post-cleaning gel and potential future mouthwash, are being explored. Researchers emphasize that extensive safety and compatibility testing was required to ensure the compound is non-toxic and suitable for everyday use. All development followed strict laboratory standards, aiming to create a medical-grade oral care solution that preserves microbial balance rather than eliminating it.

Targeted toothpaste inhibits gum disease bacteria while preserving the oral microbiome

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#gumdisease #oralmicrobiome #toothpaste

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🔬#GMC2026 Call for Papers
📢Abstract deadline: April 22
microbiomecongress.org/abstract-sub...

🥗Diet shapes the oral microbiome promoting balance eubiosis or disease dysbiosis. From polyphenols to probiotics, nutrition impacts oral & systemic health.

#OralMicrobiome #Microbiome #Nutrition

Logo of Microbiology Society with abstract white line design on dark blue background accented by colorful dots and shapes.

Join us at 1pm today for this month’s Safe Microbiome Perturbations webinar on 'Oral Microbiome and Bioinformatics Approaches.' Register for free: https://microb.io/4cx4avi
#OralMicrobiome #WebinarSeries

Virtual webinar on oral microbiome and bioinformatics scheduled for March 20, 2026, featuring experts Nick Jakubovics and Robert Finn.

Register for our limited online seminar series, Safe Microbiome Perturbations.
Join us next Friday at 1pm (GMT) for an insightful session on 'Oral Microbiome and Bioinformatics Approaches.' Register for free: https://microb.io/4cx4avi
#OralMicrobiome #WebinarSeries

Register for our limited online seminar series, Safe Microbiome Perturbations.
Join us next Friday at 1pm (GMT) for an insightful session on 'Oral Microbiome and Bioinformatics Approaches.' Register for free: https://microb.io/4cx4avi
#OralMicrobiome #WebinarSeries

Environmental Stress Induces Altered Composition of Streptococcus mutans Membrane Vesicles: pH‐Driven Changes in Membrane Vesicle Production and Composition You have to enable JavaScript in your browser's settings in order to use the eReader.

New paper out from the Weller Lab! Streptococcus mutans membrane vesicles carry abundant small RNAs, including tRNA and rRNA fragments, & profile is pH dependent. pH changes what S. mutans export to neighboring microbes & host tissues. #oralmicrobiome #saliva

onlinelibrary.wiley.com/share/7GCHMB...

📢 Join global experts at the

2nd Edition: GMC 2026

🗓 June 15–16, 2026
📍 Boston, Massachusetts, USA | Hybrid Event

📝 Call for Papers Now Open
⏳ 2nd Round Abstract Submission Deadline: February 22,
2026

🔗 Submit here: microbiomecongress.org/abstract-sub...
#GMC2026 #OralMicrobiome #CallForPapers

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This study has IRB approval.

In #Microbiome

🚨Microbiome stability impairs oral health in children living with HIV

🔍Sampling individual teeth from a cohort of 565 Nigerian children with varying levels of tooth decay severity

Read more 👉 doi.org/psbb

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Is the oral microbiome the secret to a longer life? The oral microbiome is the second largest microbial community in the body – it’s time to take it seriously, experts say

In part. Not completely, but yes it definitely matters.

#OralMicrobiome #GutHealth #Nutrition #Diet #Microbiome #EatWellLiveWell #HolisticHealth #SelfCare 💕 #Wellness

N-acyl homoserine lactone signaling modulates bacterial community associated with human dental plaque npj Biofilms and Microbiomes - N-acyl homoserine lactone signaling modulates bacterial community associated with human dental plaque

New paper out! Big thanks to Mikael Elias’ group at the University of Minnesota—together, we studied how quorum sensing affects dental plaque.

#biofilms #oralmicrobiome

rdcu.be/eQllg

Multiple sclerosis patients exhibit oral dysbiosis with decreased early colonizers and lower hypotaurine level - npj Biofilms and Microbiomes npj Biofilms and Microbiomes - Multiple sclerosis patients exhibit oral dysbiosis with decreased early colonizers and lower hypotaurine level

Multiple sclerosis patients exhibit oral dysbiosis with decreased early colonizers and lower hypotaurine level
#microbiology
#OralMicrobiome
www.nature.com/articles/s41...

The Mouth-Body Connection: Hacking Your Health Starts in Your Mouth What if the single biggest threat to your brain and heart health isn't your diet or your genes... but the silent war being waged in your gums right now? It's time to talk about the most overlooked secret to overall health. Welcome to a mind-blowing exploration of the Mouth-Body Connection, where we reveal how your dental health is the gatekeeper to your entire body's well-being. This isn't just about cavities; we're diving deep into the science of the Oral Microbiome, the complex ecosystem of bacteria in your mouth that holds the key to preventing chronic disease. You'll learn how an imbalance, known as oral dysbiosis, and common gum disease like periodontitis can unleash a wave of inflammation throughout your system. We unpack the groundbreaking research from institutions like UCSF that links key oral pathogens, like the superbug Porphyromonas gingivalis, to a shocking list of conditions: Alzheimer's disease, cardiovascular disease (CVD), diabetes, and even rheumatoid arthritis. This is the ultimate guide to understanding how a problem in your mouth can become a crisis for your body. But it's not all doom and gloom. We'll also explore the cutting-edge preventative strategies and treatments, from targeted probiotics to advanced dental care, that can rebalance your oral microbiome and protect your systemic health for years to come. Ready to take control of your health from the inside out? Subscribe now and discover how protecting your mouth is the single best thing you can do to protect your brain and body. Your journey to true wellness starts here.

📣 New Podcast! "The Mouth-Body Connection: Hacking Your Health Starts in Your Mouth" on @Spreaker #alzheimers #cardiovasculardisease #dentalhealth #gumdisease #guthealth #healthhacks #healthpodcast #inflammation #mouthbodyconnection #oraldysbiosis #oralhygiene #oralmicrobiome #overallhealth

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Eklund Foundation Announces 2025 Grant Recipients - Eklund Foundation The Eklund Foundation for Odontological Research and Education is pleased to announce the three projects receiving this year’s funding.   The Eklund Foundation supports dentistry related research proj...

Long-term, this could mean more personalized care and help protect baby and mom.

eklundfoundation.org/eklund-found...

#MOMI #maternalhealth #maternalhealthcare #scienceiscool #pregnancyresearch #microbiome #oralmicrobiome #proteomics #somascan #AnthBytes

Congratulations to the 11 trainee travel award recipients during the #OralMicrobiome Conference in #chania #Crete #Greece BRAVO!

Wet Lab Protocols Matter: Choice of DNA Extraction and Library Preparation Protocols Bias Ancient Oral Microbiome Recovery Ancient DNA (aDNA) analysis of archaeological dental calculus has provided a wealth of insights into ancient health, demography and lifestyles. However, the workflow for ancient metagenomics is still...

Outperforms all others—raising important questions about optimization versus standardization.

onlinelibrary.wiley.com/doi/10.1111/...

#ancientDNA #aDNA #oralmicrobiome #microbiome #methods #standards #metagenomics

Ozone exposure weakens lung function and reshapes the oral microbiome Ozone exposure reshapes the oral microbiome and reduces lung function, particularly in men, revealing significant health risks associated with pollution.

🫁 Ozone doesn’t just hurt your lungs — it alters the microbes in your mouth.
⚠️ New study shows even 2 hours of exposure cuts lung function, with men hit hardest.

Read more 👉 🔗 www.news-medical.net/news/2025100...

🌍 #OzoneExposure #LungHealth #OralMicrobiome

Oral Microbes Linked to Higher Pancreatic Cancer Risk

A study of 122,000 adults found 27 oral microbes, including Porphyromonas gingivalis and Candida, linked to threefold pancreatic cancer risk, suggesting a saliva‑based risk score. Read more: getnews.me/oral-microbes-linked-to-... #pancreaticcancer #oralmicrobiome

Oral microbes linked to increased risk of pancreatic cancer – BioNews Central Twenty-seven species of bacteria and fungi among the hundreds that live in people’s mouths have been collectively tied to a 3.5 times greater risk of developing pancreatic cancerd. ...

Twenty-seven species of #bacteria and #fungi among the hundreds that live in people’s mouths have been collectively tied to a 3.5 times greater risk of developing #PancreaticCancer.
#OralMicrobiome #PancreaticCancerRisk

Healthier diets and diverse oral microbiomes lower frailty risk This study links diet and oral microbiome diversity to frailty risk, emphasizing their potential in strategies for healthier aging and improved health outcomes.

Healthy diets + diverse oral microbiomes may lower frailty risk 🥦🦠
New research finds that what you eat and the microbes in your mouth work together to influence healthy aging.

Read more 🔗 www.news-medical.net/news/2025091...

#HealthyAging #OralMicrobiome #DietQuality #NutritionScience

Beet Juice Lowers Blood Pressure in Older People by Changing Their Oral Microbiome The blood pressure lowering effect of nitrate-rich beetroot juice in older people may be due to specific changes in their oral microbiome, according to the largest study of its kind. Researchers at the University of Exeter in England conducted the study which was published in the journal Free Radical Biology and Medicine. It followed previous […] The post Beet Juice Lowers Blood Pressure in Older People by Changing Their Oral Microbiome appeared first on Good News Network.

Beet Juice Lowers Blood Pressure in Older People by Changing Their Oral Microbiome: The blood pressure lowering effect of nitrate-rich beetroot juice in older people may be due to specific changes in their oral… @goodnewsnetwork.org #BeetJuice #BloodPressure #HealthBenefits #OralMicrobiome #Nitrate