Our Spring PhD call is OPEN! 30+ fully funded positions & diverse life science subjects. Check out the openings at the Max Perutz Labs 👉 www.vbcphd.at
Apply now!
Institute of Molecular Biotechnology, Max Perutz Labs Vienna, IMP, Gregor Mendel Institute of Molecular Plant Biology

(1/8)
I’m excited to share that our work is now published in The EMBO Journal!

Ki-67 shapes the nucleolus by anchoring chromatin via its amphiphilic properties

A short summary is in the thread below, or you can jump straight to the paper here.
link.springer.com/article/10.1...

Ki-67 shapes the nucleolus by anchoring chromatin via its amphiphilic properties - The EMBO Journal The nucleolus, a membrane-less organelle essential for ribosome biogenesis, adopts variable shapes across cell types and in response to environmental conditions, yet the mechanisms regulating its morp...

Extremely happy to see this wonderful story out! 🔬

Here, we describe how Ki-67 anchors chromatin to nucleoli, leading them to acquire irregular shapes!!! 🫧🧬

This great story was led by Daja Schichler & Yuki Hayashi from the Cuylen Lab @embl.org

link.springer.com/article/10.1...

Ki-67 shapes the nucleolus by anchoring chromatin via its amphiphilic properties - The EMBO Journal The nucleolus, a membrane-less organelle essential for ribosome biogenesis, adopts variable shapes across cell types and in response to environmental conditions, yet the mechanisms regulating its morp...

Why do nucleoli adopt irregular shapes despite their liquid-like nature?
Sara Cuylen-Häring and colleagues find that Ki-67 mediates this irregularity by tethering chromatin at the surface and creating internal chromatin invaginations
link.springer.com/article/10.1...

You asked, we listened. Millions of AI-predicted protein complex structures are now available in the #AlphaFold Database.

This spans homodimers from 20 of the most studied species, including humans, as well as the World Health Organization’s priority pathogens list.

www.ebi.ac.uk/about/news/t...

Microscope images of Ryugu samples collected from the first and second touchdown sites of the Hayabusa2 mission, respectively. Credit: JAXA / JAMSTEC

The complete set of nucleobases found in terrestrial DNA and RNA — adenine, guanine, cytosine, thymine and uracil — have been detected in samples returned from the asteroid Ryugu, according to research in Nature Astronomy. go.nature.com/3P9A9YN 🔭 🧪

Lab Manager - Stuart Group The European Molecular Biology Laboratory (EMBL) is one of the world’s leading life science research organisations. With sites across Europe, EMBL fosters an international, collaborative, and inclusiv...

Are you fascinated by self-organised patterning processes?

The brand-new Stuart lab at EMBL Barcelona is looking for a lab manager!

Hannah @htstuart.bsky.social is a fantastic scientist and mentor. Building the lab with her will be a lot of fun!

embl.wd103.myworkdayjobs.com/EMBL/job/Bar...

🚨TLM HYBRID SEMINAR🚨
18/03/2026 (16:00 UK) Dr. Karina Pombo from @rosfrankinst.bsky.social will be presenting: “Membrane prewetting by condensates promotes tight-junction belt formation” at Yusuf Hamied Department of Chemistry (Wolfson Lecture Theater)
@pombo-garcialab.bsky.social

We‘re looking for a motivated Master student to join our team!

Do you want to optogenetically control metabolic activity to see how metabolism affects patterning and morphogenesis? 💡🧫🧬🔬

Then please apply!
#optogenetics #metabolism #devbio #hESCs

Please RT. Thank you!🙏

Job Opening: Master's project in environmental and metabolic regulators of embryonic development

Apply to the Master’s project position at IMBA: www.oeaw.ac.at/imba/career-education/op...

#research #jobs #europe #biology

We are hiring!
Come work with us as a Laboratory Technician at IBEC in sunny Barcelona! We offer a one-year contract, with the possibility of extension for up to two additional years.
Please help spread the word! Feel free to contact me if you have any questions.
ibecbarcelona.eu/laboratory-t...

High-content screening of organoids reveals the mechanisms of human pancreas acinar specification Keshara et al. conducted a high-content screen on pancreas organoids that identified 54 compounds affecting differentiation or morphogenesis. After validating 11 compounds, they focus on Gsk3A/B inhibitors, which, combined with FGF withdrawal, drive acinar cell differentiation, enabling future studies on these cells and their role in cancer initiation in humans.

High-content screening of organoids reveals the mechanisms of human pancreas acinar specification

Permeability-driven pressure and cell proliferation control lumen morphogenesis in pancreatic organoids - Nature Cell Biology Using pancreatic organoids, Lee et al. show that the balance between epithelial tissue permeability-driven lumenal pressure and cell proliferation affects ductal morphogenesis.

☕Using #pancreatic #organoids, Lee et al. show that the balance between epithelial tissue permeability-driven lumenal pressure and cell proliferation affects ductal morphogenesis.
bit.ly/4qozmjG

I’m very excited to share that our paper has been recently published in Cell Stem Cell! 🎉 🧫

In this study, using high-content imaging–based organoid screening, we discovered growth media conditions that drive differentiation into functional pancreatic acinar cells.

doi.org/10.1016/j.st...

Last chance to submit your abstract for 'Cellular mechanisms driven by phase separation'! Let's tackle emerging questions in cellular organisation, adaptation, and robustness together 🧬🦠 #EESPhaseSeparation

19 – 22 May 2026

Submit your abstract by 10 Feb: s.embl.org/ees26-08-bl

The Elbe Program is offering positions for independent postdocs at the interface between theory (physics, maths, computing) and biology. Join us in Dresden! Deadline 13 March.

Work for us Working for us We’re always looking for talented and motivated people to work as part of our close-knit team. Roles range from editorial to production, marketing to event co-ordination, HR to accounts...

We're hiring! JCS is looking for a Reviews Editor to join the team. This is a fantastic opportunity for someone who loves cell biology and wants to stay connected with the field (and be part of an organisation that believes in supporting the community).
www.biologists.com/about-us/wor...

🔔HIRI has opened a new call to recruit Group Leaders. If you are interested in opening an RNA Biology and Infection lab, join us! Deadline: February 15. More info here 👇

The spring call for the ELBE Postdoctoral Fellows Program is open now: www.csbdresden.de/join-us/as-a.... Join the @csbdresden.bsky.social for a fully funded fellowship. @mpi-cbg.de @mpipks.bsky.social

You have a background in math/physics/computer science/ML and are looking for an interdisciplinary postdoc fellowship in life sciences with free choice of host groups? Then join us at the CSBD as an ELBE postdoc! The application deadline is the 13 of March

I am recruiting postdoctoral fellows to develop new research directions in the lab. We study transcriptional regulation through biomolecular condensates in development and disease, with an emphasis on first-principles and mechanistic discovery. Please repost or share with colleagues.

Congratulations to Rashmi and Karolina and also to the technology development studio of the MPI-CBG without whom the screen would not have been possible.
If you are interested in high-content screening in organoid models, you may want to take a look.

High-content screening of organoids reveals the mechanisms of human pancreas acinar specification Keshara et al. conducted a high-content screen on pancreas organoids that identified 54 compounds affecting differentiation or morphogenesis. After validating 11 compounds, they focus on Gsk3A/B inhibitors, which, combined with FGF withdrawal, drive acinar cell differentiation, enabling future studies on these cells and their role in cancer initiation in humans.

Online Now! High-content screening of organoids reveals the mechanisms of human pancreas acinar specification #stemcells

High-content screening of organoids reveals the mechanisms of human pancreas acinar specification Keshara et al. conducted a high-content screen on pancreas organoids that identified 54 compounds affecting differentiation or morphogenesis. After validating 11 compounds, they focus on Gsk3A/B inhib...

Publication in @cp-cellstemcell.bsky.social: www.cell.com/cell-stem-ce...

Making human pancreatic acinar cells Dresden researchers develop novel methods to create acinar cells, which are involved in the formation of pancreatic cancer.

The group of @anne-grapin.bsky.social developed methods to create functional acinar cells, which are involved in the formation of pancreatic cancer. Rashmiparvathi Keshara, Karolina Kuodyte, and the TDS facility used image-based screen & robust analysis pipeline. www.mpi-cbg.de/news-outreac...

Short linear motifs - Unexplored players driving Toxoplasma gondii infection Pathogens infect hosts by interacting with host proteins and exploiting their functions to their advantage. Short linear motifs, small functional regions within intrinsically disordered protein regions, are common mediators of host-pathogen protein interactions. While motifs have been more extensively studied in viruses and bacteria, the extent to which eukaryotic unicellular parasites use motifs during infection remains unexplored. Toxoplasma gondii is a widespread intracellular Apicomplexan parasite capable of infecting all warm-blooded animals and invading any of their nucleated cells. Toxoplasma's secreted proteins are key in interacting with host proteins during infection, making them potential sources for motifs. To highlight the role of motifs in Toxoplasma gondii infection, we curated 20 known motif instances in Toxoplasma proteins from the scientific literature. To identify more motifs in Toxoplasma secreted proteins, we developed a computational pipeline that annotates putative motif matches with structural and functional features. Through this approach, we identified a set of 27,832 motif matches in 296 secreted proteins. We highlight strategies for further prioritisation of likely functional motif matches by focusing on integrin motifs, degrons and TRAF6-binding motifs. We subjected four predicted TRAF6-binding motifs to experimental validation, supporting the predicted motifs in the Toxoplasma proteins RON10 and GRA15. Our motif predictions provide a valuable resource for generating hypotheses and designing experiments to study infection mechanisms. The characterisation of motifs in Toxoplasma will be key to understanding the molecular principles underlying its broad host range and more comprehensive Apicomplexan infection strategies. ### Competing Interest Statement The authors have declared no competing interest. Deutsche Forschungsgemeinschaft, 449991970

New preprint! Here, we highlight the role of motifs during the Toxoplasma host cell invasion, predict thousands of motifs in its effector proteins, and validate the binding of TRAF6 motifs. Our results are intended to catalyse further research on motifs and parasites.
www.biorxiv.org/content/10.6...

Congratulations, Julia Mahamid!

Julia Mahamid receives the @dfg.de Leibniz Prize for her work on structural cell biology!

#LeibnizPreis

Toxoplasma effector TgROP1 establishes membrane contact sites with the endoplasmic reticulum during infection - Nature Microbiology The Toxoplasma gondii effector TgROP1 mimics host factors to bind VAPA/B, thereby establishing parasite–host ER contact sites.

During host cell invasion, Toxoplasma mimics the FFAT motif and repurposes it to associate its parasitophorous vacuole to the endoplasmic reticulum!

I'm happy to have been part of this work! Congratulations to Chahat Mehra and Lena Pernas for all the hard work!
www.nature.com/articles/s41...

Our Science paper is out!

Huge congratulations to @huabin-zhou.bsky.social, Mike Rosen, and the brilliant @janhuemar.bsky.social @juliamaristany.bsky.social and @kieran-russell.bsky.social from our group

News: bit.ly/4avnkAr and bit.ly/3XBGVHS

Great perspective by @vram142.bsky.social +K Zhang

Super excited to share that our paper is now out in @science.org. Lots of work, but also lots of fun getting this out.
Be sure to check it out!
www.science.org/doi/10.1126/...
Also, follow:
@huabin-zhou.bsky.social @juliamaristany.bsky.social @kieran-russell.bsky.social @rcollepardo.bsky.social