Bacteriophages are in a constant arms race with bacteria 🦠 The Phage ORFeome pooled library from the Aaron Whiteley lab contains phage proteins that activate antiphage defense systems — a tool to dissect the mechanisms of bacterial immunity. Aaron Whiteley

Synthetic microbial co-cultures for modular bioelectronic sensing in diverse environments - Nature Biotechnology Modular integration of bacterial strains expands the application range of whole-cell bioelectric sensors.

Synthetic microbial co-cultures for modular bioelectronic sensing in diverse environments go.nature.com/48bpVhg

We have some fresh and cool #glycotime 🧪 on the impact of including glycosylation explicitly in de novo binder design. Filtering the results of a recent open competition for novel binders to the Nipah Virus Glycoptrotein (NiV-G) with ReGlyco improves the pipeline efficiency significantly ⬇️

Chemical dialogues at the crossroads of host–bacteria interactions Microbiomes are now recognised as the second genome of eukaryotes, providing diverse life-support functions for their hosts. The impact of microbiome …

#microsky #microbiomesky

www.sciencedirect.com/science/arti...

A bacterial CARD–NLR-like immune system controls the release of gene transfer agents - Nature Microbiology An immunity-like system functions as a lysis control hub to promote gene transfer agent particle release from host bacterial cells, suggesting that bacterial immune systems may be co-opted to promote ...

#microsky #MGE and kinda #phagesky #phage

Control of GTA release in Caulobacter by the @tunglejic.bsky.social lab.

www.nature.com/articles/s41...

Our team received a report of intermittent app outages at about 11:40pm PDT on April 15, 2026. They worked through the night to mitigate a sophisticated Distributed Denial-of-Service (DDoS) attack, which intensified throughout the day.

#glycotime #glycotimesky #microsky

Beautiful work on the XylE MFS transporter by the Drew lab (transporters matter :-) ).

www.nature.com/articles/s41...

Oh, yeah: one could see it coming from miles away yet having it here now is exhilarating!

Diversity-generating retroelements for programmable targeted hypermutagenesis - Nature Biotechnology Diversity-generating retroelements are engineered for directed evolution in E.coli.

#synbiosky #microsky #phagesky

www.nature.com/articles/s41...

#microsky #phagesky

Jumbo #phage PhiKZ

www.nature.com/articles/s41...

Kate Clinch Karenia Scholarship ( UTS scholarship) at University of Technology Sydney on FindAPhD.com PhD Project - Kate Clinch Karenia Scholarship ( UTS scholarship) at University of Technology Sydney, listed on FindAPhD.com

Interested in doing a PhD to help solve the South Australian Karenia cristata toxic algal bloom problem? Applications close next week and project start is mid 2026 (July/August). A great opportunity to work with the amazing Shauna Murray (@shaunamurray.bsky.social)

www.findaphd.com/phds/project...

Check out our review on epithelial–microbiome interactions and their disruption in inflammatory skin disorders. + computational tools to study host–microbe crosstalk + ecological memory (epithelial and microbial memories) in barrier tissues. www.nature.com/articles/s41...

A family of endonucleases blocks nanotube-mediated plasmid exchange - Nature Microbiology The YokF endonuclease provides a donor-controlled mechanism to limit plasmid transfer to recipient bacteria via nanotubes in Bacillus subtilis, with YokF functional homologues found across Gram-positi...

#microsky #phagesky #MGE

A prophage-encoded endonuclease blocks plasmid transfer between bacterial cells

www.nature.com/articles/s41...

Protein and genomic language models uncover the unexplored diversity of bacterial immunity The bacterial pangenome contains a vast diversity of antiphage systems, whose overall extent is still unknown. In this study, we developed complementary machine learning approaches to systematically p...

#microsky #phagesky #phage defence

www.science.org/doi/10.1126/...

#microsky #phagesky

Temperate #phage better than lytic at infecting E. coli biofilms

journals.plos.org/plosbiology/...

Efflux pumps just got even more complicated! Beautiful evidence from Ben Luisi & team of another protein (YbjP) that is part of RND efflux pump complexes and associates with the outer membrane channel! Function unclear, but super interesting 🤩 elifesciences.org/reviewed-pre...

#microsky #phagesky on #phage cocktails

Bacterial physiology and self-organization through the lens of physics This Collection aims to bring together research from diverse aspects of physical biology, focusing on the interplay of physical laws and bacterial behaviour ...

@commsphys.nature.com Collection open for submission on Bacterial physiology and self-organization through the lens of physics

Editors: Eleonora Secchi, Anupam Sengupta & Kazumasa Takeuchi

www.nature.com/collections/...

#Bacterial_motility #Biofilm #Bacterial_interactions #Self_organisation

Bacteria covalently incorporate polyfluoroalkyl carboxylates into membrane lipids - Nature Microbiology Bacteria are able to covalently incorporate n:3 polyfluoroalkyl carboxylates into phosphatidylethanolamine and phosphatidylglycerol, two major components of bacterial lipid bilayers.

#microsky

www.nature.com/articles/s41...

#microsky Tour de force from the @pmoyniha.bsky.social @lislowe.bsky.social & @proftracypalmer.bsky.social labs on the Type VII secretion in Mycobacteria 🎉👏👏👏

Mine was a minuscule contribution, flattered to feature.

www.biorxiv.org/content/10.6...

from: https://smallthingsconsidered.blog/schaechter/2023/06/anything-found-to-be-true-of-e-coliem-must-also-be-true-of-elephants/

"Anything found to be true of 𝘌. 𝘤𝘰𝘭𝘪 must also be true of elephants." (j. monod) "...but certainly not for 𝘉. 𝘴𝘶𝘣𝘵𝘪𝘭𝘪𝘴" (picked up by @emmseveri.bsky.social at a meeting), and also not for 𝘈𝘤𝘪𝘯𝘦𝘵𝘰𝘣𝘢𝘤𝘵𝘦𝘳, as @ckellison.bsky.social et al. found out now

Night view of Belfast City Hall illuminated with colourful lights, promoting registration for Annual Conference 2026 at ICC Belfast from April 13-16.

Annual Conference is the UK's largest annual gathering of microbiologists. Register now to secure your spot: https://microb.io/AC26Register #Microbio26

#microsky #phagesky #phage

www.nature.com/articles/s41...

Generating 3D models of complex carbohydrates with GLYCAM-Web - Nature Methods GLYCAM-Web offers a suite of validated 3D oligosaccharide structure modeling tools via a convenient web server.

#glycotime #glycotimesky

www.nature.com/articles/s41...

#microsky #phagesky #MGE

Capturing dynamic phage–pathogen coevolution by clinical surveillance - Nature The acquisition of a parasitic anti-phage mobile genetic element, PLE11, showing potent anti-phage activity against cocirculating ICP1, and the subsequent evolution of ICP1 to escape this defense, are...

#microsky #phagesky #phage

www.nature.com/articles/s41...

Clostridia from preterm infants metabolize human milk oligosaccharides to suppress pathobionts and modulate intestinal function in organoids - Nature Microbiology Clostridium perfringens lacking perfringolysin O toxin isolated from preterm infants metabolizes human milk oligosaccharide disialyllacto-N-tetraose to produce metabolites that promote the growth of c...

#microsky #microbiomesky #microbiome

From Chris Stewart’s lab with a sialic acid twist

www.nature.com/articles/s41...

#microsky #phagesky #phage

Do you know a paper describing evolution of (enhanced) biofilm formation upon phage exposure?
Thus not an experiment where biofilm is used for EE, but EE of a bacterial population leading to protection against phage via biofilm matrix/aggregation/etc

Asking for a friend's teaching lecture

A modular biodevice assembly tool kit for combinatorial screening and benchmarking multiple cell surface display platforms in Escherichia coli - Journal of Biological Engineering Journal of Biological Engineering - Bacterial cell surface display is a versatile platform technology for synthetic biology applications. A successful display platform often requires ad hoc testing...

#microsky #synbiosky

link.springer.com/article/10.1...