The fuzzy coat is increasingly going from a fuzzy mess to a recognized key target. #amyloid

Full-Length Molecular Models of Brain-Derived α-Synuclein Fibrils Reveal a Fuzzy-Coat-Mediated Mechanism for Selective Peptide Binding www.biorxiv.org/content/10.64898/2026.04.16.718707v1 #cryoEM

The Critical Assessment of Structure Prediction (CASP) experiment is calling for prediction targets: Immune Complexes, Organic Ligand-Protein Complexes, Nucleic Acids and Complexes, Conformational Ensembles, Difficult Protein Structures and Complexes. Rule of Thumb: If AlphaFold3 can generate a high-quality model, it is likely not a CASP-grade challenge. If it struggles, we want it.

Is #AI hitting a plateau in structure prediction? Help us find out at CASP17! 🧪🧬

Calling for Targets: Immune Complexes, protein - ligand complexes, RNA/DNA, conformational ensembles, membrane proteins, viral origins, and large complexes.

The Rule of Thumb: If AF3 can’t model it, we want it.

When to submit targets: NOW - July 10, 2026.

How to submit targets:

predictioncenter.org/casp17/callF...

three men in red robes are standing next to each other with the caption nobody expects the spanish inquisition ALT: three men in red robes are standing next to each other with the caption nobody expects the spanish inquisition

“Eerder is wel geopperd om met onaangekondigde bezoeken te gaan werken.”

ukrant.nl/tweede-kamer...

That’s Eric Idle’s point.

Stay positive even when life’s a piece of shit (when you look at it).

Still the most popular song at British funerals.

Betrouwbare Bronnen 580 👉Lenteboekenspecial 📚Nieuwe boeken 📚Over unieke vrouwen, ideologen, ballingen, sublieme schrijvers, politici, denkers en grote liefdes 📚omny.fm/shows/betrouwbare-bronne...

IKEA assembly 🤯

Cover Feature of ChemistryEurope

Thrilled to share that our latest work is featured on the cover of the current issue of @chemistryeurope.bsky.social!
Read the full paper here: doi.org/10.1002/ceur.70264
🧪 #chemsky #MOFs #FlueGasDesulfurization

I thought somehow this was a @inprep.bsky.social post

They got the name from this paper. LMFAO.
ciencias.ulisboa.pt/sites/defaul...

Captain Haddock looking very frazzled, saying, “What a week, huh?” Tintin leans into the frame and says, “Captain, it’s Wednesday.” Snowy aka Milou is very excited about the drink he has found. Viñeta de Tintin El capitán Haddock, sentado a una mesa y con aspecto de estar agotado, dice: "¡Menuda semana, ¿eh?". Tintín, a su derecha, le dice: "Capitán, es miércoles". A la izquierda, Milú mira muy contento la bebida que está en la mesa.

Tomorrow is #GivingDay at @vanderbilt.edu. Your gift to the Dr. Anne Karpay Award in Structural Biology supports a senior graduate student who well-rounded, collaborative, collegial and has performed exceptional research in structural biology.
www.givecampus.com/campaigns/57...

Bluebird posting will continue until morale improves 🪶

Rapid Quantification of Pharmaceuticals via 1H Solid-State NMR Spectroscopy The physicochemical properties of active pharmaceutical ingredients (APIs) can depend on their solid-state forms. Therefore, characterization of API forms is crucial for upholding the performance of p...

… and:

Rapid Quantification of Pharmaceuticals via 1H Solid-State NMR Spectroscopy

doi.org/10.1021/acs....

Enhancing half-integer quadrupolar solid-state NMR signals via steady states: A double frequency sweep-based approach We introduce a novel signal enhancement technique, termed steadyDFS, for quadrupolar solid-state nuclear magnetic resonance spectroscopy. It can substantially i

… with published chapters such as:

Enhancing half-integer quadrupolar solid-state NMR signals via steady states: A double frequency sweep-based approach

doi.org/10.1063/5.02...

Three-year funded postdoctoral fellowship for scientists returning after a 12-month career break, deadline May 17, 2026.

The LMB is proud to launch the Career Returner Fellowship, a three-year, fully funded postdoc placement for scientists who have had a career break of over 1 year.

Applications are open now!

More details: mrclmb.ac.uk/careers-and-...

Please share this post with anyone who may be interested!

Spent today at Radboud University in Nijmegen for the PhD defense of Angel Wong. Great job with lots of cool #ssNMR and a very detailed scientific discussion. Congrats to Dr Wong!

Pittsburgh Post-Gazette announces it has found a buyer to keep the newspaper open Owners of the Pittsburgh Post-Gazette said they have found a buyer who had agreed to keep the newspaper open, less than a month before it was due to shut down.

The nonprofit that runs the successful, Pulitzer-winning Baltimore Banner is going to take over the Pittsburgh Post-Gazette.

Of all the possible outcomes here, this is likely the best we could have hoped for.

apnews.com/article/pitt...

Regarding DISCO: bsky.app/profile/mart...

Great presentation by @francesarnold.bsky.social for the Backer lecture this afternoon! Organized by the Backer Foundation (www.backerfoundation.nl), held at the @rug.nl . About evolving an designing novel enzymes. Very cool! (With quite some machine learning and even some DISCO )

Blue-green glowing larvae that look like strands of beads hang down from a cave ceiling.

Blue-green glowing larvae that look like strands of beads hang down from a cave ceiling.

Behold Arachnocampa luminosa, aka the New Zealand glowworm. The larval forms use their blue-green bioluminescence to lure prey into silk snares (meanwhile, the adults take the form of tiny gnats).

It is saddening to watch foundations of US scientific research fall apart. But Europeans are not going to sit in a corner and bemoan fate. They and the rest of the world have no choice but to develop the capacity needed to compensate for the erosion of American state capacity

a man with a mustache is drinking from a glass while wearing a blue jacket . ALT: a man with a mustache is drinking from a glass while wearing a blue jacket .

The one thing (and only thing!) that is fun about grading exams is that in order to get to the answers in our exam environment I need to select "Quiz master".

#helloglitter

Blocking a toxic fragment: new mouse study highlights the importance of HTT1a in Huntington’s disease – HDBuzz In plain language. Written by scientists.For the global HD community.

New research in an HD mouse model points to a key culprit: HTT1a

Lowering this small fragment delayed disease signs in mice, pointing toward a new direction for next-gen HTT-lowering therapies.

Even in early days, it's a promising step forward.

Full Article: en.hdbuzz.net/blocking-a-t...

... hmmm… like you said, from the reviewer report it is hard to understand why it took so long. Must be largely on side of authors I suppose.

It is a bit odd how in one round three additional reviewers were recruited though. (We had before that over multiple rounds additional reviewers were added)

(And perhaps they first submitted to another Nature journal before being re-routed to Nature Comm? 🤯. )

Hold On Hope: publication lag times at cell biology journals Publication lag times are still a frustration for researchers. Although preprints circumvent the delay in sharing science with others, publication is still king when it comes to evaluation. Contracts are short and publication delays can be long…

It's been a while... dusted off some old code to see what the current publication lag times are at cell bio journals.

At the end of the post there's the poor paper with the longest delay in the dataset...

Hold On Hope: publication lag times at cell biology journals

quantixed.org/2026/04/09/h...

I wonder how many editors were involved. We had a switch in editors in one of our recent papers, which took a mere 23 months to get published (same journal as in the post above). Over so many years I could imagine multiple editor changes