What will it take to treat patients so that their innate immune systems act like mice & monkeys? Avoid harmful inflammation without being susceptible to infection - a new approach for diseases like #Sepsis & #ARDS. Maybe even chronic inflammatory diseases like #Lupus.
doi.org/10.1186/s100...
/end
The biggest differences were in genes that weren't LPS responsive themselves, but encoded mediators of inflammation, like #TLR pathway proteins.
It will be important to understand how these differences contribute to susceptibility to systemic to inflammation.
6/
Most surprisingly, we could distinguish sensitive from resilient species even without LPS challenge. Baseline gene expression in sensitive animals had a more inflammatory profile.
6/
We didn't find many differences in the #Proteome or #Lipidome than correlated with sensitivity to inflammation.
But #Leukocytes from resilient and sensitive showed clear differences in their responses, including in genes linked to LPS metabolism.
5/
We did a side-by-side comparison of white blood cell gene expression and plasma proteins and lipids in 10 mammals with different reported susceptibility to lethal inflammation. We measured gene expression in naive leukocytes and following ex vivo stimulate with #LPS.
4/
But wait - mice have robust #InnateImmunity. They eliminate bacteria and viruses well and aren't especially prone to cancer; they just don't suffer the bad effects of systemic inflammation.
Whst causes the difference? Can we learn from it to improve treatments for infection and inflammation?
3/
"Mice lie and monkeys don't always tell the truth."
Despite what in vitro experiments predict, different animals have hugely different susceptibility to harmful, systemic inflammation. It takes 100s- or 1000s-fold more bacterial product to cause lethal inflammation in a mouse than in a human.
2/
New study! Learning about #inflammation by studying mammals - a tweetorial.
doi.org/10.1186/s100...
Inflammation helps fight #infection, but if it gets out of control, it can be dangerous for the host.
We like to assume that Inflammation is basically the same for all animals, but ...
1/n
Polio vaccine is the first vaccine that RFK Jr is trying to ban
And so it begins—his war on childhood vaccines is real, extreme, & dangerous
I guess it’s back to iron lungs—that’s what people voted for, right?
www.nytimes.com/2024/12/13/h...
Finding threads like this makes social media worth the effort.
"Countries which implemented NPIs while hospital admissions were low tended to experience lower gross domestic product (GDP) losses in 2020"
Not a very strong effect, however.
There is a human tissue that builds itself up and breaks itself down every 28 days (on average) using non-scarring wound healing and instead of studying that and learning everything we can about it we think it's gross and look for other less relevant models to understand wound healing.
Ruh roh
I guess they worked purely with the receptor and not a virus, so no worry about making a dreaded "gain-of-function" virus, but their finding is concerning.
www.science.org/doi/10.1126/...
Hi Rod, please include me if you are making a 5th pack. Thanks!