Recyclable Protein Degraders Could Boost Cancer Immunotherapy - 2025 Innovation Award Nominee Quanyin Hu, assistant professor of pharmacy, and postdoctoral researcher Peixin Liu have developed McR-TACs, a new class of protein degrader that targets disease-related proteins on and outside cells.

Associate Professor Quanyin Hu & postdoctoral researcher Peixin Liu have been nominated for a 2025 @warfnews.bsky.social Innovation Award! The nomination honors their development of McR-TACs, a recyclable class of protein #degraders targeting disease-related proteins. https://bit.ly/4rm6pW0 #SciSky

Targeted protein degradation for cancer therapy - Nature Reviews Cancer Targeted protein degradation (TPD) is an emerging pharmacological modality in cancer therapy. In this Review, Hinterndorfer et al. outline the mechanistic bases of TPD and discuss the characteristics, advantages and applications of established compounds as well as upcoming classes of degraders.

🥳 Our 2nd most downloaded article in 2025:

Targeted protein degradation for cancer therapy

#PROTACs #Degraders @NatResCancer
#NRCtop10of2025

Heading to #SLAS2026 today? Make sure you catch our East Coast BDM, Jake Isaacs, on the Topical Interest Group #ProximityAssays panel discussion "From #Degraders to PPI Modulators: The Expanding Universe of Proximity Medicines" at 1pm in room 204AB 💡

Monte Rosa Therapeutics Announces Collaboration with Novartis for Degraders to Treat Immune-mediated Diseases Monte Rosa Therapeutics Announces Collaboration with Novartis for Degraders to Treat Immune-mediated Diseases ...

Monte Rosa Therapeutics $GLUE announces collaboration with Novartis for molecular glue #degraders to treat immune-mediated diseases

2nd partnership between the 2 companies, now including $120M upfront and up to $5.7 billion total deal

#biotech #immunology

www.globenewswire.com/news-release...

To enable their systematic discovery, we addressed this urgent need with matched chemical pairs of DUB inhibitor and #degraders by focusing on USP7 as a case study. By using potent and selective modulators, we aimed to dissect phenotypes induced by inhibitors and degraders of USP7 in solid cancers.

Lmao it’s funny we both #degraders I let him shine SOMETIMES ✨😅🤣☠️

📢 Next week at the DFCI TPD Seminar (May 15, 12PM EST):

🎙️ Talks by Rebecca Metivier and Martin Steger on using mass spec proteomics to uncover degrader targets.

Don’t miss it!

#TPD #Proteomics #Degraders

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🎧 Listen: lnkd.in/gpK4BkuD

#Degraders #PROTACs #DrugDiscovery #OpenScience #PodcastSeries

Importantly, the authors don't observe alkylamine biotransformation into an electrophilic aldehyde as has been reported for other FBXO22-recruiting #degraders.

Aram Davtyan giving an awesome poster presentation about our work modeling protein-small molecule-protein ternary complexes at @keystonesymposia.bsky.social Proximity-Based Therapeutics! #biotech #drugDev #degraders #molecularGlues #PROTACs

Find the poster here: www.deeporigin.com/academic-pos...

Eliminating Aggressive Cancers via PROTAC-like Inducers of Ferroptosis Aggressive and therapy-resistant cancers present a significant challenge to treatment and are associated with poor patients survival. Identifying molecular pathways and compounds that target these pat...

Have a look at this exciting #collaborative #work by Amir Orian, Ashraf Brik Technion Haifa and @diefenbacherlab.bsky.social@www.helmholtz.de on #PROTAC like #degraders to deplete aggressive tumor cells! #ubiquitin and #degradation are indeed #promising #therapeutics www.biorxiv.org/content/10.1...

Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets Nature Communications - Autophagosome tethering compounds (ATTECs) are small molecule degraders hijacking the autophagy system. Here, the authors show that current ATTEC ligands did not bind to...

For aficionados of #fragments, #degraders & #ATTECs. Learn how biophysics approaches - spectral shift detection on #NanoTemper Dianthus characterised LC3/GABARAP interactions.
From #GoetheUniversity, #SGC, #DKTK, #DKFZ. #Fraunhofer #TUM #DiamondLightSource, Nathan Adams & Ivana Jaser

rdcu.be/d22DS