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⚡ New breakthrough study revealing that a unique #proteotoxic #stress response (Tex​-PSR) is a key mechanistic driver of T cell #exhaustion and #immune evasion in cancer. Targeting this proteostasis pathway represents a promising new approach for enhancing cancer #immunotherapy.

Context is everything! (N-) #degron specificity of a #ubiquitin ligase reprogrammed under #proteotoxic stress. Interesting implications for biology, drug design and how we assess E3 specificity....

Yeast #proteotoxic stress response: Intrinsically disordered protein Roq1 reprograms specificity of #ubiquitin ligase Ubr1 towards four distinct classes of substrates using its N-terminal arginine linked to a short hydrophobic motif
Sebastian Schuck and colleagues
www.embopress.org/doi/full/10....