Gilead to buy Germany's Tubulis for up to $5 billion to boost cancer pipeline Gilead said on Tuesday it would acquire Germany-based Tubulis GmbH for ​up to $5 billion, as it looks to strengthen its cancer drugs ‌pipeline.

Gilead to buy Germany's Tubulis for up to $5 billion to boost cancer pipeline reut.rs/47IznIH

Vitamin B2 metabolism promotes FSP1 stability to prevent ferroptosis - Nature Structural & Molecular Biology Here, Deol et al. use genetic screens in gene-edited reporter cell lines to identify regulators of ferroptosis suppressor protein 1 (FSP1) expression and stability. They show that vitamin B2 metabolis...

1/3 Thrilled to see our paper led by Kirandeep Deol is out in Nature Structural & Molecular Biology! CRISPR screens to uncover a role for vitamin B2 metabolism in stabilizing FSP1 via FAD, revealing a new way vitamins regulate ferroptosis.
www.nature.com/articles/s41...

N‐Alpha‐Acetyltransferase 30, Transcriptionally Regulated by NR2C2, Promotes Ovarian Cancer Progression by Mediating ARPC1B Acetylation In ovarian cancer, transcription factor NR2C2 is highly expressed and enhances the transcription of NAA30. This subsequently suppresses the ubiquitination of ARPC1B, leading to its protein stabilizat...

faseb.onlinelibrary.wiley.com/doi/10.1096/...

www.nature.com/articles/s41...

smartbax announces a €4.7 M Pre-Series A round to advance novel antibiotic compound through preclinical stage Lead antibacterial compound against a novel target in Gram-negative bacteria validated in infection modelsProgressing a platform of small-molecule...

Great news from smartbax — they’ve raised €4.7M Pre-Series A to advance their novel antibiotic through preclinical development!

We’re proud at INCATE to have supported them early on and thrilled to see their progress in the fight against #AMR.

Read more 👉 www.globenewswire.com/news-release...

NAA60 facilitates LRRC8A- and LRRC8D-mediated platinum drug uptake - Communications Biology Genome-wide CRISPR/Cas9 screening identifies the N-terminal acetyltransferase NAA60 to facilitate cis- and carboplatin drug sensitivity, most likely by neutralizing Nt acetylation of the LRRC8A/D VRAC subunits regulating substrate permeability.

www.nature.com/articles/s42...

Genetic suppression features ABHD18 as a Barth syndrome therapeutic target - Nature The enzyme ABHD18 is shown to have a key role in cardiolipin metabolism in mitochondria, offering a potential route for a small-molecule treatment of the rare genetic disease Barth syndrome.

Very happy to be part of this amazing work from Jason Moffat and Sanna Masud - Victoria Saba Echezaretta's rescue experiments are remarkable. www.nature.com/articles/s41...

Degrons: defining the rules of protein degradation - Nature Reviews Molecular Cell Biology Degrons allow E3 ubiquitin ligases to identify their substrates, and thus have a central role in protein degradation by the ubiquitin–proteasome system. This Review discusses the latest insights into ...

www.nature.com/articles/s41...

Acetylhistidine in our blood can prevent kidney disease and is produced by the HisAT (NAT16) enzyme displaying a rare double-GNAT structure. Great efforts by Matti Myllykoski and the rest of the team at @unibergen.bsky.social to get this published. #acetyltransferase www.nature.com/articles/s41...

Acylamino acid-releasing enzyme (AARE), a bifunctional protease with a potential role in aging Abstract. Acylamino acid-releasing enzyme (AARE) is an evolutionary deeply conserved bifunctional serine protease. In its exopeptidase mode, AARE cleaves N

Happy to present our latest review article, just out in @jxbotany.bsky.social!
Acylamino acid-releasing enzyme (AARE), a bifunctional protease with a potential role in #aging
@cibss.bsky.social @biologyunifreiburg.bsky.social
academic.oup.com/jxb/advance-...

Dysregulation of N-terminal acetylation causes cardiac arrhythmia and cardiomyopathy - Nature Communications N-terminal acetylation dysregulation in the heart causes severe arrhythmia and cardiomyopathy. The authors show that stem cell models demonstrate ion channel trafficking defects and sarcomeric disarra...

www.nature.com/articles/s41...

Harvard has set an example for other higher-ed institutions - rejecting an unlawful and ham-handed attempt to stifle academic freedom, while taking steps to make sure students can benefit from an environment of intellectual inquiry, rigorous debate and mutual respect. Let’s hope others follow suit.

UBE2M depletion reduces LC3B neddylation, leading to its destabilization, impaired autophagic activity and skin aging! Cool paper out in @pnas.org

www.researchsquare.com/article/rs-6...

MYC-Targeting PROTACs Lead to Bimodal Degradation and N-Terminal Truncation MYC is a master regulatory transcription factor whose sustained dysregulation promotes the initiation and maintenance of numerous cancers. While MYC is a regarded as a potenial therapeutic target in cancer, its intrinsically disordered structure has proven to be a formidable barrier toward the development of highly effective small molecule inhibitors. We rationalized that proteolysis targeting chimeras (PROTACs), which might accomplish the targeted degradation of MYC, would achieve more potent cell killing in MYC-driven cancer cells than reversible inhibitors. PROTACs are bifunctional small molecules designed to produce a ternary complex between a target protein and an E3 ligase leading the target’s ubiquitination and degradation by the 26S proteasome. We generated PROTAC MTP3 based on modifications of the previously reported MYC-targeting compound KJ-Pyr-9. We found that MTP3 depletes endogenous full-length MYC proteins and uniquely induces increasing levels of a functional, N-terminally truncated MYC species, tMYC. Furthermore, MTP3 perturbs cellular MYC levels in favor of a tMYC-dominated state whose gene regulatory landscape is not significantly altered compared to that of wild type MYC. Moreover, although it lacks ∼10 kDa of MYC’s N-terminal transactivation domain, tMYC is sufficient to maintain an oncogenic proliferative state. Our results highlight the complexities of proximity-inducing compounds against highly regulated and conformationally dynamic protein targets such as MYC and indicate that PROTACs can induce alternative outcomes beyond target protein degradation.

MYC-Targeting PROTACs Lead to Bimodal Degradation and N-Terminal Truncation | ACS Chemical Biology pubs.acs.org/doi/10.1021/...

Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins Breakdown of every transmembrane protein trafficked to lysosomes requires proteolysis of their hydrophobic helical transmembrane domains. Combining lysosomal proteomics with functional genomic dataset...

Amazing story from #MolecularTherapeutics faculty @robzonculab.bsky.social with lead author @aakritijain.bsky.social describing membrane protein degradation in the lysosome. Congratulations!!

www.science.org/doi/10.1126/...

UbiREAD deciphers proteasomal degradation code of homotypic and branched K48 and K63 ubiquitin chains Ubiquitin chains determine the fates of their modified proteins, including proteasomal degradation. Kiss et al. present UbiREAD, a technology to monitor cellular degradation and deubiquitination at hi...

Super excited to share our latest work on deciphering the #Ubiquitin Code

“𝗨𝗯𝗶𝗥𝗘𝗔𝗗 𝗱𝗲𝗰𝗶𝗽𝗵𝗲𝗿𝘀 𝗽𝗿𝗼𝘁𝗲𝗮𝘀𝗼𝗺𝗮𝗹 𝗱𝗲𝗴𝗿𝗮𝗱𝗮𝘁𝗶𝗼𝗻 𝗰𝗼𝗱𝗲 𝗼𝗳 𝗵𝗼𝗺𝗼𝘁𝘆𝗽𝗶𝗰 𝗮𝗻𝗱 𝗯𝗿𝗮𝗻𝗰𝗵𝗲𝗱 𝗞48 𝗮𝗻𝗱 𝗞63 𝘂𝗯𝗶𝗾𝘂𝗶𝘁𝗶𝗻 𝗰𝗵𝗮𝗶𝗻𝘀”

@cp-molcell.bsky.social

1/8

www.cell.com/molecular-ce...

How can we close the early discovery gap and improve our ability to discover new antibiotics? - by Olga Genilloud PLEASE NOTE: The Viewpoints on our website are to be read and freely shared by all. If they are republished, the following text should be used: “This Viewpoint was originally published on the REVIVE w...

Early-stage antibiotic discovery happens mostly in academia, but limited funding and expertise hinder its translation into preclinical development.
In her REVIVE @gardp.bsky.social article, Olga Genilloud explores solutions to these issues.

🔗 Read more: revive.gardp.org/how-can-we-c...

Acetylation: a new target for protein degradation in cancer Acetylation is an increasing area of focus for cancer research as it is closely related to a variety of cellular processes through modulation of histone and non-histone proteins. However, broadly targ...

www.cell.com/trends/cance...

Antibiotikaresistens Informasjon om bruk av antibiotika Nasjonalt senter for antibiotikabruk i sykehus (NSAS) har som hovedoppgave å støtte norske sykehus i arbeidet med riktig bruk av antibiotika. Antibiotikasenteret for...

1 of 5 cancer patients needs antibiotics! Nice portal by the Norwegian Cancer Society [Norwegian] kreftforeningen.no/vart-arbeid/...

Dangerous drug-resistant bacteria are spreading in Ukraine - BBC News War appears to have accelerated the spread of pathogens resistant to antibiotics in the country.

www.bbc.com/news/article...

Yeast #proteotoxic stress response: Intrinsically disordered protein Roq1 reprograms specificity of #ubiquitin ligase Ubr1 towards four distinct classes of substrates using its N-terminal arginine linked to a short hydrophobic motif
Sebastian Schuck and colleagues
www.embopress.org/doi/full/10....

How can we develope new antibiotics, and what are the current challenges? Tune in to this podcast to learn more! 🎧 doppelhelix.podigee.io/12-new-episode [German] #AMR #antibiotics #innovation #startup

RHEB neddylation by the UBE2F-SAG axis enhances mTORC1 activity and aggravates liver tumorigenesis
Yongchao Zhao, Yi Sun et al
www.embopress.org/doi/full/10....

The ubiquitin-conjugating enzyme UBE2D maintains a youthful proteome and ensures protein quality control during aging by sustaining proteasome activity Maintenance of proteostasis is key during aging, but the mechanisms underlying this process remain unclear. Here the authors show that the E2 enzyme UBE2D/eff, levels of which decline with skeletal mu...

journals.plos.org/plosbiology/...

Our latest article "Data sharing restrictions are hampering precision health in the EU"
Here is the open acces link:
rdcu.be/d6Bgd
#precisionmedicine 🧬💊🧪

New preprint from the lab exploring global 'acetylome' remodeling during heat shock in yeast, led by Rebecca Hardman-Kavanaugh with strong support by @aaronstorey.bsky.social.

www.biorxiv.org/content/10.1...

Illuminating the impact of N-terminal acetylation: from protein to physiology - Nature Communications N-terminal acetylation is a ubiquitous protein modification in eukaryotes. Here, the authors review the N-terminal acetylation machinery, its impact on protein function and fate, and its role in physi...

www.nature.com/articles/s41...

Looking for fun in a nice place for next summer?
Then, join us at the Yeast 2025 meeting!
Save the date: 21-24 July 2025
Registration and abstract submission are now open!