Good morning!! This week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
Highlight: Systems-level organization of extracellular proteostasis www.science.org/doi/10.1126/...
Registration now open! 2026 #EMBO #Ubiquitin Workshop set in stunning Monopoli, Puglia 🇮🇹
Cutting edge science, great speakers, short talk opportunities, travel awards
Limited spaces. Dont miss out - register early!
Registration & more info: meetings.embo.org/event/26-ubi...
The E3 ubiquitin ligase mechanism specifying target-directed microRNA degradation (TDMD) is now published! 🎉🍾 We, @bartellab.bsky.social and Schulman lab, describe how 2-RNA factors control protein degradation by recruiting an E3 ligase. @mpibiochem.bsky.social
www.nature.com/articles/s41...
Join us for the #Ubiquitin & Friends Symposium 2026, April 29-30, in Vienna!
Fantastic guest speakers👇 & many slots for talks from abstracts, flash-talks & posters. Lots of opportunities to network. Register now to save your spot!
➡️ www.protein-degradation.org/symposium/
#ubfriends2026
Molecular glue degraders don't just block proteins; they reprogram cellular recognition logic to eliminate "undruggable" targets entirely.
Clues for Glues review by @zkozicka.bsky.social
doi.org/10.1042/EBC2...
1 week to go! Würzburg's ready - are You? The GRK2243 Symposium 2025 is just around the corner. Pack your bags, prep your slides, and get hyped!
#wUeBI2025
Excited to share our latest study on how K29/K48-branched #ubiquitin chains are forged by the #E3 ligase TRIP12, and how this suggests a consensus mechanism for chain formation by HECT E3s!
@natsmb.nature.com
1/7
www.nature.com/articles/s41...
👏 Fantastic talk by Professor Craig Crews @craigmcrews.bsky.social at the Lund Spring Symposium on the past and future of PROTACs!
🎉 Congratulations on receiving The Special Achievement Award — well-deserved recognition for major contributions to TPD!
#TPD #PROTAC #LundSpringSymposium
🗺️ Interactive Map Update!
2 new UK-based labs have been added to the global TPD map:
🔹 Kessler Lab @kesslerbenedikt001.bsky.social
🔹 Fletcher Lab
Explore these and many other TPD and ubiquitin labs:
👉 tpd-community.com
#TPD #ProteinDegradation #Ubiquitin
🗺️ Interactive Map Update!
The Münch Lab @cmunch.bsky.social has joined the global TPD map! 🎉
Explore their work and discover other labs studying #TPD and #ubiquitin biology.
👉 tpd-community.com
#ProteinDegradation
🗺️ Interactive Map Update!
The map was just updated with 3 more labs from Germany working on TPD:
🔹 Hausch Lab
🔹 Knapp Lab
🔹 Gersch Lab @maltegersch.bsky.social
Explore these and other labs advancing TPD and ubiquitin biology:
👉 tpd-community.com
#TPD #ProteinDegradation #Ubiquitin
Great to see this out. A story that spanned continents, cities and budget codes…
www.nature.com/articles/s41...
Big thanks to all the teams involved!
@clausenlab.bsky.social @e3chembio.bsky.social
🔬 Lab Spotlight: Malte Gersch Lab at Max Planck & TU Dortmund @maltegersch.bsky.social
Recent paper: New insights into DUB inhibition & crystallization! 👉 www.nature.com/articles/s41...
🧬 Exploring degraders? Check out PROTAC-DB — a free, searchable resource with data on 3,200+ PROTACs, warheads, linkers, E3 ligands, and more.
Includes binding data, degradation metrics, ternary structures, and WB images.
🔗 Dive in: cadd.zju.edu.cn/protacdb/
#PROTAC #TPD #DrugDiscovery
Day 1 one #ubfriends2025 was full of great 🎤talks, creative elevator pitches, lively poster sessions and stimulating discussions...
🗺️ TPD Research Map Update!
5 new labs just joined the global TPD map:
🔹 Slabicki Lab
🔹 Kaneko Lab
🔹 Wiener Lab
🔹 Korenblit Lab
🔹 Zhuang Lab
Explore these and many other labs working on targeted protein degradation and ubiquitin biology!
👉 tpd-community.com
#TPD #ProteinDegradation #Ubiquitin
📢 Next week at the DFCI TPD Seminar (May 15, 12PM EST):
🎙️ Talks by Rebecca Metivier and Martin Steger on using mass spec proteomics to uncover degrader targets.
Don’t miss it!
#TPD #Proteomics #Degraders
PVDF vs Nitrocellulose? How to Choose a Blot Membrane 🤔
If you're optimizing your blots, this guide from Fisher Scientific breaks down when and why membrane matters:
📌 Also includes practical tips for handling and troubleshooting.
#WesternBlot #LifeScienceTips
🔬 New from the Itay Koren lab:
💥 TOM20 anchors an E3 ligase to drive UPS-dependent control of mitochondrial fusion/fission via PLD6 degradation.
doi.org/10.1038/s415...
👏 Congrats to all authors!
📍 Find the Koren lab + others on our map: tpd-community.com
#Ubiquitin #ProteinDegradation
🚨 Next week!
The Ubiquitin & Friends Symposium 2025 in Vienna 🇦🇹, May 8–9!
Great science, great people, and great event for anyone into ubiquitin & TPD.
🔗 www.protein-degradation.org/symposium/
👥 Organizers: @sfb-tpd-vienna.bsky.social
#TPD #Ubiquitin #ProteinDegradation
🔬 GRK2243 Symposium – Understanding Ubiquitylation
📅 June 2–4, 2025
📍 Würzburg, Germany
A 3-day deep dive into ubiquitin biology—from molecular mechanisms to disease and therapeutic strategies.
👥 Hosted by @GRK2243
🔗 Full info: www.ubiquitin-wuerzburg-2025.de
#TPD #Ubiquitin #wUeBI2025
🧬 Want to see who’s working on Targeted Protein Degradation or ubiquitin biology?
🔍 Explore our interactive map of research labs worldwide:
🌐 tpd-community.com#the-map
Discover labs and find collaborators.
#TPD #Ubiquitin #ProteinDegradation #ResearchMap
Welcome to the hub of Targeted Protein Degradation (TPD) and ubiquitin biology.
👋 Connecting the global TPD & ubiquitin biology community.
🔬 Find labs, discover events, and stay in the loop.
🌐 tpd-community.com
#TPD #Ubiquitin #ProteinDegradation