now published at BMC Biology!
rdcu.be/fdITD

Congrats to first author @emmajbanks.bsky.social, #ListerFellow @tunglejic.bsky.social and collaborators 👏 Discovered 3-gene control hub and strict regulator genes for gene transfer agent activation and bacterial cell lysis.

Paper in @natmicrobiol.nature.com www.nature.com/articles/s41...

Fast Online 3D SPACE and FLAIR Imaging at 7T Using Multiple Subject‐Specific Parallel Transmission Pulses Based on Subpopulation Universal Pulses Purpose In 3D SPACE and FLAIR sequences, designing single pTx RF pulse for excitation and refocusing pulses by scaling its amplitude can introduce artifacts. This study addresses this by designing m...

Our new paper (with Siemens Healthcare) showing how to rapidly design patient-specific pTx RF pulses to make lower-SAR homogeneous diagnostic-quality 7T SPACE and FLAIR MR images. Special thanks to all my NSERC reviewers who said this wouldn’t work 😉. onlinelibrary.wiley.com/doi/10.1002/...

The supply of blood to brain tissue is thought to depend on the overall neural activity in that tissue, and this dependence is thought to differ across brain regions and across brain states. However, studies supporting these views have measured neural activity as a bulk quantity and related it to blood supply following disparate events in different regions. Here we measure fluctuations in neuronal activity and blood volume across the mouse brain, and find that their relationship is consistent across brain states and brain regions but differs in two opposing brainwide neural populations. Functional ultrasound imaging (fUSI) revealed that whisking, a marker of arousal, is associated with brainwide fluctuations in blood volume. Simultaneous fUSI and Neuropixels recordings showed that neurons that increase activity with whisking have distinct haemodynamic response functions compared with those that decrease activity. Their summed contributions predicted blood volume across states.Brainwide Neuropixels recordings revealed that these opposing populations coexist in the entire brain. Their differing contributions to blood volume largely explain the apparent differences in blood volume fluctuations across regions. The mouse brain thus contains two neural populations with opposite relations to brain state and distinct relationships to blood supply, which together account for brainwide fluctuations in blood volume.

How does blood flow relate to brain activity? We discovered that it reflects two neural populations affected oppositely by arousal. Together, they explain neurovascular coupling in all brain regions and brain states!

Out today in Nature: rdcu.be/fdC2A

@uclbrainscience.bsky.social

Excited to share the latest one from the lab led by José Solano @jolusolo.bsky.social who explored how early life #stress impacts the mouse 🐭 brain 🧠 vasculature
Science 🧪🔬 can be surprising & 2x stress can induce beneficial adaptations leading to resilience, phew!

www.biorxiv.org/content/10.6...

A cellular basis for the mammalian nocturnal-diurnal switch Early mammals were nocturnal while dinosaurs dominated the daytime. Mammalian transition to daytime activity accelerated after the Cretaceous-Paleogene extinction, but the underlying mechanisms remain...

Finally got around to reading this very cool paper on how diurnal mammalian species inverted the response to circadian entraining cues via cell-intrinsic biochemical and molecular mechanisms.
Fun read!
www.science.org/doi/10.1126/...

Regulation of neuronal invasion of small cell lung cancer by STMN2/β-alanine-controlled metabolic reprogramming Zhou et al. demonstrate that perineural invasion (PNI) is an adverse prognostic factor in small cell lung cancer. They identify a neuron-STMN2-β-alanine axis, where the neural microenvironment upregulates STMN2 in tumor cells, reprogramming β-alanine metabolism to enhance cell migration and drive neural invasion, revealing a potential therapeutic target.

Regulation of neuronal invasion of small cell lung cancer by STMN2/β-alanine-controlled metabolic reprogramming

uPA-mediated remodeling of CCL21 gradients regulates lymphatic migration of dendritic cells, by Victor Collado-Diaz, Maria-Nefeli Christakopoulou, Philipp Schineis, @halinlab.bsky.social et al. rupress.org/jcb/article/...

📕 JCB Immune Cell Biology collection 👉 rupress.org/jcb/collecti...

#AAI2026

Peng Chen, Zhenhua Zhu, Baoxing Dong, Junxiang Ji, Yuqing Zhu, Wenqiang Liu, Shou-Dong Ye (Anhui University) and colleagues establish a rosette-forming intermediate stem cell model that captures the peri-implantation transition. rupress.org/jcb/article/...

#CellCycle #CellDivision #StemCells

Fig. 1. Early expression of TgBAC(ankrd1a:EGFP) transgene in the border zone CMs. Hearts of TgBAC(ankrd1a:EGFP);Tg(−0.8myl7:nls-DsRedExpress) (n = 4) were cryoinjured and left to recover for 6 and 15 h. White dashed line outlines the ventricle. Scale bars, 200 μm.

Fig. 6. Persistent TgBAC(ankrd1a:EGFP) expression in CMs adjacent to the residual scar. Hearts (n = 4) of TgBAC(ankrd1a:EGFP);Tg(−0.8myl7:nls-DsRedExpress) zebrafish were cryoinjured and analyzed at 30 dpci, showing different levels of scar resolution (least (A) to most (D) regenerated). The whole hearts after dissection were imaged by fluorescence microscopy (A-D). Serial sections were used for AFOG staining (bright-field images on panels А'-D′) and fluorescence imaging by confocal microscopy (А"-D″). In the indicated region of injury on panels A'-D′, collagen is stained blue, fibrin is stained orange, and CMs are stained brown. Scale bar, 100 μm.

An interesting paper from the Kojic lab shows that ankrd1a - a stress responsive gene is consistently unregulated near damaged site in the ❤️ in zebrafish. Loss of ankrd1a leads to an increase in dedifferentiating cells. Check it out here:
doi.org/10.1016/j.cd...

Vinayagamurthy, Bhatt et al. of the Shantanu Chowdhury lab @csir-igib.bsky.social reveal TRF2 is integral for NSC identity. Surprisingly, non-telomeric function of TRF2, instead of commonly understood telomere protection by TRF2, is critical for NSCs. rupress.org/jcb/article/...

#StemCells

👋Our April issue is out!
Cover: Visualizing #lipids

👉2 Perspectives: #embryo models
👉Comment on #mitochondria DNA
🔬 #telomeres #leukemia #ferroptosis #pyroptosis #PhaseSeparation #CellAdhesion #BreastCancer #lncRNA #metabolism #autophagy #microscopy & more!
www.nature.com/ncb/volumes/...

New @currentbiology.bsky.social paper from Dr. Leila Elabbady on neural circuits that transform a touch stimulus into spatially targeted grooming.

Leila discovered a leg somatotopic map and used it to infer tactile receptive fields in the fly VNC connectome.

authors.elsevier.com/a/1mvu83QW8S...

Changes in antimicrobial resistance profiles of Escherichia coli and the metagenome on Dutch pig farms after antimicrobial usage interventions - npj Antimicrobials and Resistance npj Antimicrobials and Resistance - Changes in antimicrobial resistance profiles of Escherichia coli and the metagenome on Dutch pig farms after antimicrobial usage interventions

Just out in npj Antimicrobials & Resistance @natureportfolio.nature.com

www.nature.com/articles/s44...

We looked at what actually happens to AMR on pig farms when you reduce antimicrobial use through real-world, coaching-based interventions.

Molecular basis for methylation-sensitive editing by Cas9 - Nature ThermoCas9, a genome-editing enzyme that is sensitive to the DNA methylation status of the target locus, is characterized and shows promise for targeting hypomethylated DNA regions in cancer cells.

Nature research paper: Molecular basis for methylation-sensitive editing by Cas9

go.nature.com/4tMQ3XQ

Did you know immune systemB cells are essential for exercise performance?
Learning from B cell deficiency in the mouse model
cell.com/cell/fulltex...

Multi-omic characterization of nasopharyngeal carcinoma delineates the subtype-specific landscape of response to induction chemotherapy - Nature Cancer Li et al. conduct a multi-omics analysis of nasopharyngeal carcinoma and identify three molecular subtypes with distinct immune profiles and responses to induction chemotherapy.

🌟Now in Nature Cancer, multi-omics analysis of nasopharyngeal carcinoma identifies molecular subtypes with distinct immune profiles and responses to induction chemotherapy.

🖊️by Jia-Xing Yue, Na Liu, Aihua Sun, Jun Ma & Fuchu He and colleagues
www.nature.com/articles/s43...

Predictive value of early PSMA upregulation for the response to enzalutamide ± 177Lu-PSMA-617 in poor-risk, metastatic, castration-resistant prostate cancer: substudy of the randomized, phase 2 ENZA-p... Emmett and colleagues evaluate the frequency, magnitude and clinical significance of early prostate-specific membrane antigen (PSMA) upregulation in patients with metastatic castrate-resistant prostat...

🌟New study in Nature Cancer evaluates the clinical significance of early PSMA upregulation in patients with metastatic castrate-resistant prostate cancer treated with enzalutamide with or without 177Lu-PSMA-617.
by @drlouiseemmett.bsky.social & colleagues
www.nature.com/articles/s43...

NF-κB signaling drives rapid skeletal muscle atrophy in patients with breast cancer: The cost of fighting cancer with chemotherapy | American Journal of Physiology-Cell Physiology | American Physiolog... Skeletal muscle wasting is a critical clinical challenge in patients with breast cancer treated with chemotherapy, given its correlation with increased mortality risk and decreased therapeutic efficac...

NF-κB signaling drives rapid skeletal muscle atrophy in patients with breast cancer: The cost of fighting cancer with chemotherapy
journals.physiology.org/doi/abs/10.1...

I am so excited to share our new findings with you! We provide the structural evidence for a direct protein-to-DNA information pathway, showing how a bacterial enzyme 'reads' its own structure to 'write' DNA. www.science.org/doi/10.1126/...

Development of PROTACs for targeted degradation of oncogenic TRK fusions Chromosomal translocations leading to the fusion of tropomyosin receptor kinases (TRKs) with diverse partner proteins have been identified as oncogenic drivers in many adult and pediatric cancers. Whi...

Proud to share our latest paper in @rscchembio.rsc.org, where we tackle oncogenic TRK fusions. Together, @sauravk05.bsky.social and Jiewei Jiang develop potent and selective degraders of the TPM3-TRKA fusion, a key cancer driver. pubs.rsc.org/en/content/a...

We have an exciting new story out at @science.org's Science Immunology! It is all about using #AAV-mediated cytokine delivery to change the lung environment. We can boost #lung #Tregs or delivery anti-inflammatory #cytokines, preventing fatal respiratory collapse

www.science.org/doi/10.1126/...

A series of spontaneously blinking dyes for super-resolution microscopy - Nature Methods A series of spontaneously blinking dyes in the far-red range facilitate single-molecule localization microscopy. These dyes vary in their blinking properties and can be matched to the applications and...

Out in @natmethods.nature.com: More dyes. They work. Quite well. And blink. Pick the one that fits your target, your technique, and your labeling density. With too many collaborators and institutes to list, but anchored at @hhmijanelia.bsky.social www.nature.com/articles/s41...

Kinesin-1 conformational dynamics are controlled by a cargo-sensitive TPR switch Cargo-adaptor binding to the KLC-TPR domains binding triggers structural rearrangements that relieve kinesin-1 autoinhibition, enabling MAP7 recruitment, through an allosteric mechanism that connects ...

Two manuscripts from the lab to catch up upon exploring aspects kinesin-1 regulation. First, our examining the role of cargo-adaptor binding in controlling kinesin-1 conformational dynamics and association with MAP7 is now a VOR @elife.bsky.social elifesciences.org/articles/109...

What does it take to truly understand #cancer in all of its complexity?

Delighted to share our Review in Cell "Cancer ecosystems: A dynamic interplay across scales" with Daniela Quail, where we propose a multi-scale framework connecting tumor ecology with physiology 🧪⚕️

www.cell.com/cell/fulltex...

Phosphorylated tau exhibits antimicrobial activity capable of neutralizing herpes simplex virus 1 infectivity in human neurons Nature Neuroscience - The authors found that the Alzheimer’s disease-associated protein tau, widely considered pathogenic when hyperphosphorylated, has a natural function as part of the...

Phosphorylated tau exhibits antimicrobial activity capable of neutralizing herpes simplex virus 1 infectivity in human neurons

Tau, which is associated with Alzheimer's disease, has functions. It can neutralise virus infections, such as HSV

www.nature.com/artic...
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Toward a fully distributed inhibitory control system: converging evidence across modalities Abstract. Inhibitory control has been associated with the right inferior frontal cortex, supported by converging evidence from lesion, stimulation, and neu

Toward a fully distributed inhibitory control system: converging evidence across modalities academic.oup.com/cercor/artic... Situates large scale cortical interactions during response inhibition in a literature spanning EEG, fMRI & human intracranial electrophysiology -> an emergent system

Great to see this out. Practical guidance on how to use protein depletion systems in C. elegans

Stunning new landmark study from #HHMIInvestigator David Reich & team @harvardmed.bsky.social lets us watch human evolution in real time across 10,000 years, & what ~16,000 ancient genomes reveal is striking: Natural selection didn't stop when civilization began — it sped up: bit.ly/4ep7uJI.