Wonderful work, David! The concept that ETC flux—not ATP—licenses cDC1 immunogenicity through /metabolite control of DNA methylation is conceptually beautiful. Congrats to Ignacio, Stefanie and the whole team! Thanks for giving us the chance to learn throught this collaboration!

Happy Year of the Horse!

Do not miss this opportunity to join our team!
careers.carrerasresearch.org/jobs/6888353...

🔬IMMERGE News!

Our Gene Editing Technologies & Innovation, transfer, and Entrepreneurship workshops kicked off this morning at Ospedale San Raffalle in Milan!

A huge thank you to @dimiccolab.bsky.social and Anastasia Conti for the warm welcome and support in hosting us!💡🧬

👏 Proud moment for #IMMERGE! Our DC7 fellow Hanna Norbäck co-chaired a session at the 2025 DBM Summer Symposium (@unibas.ch) together with Dr. Zaugg. 🌟
A great day of science, collaboration & inspiring talks! 🧪🔬

#DBMSymposium2025 #TeamDBM #AcademicLife #Science #IMMERGE

🌟 #IMMERGE 2025 PI spotlight: Prof. Warnatz on immunodeficiencies!

Exploring T & B cell changes, unique glycosylation, & risk factors for premature mortality:

1️⃣ pubmed.ncbi.nlm.nih.gov/40496855/
2️⃣ pubmed.ncbi.nlm.nih.gov/40090481/
3️⃣ pubmed.ncbi.nlm.nih.gov/40013136/

More highlights coming soon!🚀

We’re thrilled to have contributed to this outstanding work led by @jlsardinalab.bsky.social & Gemma Valcárcel! 🧬💡

This study is a milestone in showing that epigenetic editing can causally shape immune identity and inflammatory responses.

@carrerasijc.bsky.social
#Epigenetics #CRISPR #Immunology

Single-cell ultra-high-throughput multiplexed chromatin and RNA profiling reveals gene regulatory dynamics - Nature Methods This work presents SUM-seq, an ultra-high-throughput method for co-profiling chromatin accessibility and gene expression in single nuclei across multiplexed samples, advancing the study of gene regula...

🧬 New in Nature Methods!

Congrats to IMMERGE PI Judith Zaugg and team on SUM-seq—a new ultra-high-throughput multiplexed sequencing for profiling chromatin accessibility & gene expression in single nuclei. Tested in macrophages, T cells & iPSCs!

📖 Find out more: tinylink.net/a3PNE
#IMMERGE #MSCA

🚀The IMMERGE consortium met in Heidelberg for our 2nd training event & Midterm Review!

DCs joined sessions on:
🔬Epigenetic & Transcriptional Regulation
🧠Leadership & Management

Huge thanks to all involved—and to @embl.org for hosting us!

🌍Next stop: Milan!
👉 immergeproject.eu

#IMMERGE #MSCA

Busy and inspiring week at @embl.org for the @immerge.bsky.social midterm review and two great workshops: #Epigenetics & #TranscriptionalRegulation, and #Leadership & #Management. Grateful for the science, the insights, and everyone’s commitment !

Huge congratulations to Anna Ferreté-Bonastre on a fantastic PhD thesis defense! Excited to see where your science takes you next! #PhDDefense #Epigenetics #Monocytes subsets #AutoimmuneDisease

Huge thanks to all who contributed: @elimereu.bsky.social at @CarrerasIJC.bsky.social, Paulo Pinho e Costa and Bárbara Leal at @ICBAS_UPorto, and @LagunaAriadna at @VHIR_! & more!

The HuMicA and the code used to generate it is available at in7yqx-ricardo-ferreira.shinyapps.io/shinyapp/ and github.com/RicardoMarti...

The integrated single-cell RNA-seq object included 90,716 CNS myeloid cells, mostly microglia, 241 individual samples & 19 input datasets. We describe nine transcriptionally distinct subpopulations, one of which “Lipo.DAM” is expanded in #Alzheimer’s disease and #MultipleSclerosis

The Human Microglia Atlas (HuMicA) unravels changes in disease-associated microglia subsets across neurodegenerative conditions - Nature Communications The Human Microglia Atlas includes 91,716 brain immune cells covering six neurologic pathologies. It characterizes the signatures of nine populations and describes the expansion of GPNMB-high microgli...

🚨 New paper alert 🚨 Our Human Microglia Atlas (HuMicA) characterizes #microglia subpopulations across 6 distinct #neurologic diseases. www.nature.com/articles/s41...

Never too late to celebrate a #NewYear with the team #epigenetics & #immunology

Spatial transcriptomic clocks reveal cell proximity effects in brain ageing Nature - A spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T...

Thrilled to see this paper out!! 🧪

Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors!

Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social!

rdcu.be/d33uQ 🧵

An ultra-early, transient interferon-associated innate immune response associates with protection from SARS-CoV-2 infection despite exposure Our interferon-associated signature of early SARS-CoV-2 infection characterises a subgroup of exposed, uninfected contacts in three independent cohorts who may have successfully aborted infection prior to induction of adaptive immunity. The earlier transient upregulation of signature genes in PCR-negative compared to PCR-positive CHIM volunteers suggests that ultra-early interferon-associated innate immune responses correlate with, and may contribute to, protection against SARS-CoV-2 infection.

Why do some people, despite SARS-CoV-2 exposure, not develop an infection?
An ultra-early interferon response blocks Covid
www.thelancet.com/journals/ebi...
adds to protection from pre-existing, cross-reactive T cells in some people

IFNg stimulation induces SLAMF7 expression on myeloid cells in rheumatoid arthritis. SLAMF7 engagement (with recombinant SLAMF7) then leads to a strong increase in a large number of proinflammatory mediators. SLAMF7+ are found in a number of inflammatory conditions.
1/

In close collaboration with Roser Vento-Tormo & Klaus Warnatz ‘s teams & the support of @CaixaResearch

#COVID19 research #immunodeficiency

🚨 New paper alert 🚨 How do primary immunodeficient patients respond to SARS-CoV-2 🦠 infections? Find out what single-cell omic & spectral cytometry revealed in our latest #NatCommun article
www.nature.com/articles/s41...

😱

Please help us find a candidate! Just one week left! #postdoc position

Interleukin-1α release during necrotic-like cell death generates myeloid-driven immunosuppression that restricts anti-tumor immunity Hänggi et al. investigate how tumor necroptosis regulates anti-tumor immunity and find an unexpected role for interleukin-1α (IL-1α) release by dying cells in promoting tumor growth by driving recruit...

IL-1 is SO RELEVANT in cancer 🔥 IL-1a released from dying tumor cells leads to myeloid cell recruitment and T cell suppression - targeting this pathway boosts efficacy of chemoTx and ICB

Beautiful study by @ruffell-lab.bsky.social lab n Cancer Cell

www.cell.com/cancer-cell/...

x.com/eballestar/s...

🎉 Delighted to announce that our #EPPerMEd Joint Transnational Call 2024 #PROMISE project has been awarded. Joining forces with Grimbacher, Bock, Moschese, VanNieuwenhohe & Schulze ! Mining #InbornErrorsofImmunity for Personalized Therapeutic Strategies in Non-monogenic Inflammatory Disorders

🚨 #Postdoc position 🚨

Join our lab at the #IJC in #Barcelona to lead innovative #Epigenetics & #SingleCell #Omics research on
#SecondaryImmunodeficiency in #Leukemia patients, funded by #Grifols.

institut-josep-carreras-ijc.jobs.personio.com/job/1760907?...

Do not miss the chance to make a difference as #ProjectManager of the #IMMERGE #DoctoralNetwork

institut-josep-carreras-ijc.jobs.personio.com/job/1796149?...