Structures of the QatBC complex from Angela Gao and Doug Wassarman in our group reveal an evolutionary link between QatABCD and Type IV CBASS and a role for protein deazguanylation in diverse anti-phage defense systems
www.nature.com/articles/s41...
www.science.org/doi/10.1126/...
Excited to share our new findings in @science.org on how the DRT3 bacterial defense system uses a reverse transcriptase that builds DNA repeats without a nucleic acid template. Microbes never cease to amaze!
www.science.org/doi/10.1126/...
Excited to share our new paper out today in @science.org 🎉
We show that HGT via natural competence drives diversification of chromosomal integrons in V. cholerae 🤩
Below a 🧵 on key findings incl. background on natural competence in V. cholerae 1/
#microsky #phagesky
www.science.org/doi/10.1126/...
Excited to share the last installation of my PhD work. Worked with an all-star team on this one who really made this all come together beautifully. @ranidreamer.bsky.social @amardeeep.bsky.social @benadler.bsky.social and many others. www.cell.com/cell-reports...
Postdoc position available in St Andrews for a structural biologist: www.vacancies.st-andrews.ac.uk/Vacancies/W/...
Join us at the LS2 #Theory #across #Biology chalk talk symposium! 12 June 2026 in Bern, CH. @lifesciswitzerland.bsky.social
No movies that fail, no Mac to PC issues. Only the best ideas and exchange across biology from evolution and ecology to physics of life.
meetings.ls2.ch/theory-acros...
Promotional banner for R for Biochemists 201 online training on 18 May 2026 with registration details and Biochemical Society logo.
Starting 18 May, R for Biochemists 201 builds on R101 to advance your skills in proteomic data analysis, tidy data, reproducible workflows & data visualisation. Register now! https://ow.ly/B0uc50YEZ1y
My lab at Pitt is looking for a Research Scientist to help us make phage therapy for patients with antibiotic-resistant infections. Please share and apply! cfopitt.taleo.net/careersectio...
‼️Please share‼️
Nemudryi lab is looking for postdocs to join our team and study:
🦠 Bacterial phage defense mechanisms
🧬 RNA repair & CRISPR-based RNA editing
Excited about RNA, host-virus interactions & mechanistic biology?
Let's talk!
Apply: explore.jobs.ufl.edu/en-us/job/53...
Pls share: A postdoctoral researcher position is available in the Scharf lab in the Department of Biological Sciences at Virginia Tech to study motility and chemotaxis in the symbiotic soil bacterium Sinorhizobium meliloti.
jobs.apply.vt.edu/jobs/postdoc...
The awesome virome logo of a phage above a strand of DNA
Have you developed a new #bioinformatics tool to understand #phage or #virus? Make sure you add it to #awesome-virome
github.com/shandley/awe...
Such an incredible journey building DISCO 🪩. Love working with this team. DISCO is a co-design model with functional, de novo, new-to-nature enzymes. Huge shoutout to my co-authors for making this a reality! 🚀👇
Nucleoid-associated proteins sense phage-induced genome damage to elicit abortive infection www.biorxiv.org/content/10.64898/2026.04...
I2BC is recruiting group leaders in several disciplines.
Don’t miss the chance to launch your team at Paris-Saclay.
Information : www.i2bc.paris-saclay.fr/wp-content/u...
Applications and enquiries : call2026@i2bc.paris-saclay.fr
Deadline: April 22, 2026
Latest from the lab!
Between clinical S. aureus, most gene transfer mechanisms are blocked, yet lateral transduction remains highly efficient.
Restriction modification-defective strains act as gateways for horizontal gene transfer, enabling DNA flow across populations. rdcu.be/fbNQK
Want to annotate a bacterial genome with structures?
@oschwengers.bsky.social bakta and @gbouras13.bsky.social phold got together, and the result is Baktfold: protein annotation across the microbial tree of life using structures
www.biorxiv.org/content/10.6...
#phagesky #microsky #microbiomesky
Repurposing anti-phage defenses to differentially arrest the viral lifecycle reveals the regulatory logic of a parasitic satellite | bioRxiv www.biorxiv.org/content/10.64898/2026.04...
Dissecting the genetic determinants of bacterial DNA degradation by bacteriophage T5 www.biorxiv.org/content/10.64898/2026.04...
Our work on 'hidden diversity' in unbinned contigs is now published in @natmicrobiol.nature.com :
www.nature.com/articles/s41...
See the linked threads for more details!
Phage receptor prediction from genome sequencing alone. Bacterial receptor (blue) interacting with phage proteins (purple) is shown here
📣Huge preprint 🔔
Today we share something our group has been working toward for a long time, led by @lucasmoriniere.bsky.social We asked can we predict which receptor a phage targets from its genome sequence alone? For most phages, we couldn’t. So Lucas set out to do something I had only dreamed of.
Excited to see our work out in Science today! Using machine learning to identify prokaryotic immune systems www.science.org/doi/10.1126/...
There is an image of green, purple, and teal protein spirals on a black background with the announcement of the new RDF3 tutoritals being available. Additional text states “Whether you’re just starting with RFdiffusion3 (RDF3) or looking ot refine your design workflows, these three new tutorials for RFD3 guide you step-by-step through creating new protein structures for your design projects. Learn more at rosettacommons.org/news.” The Rosetta Commons logo is in the upper right corner. The background is a light teal with some hexagons in the corners.
Three RFdiffusion3 (RFD3) tutorials are now available. These tutorials walk you through how to use RFD3 to generate structures for: protein-protein interface design, enzyme design, and nucleic acid binder design, and can be expanded to other areas of interest. Check them out @ zurl.co/og3XK
How diverse is bacterial immunity ?
We report in @science.org how language models allowed us to predict 2.4M antiphage proteins spanning >23K novel potential systems.
👏 @emordret.bsky.social, @alexhv.bsky.social & al doi.org/10.1126/scie...
Explore them here defensefinder.mdmlab.fr/wiki/refseq_...
ROCKET 🚀 inference-time optimization of AlphaFold to fit structural data is published! rdcu.be/fa9YH
Since our preprint, we’ve pushed it to regimes where other methods break: low resolution, weak signal, real experimental edge cases. Here’s what we learned: 1/15
Come join us! We're recruiting 3 new academic posts in the School of Biology, University of Leeds, closing 23/04/26.
Assoc Prof Plant Science tinyurl.com/4x48jc78
Assoc Prof Animal Biology tinyurl.com/2s4sk85s
Lecturer in Ecology, Zoology, Biodiversity or Ecosystem Management: tinyurl.com/39dwp47j
I am excited to share our latest paper, Uniform bacterial genetic diversity along the gut, now out in Nature Communications! www.nature.com/articles/s41.... (1/n)
Tailocins/Pyocins
This paper started as an idea @albertomarina.bsky.social had many years ago… which of course means he was right all along 😄. Some of us just needed a few years (and a lot of experiments) to catch up.
Grateful (and slightly humbled) to be part of this. Thanks Alberto!
www.cell.com/cell/fulltex...
ggCaller v1.5.0 is out! We've removed the integrated clustering to enable users to benefit from new Panaroo features. Now, ggCaller generates GFFs that can be used with any clustering method. But for fans of an integrated ggCaller pangenome workflow read on...
github.com/bacpop/ggCal...
