Accelerating Leigh syndrome drug discovery through deep learning screening in brain organoids - Nature Communications Leigh syndrome is a severe, currently untreatable mitochondrial neurological disorder. Menacho, Okawa et al. developed a deep-learning drug screening pipeline in brain organoids, identifying azole com...

www.nature.com/articles/s41...

Check this from @aleprigio.bsky.social

Feels like this paper on protein-templated DNA synthesis by a natural enzyme warrants some comment.
So here's a 🧵. /1
www.science.org/doi/10.1126/...

Varicella zoster virus and the central nervous system Nature Reviews Microbiology, Published online: 24 February 2026; doi:10.1038/s41579-026-01289-9Varicella zoster virus (VZV) infection causes varicella and herpes zoster and, rarely, severe central nervous system (CNS) complications, including encephalitis. Ogunjimi et al. review the evidence linking herpes zoster with stroke and dementia, summarize innate and adaptive immune responses to VZV-related CNS disease, and debate the consequences of vaccination.

ICYMI: New online! Varicella zoster virus and the central nervous system

Today we mourn the passing of our beloved central dogma. It served Crick well. But it is time to let go. www.science.org/doi/10.1126/...

Our latest work on shape-programmable tissues is out in @science.org. By positioning topological defects in cellular nematics, we encode frustrated 2D force fields that relax into predictable 3D shapes. Collaboration with Marino Arroyo’s lab, led by @pauguillamat.bsky.social at @ibecbarcelona.eu.

Spatial, temporal and Notch determination of terminal selector expression controls neuronal cell fate in the Drosophila optic lobe - Nature Neuroscience The authors characterized the spatial origin of Drosophila medulla neurons, completing their previous characterization of the temporal and Notch origins of these neurons and allowing them to correlate...

Félix Simon's paper is out in its final form 😍
When we got into (extreme) detail in the temporal and spatial patterning of neuroblasts, Félix asked a simple question "sure, but how does this translate into neuronal cell fate?". www.nature.com/articles/s41...

Just published in @science.org 🚀

By controlling how cells align, we show that living nematic tissues can be programmed to generate forces and fold into predictable 3D shapes.

A new platform for tissue engineering and the design of smart active materials! 🫆

www.science.org/doi/10.1126/...

Mapping nerves in a whole embryos.

We find that across species and development stages, embryonic nerves display (beautiful) fractal geometry.

More here: www.biorxiv.org/content/10.6...

I really appreciate this discussion! Teaching at all levels needs this discussion right now.

Hi all! 👋
leeboratory.bsky.social and I are recruiting a VIP³ postdoc to join our teams and decode the genetic logic of how blastoids transit to the post-implantation stage. MolBio, genetics and computational approaches. If this sounds like you (or someone you know), we’d love to hear from you! 🚀

🧵New paper from the lab @isd-research.bsky.social @lmu-klinikum.bsky.social @lmu.de in STM @science.org! A human #iPSC-derived #Tauopathy model that endogenously develops late-stage Tau pathology. Free personal PDF: www.science.org/eprint/5H5YD....
Here's what we found👇 1/10

Data. A mouse model of glioblastoma leads to inevitable death within 50 days. Delivery of HSV+TK plus IL2, driven by a strong and specific synthetic superenhancer, allows almost all mice to survive even after nearly 150 days. From Fig5 of Koeber et al 2026

Just look at this graph (Fig 5A,B from Koeber et al).

Amazing.

Congratulations to the Pollard lab and all authors.

www.nature.com/articles/s41...

Saturation editing of RNU4-2 reveals distinct dominant and recessive disorders - Nature Saturation genome editing of RNU4-2 identifies the functional and clinical impact of variants across the entire gene and delineates variants that cause a new recessive neurodevelopmental disorder distinct from ReNU syndrome.

Stunning illustration of how advances in cellular genomics can disentangle links between gene variants & clinical outcomes. Here, saturation editing revealed distinct neurodevelopmental disorders involving the same non-protein-coding gene. 🙌 @nickywhiffin.bsky.social @gregfindlay.bsky.social & co🧬🔬🧪

🚨 Why can’t mammals regenerate limbs like frog tadpoles or salamanders?
In our new paper in @science.org , we show that species-specific oxygen sensing acts as a gatekeeper for initiating limb regeneration 🐭🐸
🔗 www.science.org/doi/10.1126/... #EvoDevo

🚨🚨🚨JOB ALERT🚨🚨🚨

The Image Analysis Unit at Human Technopole in Milan is recruiting for two positions to join our growing team:

1) Bioimage Analyst
2) Research Software Engineer (RSE)

Read on to learn why one of these two people should be you!

Developmental organization of sensory and sympathetic ganglia - Nature Findings suggest that neural crest fate bias predominantly emerges within the neural tube, and that only a minor subset of delaminated progenitors retain multipotency to generate both sensory and sympathetic derivatives.

Nature research paper: Developmental organization of sensory and sympathetic ganglia
go.nature.com/3Qdz2HP

Thrilled that @hansclevers.bsky.social will be our next speaker for the @humantechnopole.bsky.social “HT Seminars: Connecting Discoveries” series tomorrow, April 2nd. A huge thanks to the PhD representatives, Cecilia Reyneri and Sara Buscarini, for hosting!

🚨Job Alert -- again!🚨
You are into disease risk prediction based on images or other data modalities? This is for you! 🫵
careers.humantechnopole.it/job/Postdoc-...
Part of our Scientific AI Flagship @humantechnopole.bsky.social and part of our mission to benefit society via biomedical #AI solutions.

Lysine-11 ubiquitination drives type-I/III interferon induction by cGAS–STING and Toll-like receptors 3 and 4 - Nature Cell Biology Betrancourt, Cinko et al. identify ANKIB1-mediated K11 ubiquitination and OPTN recruitment as a shared mechanism for driving immune signalling by cGAS, TLR3 and TLR4, with functional relevance in inte...

☕Betrancourt, Cinko et al. identify ANKIB1-mediated K11 ubiquitination and OPTN recruitment as a shared mechanism for driving immune signalling by cGAS, TLR3 and TLR4, with functional relevance in interferonopathy and herpes simplex virus-1 protection.
bit.ly/4uRjZnc

🚨 We are hiring! Personally, I think this is a fantastic job, good salary, and fun work place with exceptional colleagues.

⚠️ Warning, I’m quite biased… but still right! 😜

Join us! Apply!!! 🎉

careers.humantechnopole.it/job/AI-Exper...

Role for NF-κB in #herpes #encephalitis pathology in mice genocopying an inborn error of IRF3-IFN immunity. From from Manja Idorn, Søren R. Paludan and colleagues: rupress.org/jem/article/...

📘 In our #InnateImmunity collection: rupress.org/jem/collecti...

#KSInnateImmune26

📢 First preprint from the Casañal Lab!

Excited to share our work on human NSUN2, done together with the brilliant @ecleroy.bsky.social.

Using #CryoEM, we capture the dramatic structural rearrangement of tRNA as it flips a cytidine into the NSUN2 catalytic pocket for m⁵C modification.

Take a look👇

Just two weeks left to apply to the IGNITION PhD Programme! We’re offering fully funded PhD positions.

Join our team @humantechnopole.bsky.social to use cutting-edge human stem cell models to study immune mediated neurodegeneration.

For more info check out: ignition-consortium.eu

Please share 🙏

New preprint by @lancasterlab.bsky.social:
Ventricular Forebrain Organoids Reproduce Macroscale Geometry of the Developing Telencephalon 🧪🧫🧠
www.biorxiv.org/content/10.6...

Serum coating enables feeder-free culture of naive human pluripotent stem cells preserving developmental potential - The EMBO Journal Naive human pluripotent stem cells (hPSCs) represent a pre-implantation epiblast state able to efficiently differentiate into embryonic and extraembryonic pre-implantation lineages and to self-organis...

Eliminating the confounding effects of human pluripotent #stemcell co-culture with MEFs:
@grazianomartello.bsky.social @leeboratory.bsky.social @jzylicz.bsky.social and collaborators describe a serum coating approach for feeder-free culture of naïve hPSCs
link.springer.com/article/10.1...

Learnt from the best here in Milano.

Switch out the Aperol for Campari 🤌

Just two weeks left to apply to the IGNITION PhD Programme! We’re offering fully funded PhD positions.

Join our team @humantechnopole.bsky.social to use cutting-edge human stem cell models to study immune mediated neurodegeneration.

For more info check out: ignition-consortium.eu

Please share 🙏

Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis Gene expression patterns underlie development, but their systematic detection in whole embryos has remained elusive. We introduce a whole-embryo imaging platform using multiplexed error-robust fluores...

Very happy to see this out. 👏 @yinanwan.bsky.social
Bogdan Bintu and team.
Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis | free link Science www.science.org/eprint/5MHTM...

Persistent microglial activation following neonatal CMV infection mediates neurodegeneration www.science.org/doi/10.1126/...