These are both coming from some of #biophysics oriented research groups of the @zernike-institute.bsky.social of the @rug.nl . With special thanks to committee member Henrike Heise who came from Germany for Raffaella’s defense and treated us to a great #ssNMR and DNP talk yesterday

.. it is from a very nice collaboration with the group of Alessandra Operamolla from the University of Pisa. We looked at cellulose nanocrystals with conjugated lipase enzymes, using #ssNMR and other techniques. The #ssNMR was supported by @mosbri.bsky.social transnational access (TNA).

New collaborative paper from the lab: “Candida rugosa Lipase Bioconjugation to Cellulose Nanocrystals with High Immobilization Efficiency: Comparison with Nonspecific Approach” in the @acs.org journal Biomacromolecules. doi.org/10.1021/acs....

Another #glycotime by #ssNMR project…

Reminder: the deadline for this #ssNMR job application closes on 15 Dec!

Postdoc SSNMR - Rijksuniversiteit Groningen

With funding from the Dutch NWO, we are looking for a postdoc with expertise in #DNP and/or #ssNMR experiments/hardware. One focus in the work will be to follow-up on our work on in-situ illuminated ssNMR for studying #photochemistry processes. #nmrchat werkenbij.rug.nl/vacature/pos...

Transforming solid-state nuclear magnetic resonance towards a chemistry-ready technique Solid-state nuclear magnetic resonance (solid-state NMR) is an essential tool for probing local structure and dynamics in complex materials, yet its u…

out now: "Transforming solid-state nuclear magnetic resonance towards a chemistry-ready technique"
#PANACEA #NMR #SSNMR
www.sciencedirect.com/science/arti...

The Dutch NMR Discussion Group - SAC

Today is the day: the 60th Dutch #NMRDG meeting bringing together the magnetic resonance community of the Netherlands. This time hosted at Radboud University in Nijmegen.

See: sac.kncv.nl/nmr

#nmrchat #epr #ssnmr

Huge thanks to the local organizers at Radboud and to our sponsors.

All in all, we hope that the information about the probe/methods can be useful to other #ssNMR groups interested in this topic. Moreover, we expect this approach to be useful for many other applications and studies, with some more of our own work coming…. #nmrchat #photochemistry #optogenetics

In this paper we describe how we used in-situ illumination during #ssNMR to probe photochemical processes. This is enabled by a modified MAS NMR probe from Bruker Biospin @brukercorporation.bsky.social in which a light fiber enables sample irradiation using a LED light source. ….

Photo of the alps in Chamonix

Well, it’s a wrap! The 2025 Alpine meeting on magnetic resonance in solids has concluded today. As usual I really enjoyed it (and learned some interesting new things). Thanks to all speakers from all over the world, as well as the organizers! #ssNMR

Entropy-Driven Disorder and Aliovalent Substitution Induce Defects in Na3PnS4 (Pn = P, As, Sb) Solid-State Electrolytes: A Sluice Gate for Sodium Ions Sodium-containing chalcogenides are attractive candidates for use as solid-state electrolytes; however, their ionic conductivities remain a challenge. Simultaneously applying isovalent and aliovalent ...

Check out Madhu's latest results, including 75As & 121Sb #SSNMR 🧲🧪

Entropy-Driven Disorder and Aliovalent Substitution Induce Defects in Na3PnS4 (Pn = P, As, Sb) Solid-State Electrolytes: A Sluice Gate for Sodium Ions | ACS Materials Letters pubs.acs.org/doi/10.1021/...

Traveling to Chamonix for the Alpine meeting on magnetic resonance in solids today. See you there? #ssnmr

Redirecting

New paper from the Griffin lab: “Diamond rotors for high magic angle spinning frequencies”

How to make and use diamond 0.7 mm rotors for #ssNMR

doi.org/10.1016/j.jm...

.. (We did some #ssNMR analysis of labeled ala-based peptides in the #coacervates. )

Probing photochemically-induced dynamic transitions by magic-angle-spinning NMR combined with in-situ irradiation. Light is often the stimulus of choice for dynamically changing function in materials, from controlling phase transitions and dynamic chemistry to in-situ polymerizations, crosslinking, and 3D printing...

… and Dr Alessia Lasorsa from the group will discuss our latest preprint on #ssNMR in context of #photochemistry (ref. dx.doi.org/10.26434/che... )... See you there?

Probing How Anti‐huntingtin Antibodies Bind the Fibrillar Fuzzy Coat Using Solid‐State NMR Antibodies are widely used to recognize, detect, and target aggregated and misfolded amyloid-forming proteins, including those associated with HD. Studying such interactions on a structural level is ...

… I will be there, to discuss our recent paper on #ssNMR studies of antibodies binding to #polyQ protein fibrils ( #huntingtonsdisease ). (ref. dx.doi.org/10.1002/chem... ) …

Alpine Conference on Magnetic Resonance in Solids

The start of the upcoming Alpine Conference on Magnetic Resonance in Solids (in #Chamonix) is just a month away. Really looking forward to it - a nice variety of interesting science coming up, looking at the program and abstracts! ghttps://alpine-conference.org #ssNMR (and more) …

Probing photochemically-induced dynamic transitions by magic-angle-spinning NMR combined with in-situ irradiation. Light is often the stimulus of choice for dynamically changing function in materials, from controlling phase transitions and dynamic chemistry to in-situ polymerizations, crosslinking, and 3D printing. The high temporal and spatial control over irradiation underpins the function of photovoltaics, smart materials, biological systems, and optogenetics research. Proper understanding of the associated mechanisms requires insights into the dynamic molecular and (photo)chemical transformations. NMR spectroscopy is a powerful tool for investigating such processes, providing unique information at the atomic level, especially if light can be delivered directly during the NMR experiment. While liquid-state NMR is increasingly regularly coupled with in-situ irradiation, it is limited to soluble sample states. Here we report on the application of in-situ illumination to magic angle spinning (MAS) solid-state NMR (ssNMR). An in-situ irradiation setup adapted to a customized MAS probe enabled sample illumination with high efficiency. We describe its technical features and illustrate its capabilities through representative case studies with relevance to different segments of photochemistry and materials science. These include photoresponsive azobenzene derivatives in solution and sequestered in hydrogels, a chemical actinometer in solution and UV-polymerization of vitrimer-like elastomers. We show how different ssNMR polarization transfer techniques can enable the study of dynamic transitions that accompany light-triggered (dis)assembly and cross-linking processes. We report on the efficient use of not only sapphire but also thin-wall zirconia rotors, in an approach compatible with the widely used Bruker-type MAS ssNMR instrumentation. We envision that these methods will enable diverse new research directions on photoresponsive materials and many other types of samples, where liquid state NMR is not applicable due to their viscous or solid nature.

Our latest preprint is now online at @chemrxiv.org : “Probing photochemically-induced dynamic transitions by magic-angle-spinning #NMR combined with in-situ irradiation.” See: doi.org/10.26434/che...

This is part of our effort toward using in situ irradiation in our #ssNMR studies. ..

GitHub - benMRmagnet1/SSNMR-Calculator Contribute to benMRmagnet1/SSNMR-Calculator development by creating an account on GitHub.

Just released the second version of BenMR. It now includes a Python toolkit that co-adds CPMG echoes to generate continuous lineshape spectra from SSNMR data. Compatible with Bruker TopSpin.

I lost access to my old Github. This is my new one:
📎 github.com/benMRmagnet1...

#NMRchat #SSNMR

Probing How Anti‐huntingtin Antibodies Bind the Fibrillar Fuzzy Coat Using Solid‐State NMR Antibodies are widely used to recognize, detect, and target aggregated and misfolded amyloid-forming proteins, including those associated with HD. Studying such interactions on a structural level is ....

.. in #huntingtonsdisease but may also find effective use in studies of other aggregating #amyloid proteins, from #alzheimers to #parkinsons and beyond.

Read it all at the journal: doi.org/10.1002/chem... (where it is part of the “Hot Topic: amyloids” collection.

#nmrchat #polyQ #ssNMR

.. In the paper we speculate that this may impact on the properties of the fibrils, through a variety of mechanisms. This remains to be studied in more detail. For now, we hope that these types of #ssNMR studies may be useful not only for understanding conformation-selective antibodies …

.. Indeed, this is possible (though not entirely easy), and we observe how MW8 antibody binds the fibril surface and modulates the dynamics of different (exposed) parts of the protein fragments. Combining #ssNMR with #TEM we observe how antibodies cluster fibrils together into larger clumps..

.. Despite the importance of understanding and visualizing such antibody-fibril interactions, this remains challenging. We deployed our #ssNMR toolkit to see whether we can shed light on how a well-known huntingtin-binding antibody finds its epitope in the fuzzy coat of huntingtin clumps ..

If you're attending #EUROMAR2025, stop by and talk with Brian @brphan17.bsky.social and see his #SSNMR poster. 🧲🔋🧪.

The team is visiting @nmr900.bsky.social while taking in the @ciccheminst.bsky.social #CSC2025 in Ottawa - 🇨🇦 this week. #SSNMR 🧲 @brphan17.bsky.social @arkady-p.bsky.social - some fantastic chemistry presentations coming out of @ualberta.bsky.social ! 🥼🥽 🧪

I'm happy to release my first version of BenMR, a software toolkit that performs some common calculations used in solid-state NMR. It is written in Python and can be installed as a Windows app. It is available on my GitHub page:
🔗https://github.com/benMRmagnet/SSNMR-Calculator

#NMRchat #SSNMR

I asked ChatGPT to generate an image of me based on its memory. When I told ChatGPT I don't smoke cigarettes, it subbed in a cigar. 🤔 I guess AI thinks smoking is sophisticated.

At least it got the NMR magnet right, though! And yes, reading The Economist is one of my hobbies. #ssnmr

Brian, Arkadii and Kishor - trying to record some spins @ 9.4T 🧲 - #science 🧪 springtime fun with #SSNMR @ualberta.bsky.social - Wicked Lab Wednesdays'

Congratulations to Madhu for successfully defending his PhD in April in #SSNMR and its application to sustainable energy materials! Our team is cheering you on and wishes you all the best in your next adventure as a PDF at NYU in the Avalos NMR Group! 🧲🧪🍾 🇳🇵@ualberta.bsky.social #chemsky

Summary - CCP-NC ML for NMR Workshop. Online registration by Cvent

📢 Machine Learning in NMR crystallography

A few spaces remaining - register now to secure your spot!

🗓️ 13-14th May
📍 Manchester
🔗 Register here: cvent.me/oMQzMK

Bring your #SSNMR problems and your #MachineLearning solutions. #NMRchat #NMR