Latest pre-print from our lab. We report 6 new #cryoEM structures here:
www.biorxiv.org/content/10.6...

Jason is killing it! 😍

Latest from Steve Harrison

Congrats! 👏🏼

NY state friends, please do this today!

The Governor’s State of the State is tomorrow, January 13 at 1:00 PM. We are hopeful she will announce the Empire Biomedical Research Institute (EBRI).

Email the Governor and your Reps!
actionnetwork.org/letters/supp...

The NIH has lost its scientific integrity. So we left “We can no longer lend our credibility to an organization that has lost its integrity,” write four scientists and administrators who recently resigned from the NIH.

www.statnews.com/2026/01/10/n...

NY medical schools press Gov. Hochul to put up billions for scientific research The request comes amid continuing uncertainty over federal funding, with research and thousands of jobs on the line.

We’re calling on @governor.ny.gov to invest in the Empire Biomedical Research Institute. A robust, stable research ecosystem protects jobs, fuels innovation, and builds community health statewide. NY must invest in our global leadership in science.
@gothamist.com reports:
tinyurl.com/5fab5k7u

The Bajic lab annual holiday outing! This year, we went to the Kiehl’s flagship store, learned about good skincare practices and walked out with some goodies. #HappyHolidays

US senators push USDA for urgent action on bird flu vaccine A bipartisan group of U.S. senators this week urged the administration of President Donald Trump to finalize a science-based plan for developing a bird flu vaccine for livestock, according to a letter...

"The Trump administration in May canceled a $700 million contract with Moderna to develop a human bird flu vaccine. Secretary Kennedy has cut other funding for vaccine research and scrapped long-held federal vaccine guidance."
www.reuters.com/business/hea...

Ionic style columns, I’ll allow it.

The U.S. Is Funding Fewer Grants in Every Area of Science and Medicine (Gift Article) A quiet policy change means the government is making fewer bets on long-term science.

New York Times article on science funding with some depressing but familiar curves with interactive graphics.

www.nytimes.com/interactive/...

Germinal center–mediated broadening of B cell responses to SARS-CoV-2 booster immunization SARS-CoV-2 variant booster vaccination broadens human B cell responses through the germinal center reaction.

SBGrid's eLife paper received a citation in October from@gogo-science.bsky.social from Icahn School of Medicine at Mount Sinai in @science.org Immunology.

Read more here: buff.ly/s8uVL86

#SBGrid #ScienceMatters #StayConnected

How to develop good research questions

"This Comment describes the iterative creative process for designing good research questions, and includes practical suggestions and ways to avoid common traps."

www.nature.com/articles/s41...

**Job Alert** Exciting postdoc position available: theoretical and experimental cryo-EM studies of flexible biomolecules. Competitive salary, collaborative environment at NYSBC and Flatiron Institute. Please share!! and contact: pcossio@flatironinstitute.org

Germinal center–mediated broadening of B cell responses to SARS-CoV-2 booster immunization SARS-CoV-2 variant booster vaccination broadens human B cell responses through the germinal center reaction.

Read the latest from us here:

www.science.org/doi/10.1126/...

#antibody #cryoEM

Amazing! Congratulations! 👏🏻👏🏻👏🏻

I did not expect Treg!

My guess is Mojsov et al. 🤗

Phosphorylation on tyrosines control key pathways in immunity, cancer, and metabolism. For the first time, we can now design proteins that specifically recognize individual phosphotyrosines, even in disordered regions. (1/8)

Preprint: www.biorxiv.org/content/10.1...

Congrats!

The Origin and Diversification of Mitochondria Moving beyond the simplistic view of mitochondria as the power house of the cell, Roger et al. present the immense diversity of mitochondria and mitochondrial functions across eukaryotes, and bring th...

Feeling mitochondrially challenged lately?

Here are two classic reviews on #mitochondria that should help.

www.cell.com/current-biol...

www.cell.com/current-biol...

Heads up: @science.org is looking for a new research #editor based in the US or UK to handle papers in #InfectiousDiseases (e.g., #virology, #microbiology, #parasitology) & #microbiome research! This is an amazing opportunity, so don't delay! Applications are due 22 SEP!

Congrats!

New paper from the Coelho lab with a modest contribution from us:

@cryoempapers.bsky.social

Clonotype-enriched somatic hypermutations drive affinity maturation of a public human antibody targeting an occluded sarbecovirus epitope Rao et al. demonstrate that convergent somatic hypermutations in the light chain, enriched within a sarbecovirus-specific public antibody clonotype, drive affinity maturation. This antibody targets a ...

🚨 New Publication!!!

I’m thrilled to share our latest study, “Clonotype-Enriched Somatic Hypermutations Drive Affinity Maturation of a Public Human Antibody Targeting an Occluded Sarbecovirus Epitope”.
www.cell.com/cell-reports... [1/4]

Clonotype-enriched somatic hypermutations drive affinity maturation of a public human antibody targeting an occluded sarbecovirus epitope Rao et al. demonstrate that convergent somatic hypermutations in the light chain, enriched within a sarbecovirus-specific public antibody clonotype, drive affinity maturation. This antibody targets a ...

The latest from us:
www.cell.com/cell-reports...
With Camila Coelho’s lab, we describe how public clonotype #antibody affinity matures against an occluded epitope on #spike we call the central interface epitope! #cryoEM

Mix-it-up: Accessible time-resolved cryo-EM on the millisecond timescale www.biorxiv.org/content/10.1101/2025.07.22.666177v1 #cryoEM

To celebrate @focisimmunology.bsky.social 's annual meeting this week, #Science #Immunology has just released a new free sample collection of recent papers with a focus on human immunology! The collection will be available online to read until the end of July 2025! #FOCIS2025

bit.ly/SciImm_free

So cool!