Ependymoma group-specific blood-brain barrier differences uncovered by a multi-omics approach - Scientific Reports A significant obstacle in treating brain tumors is the limited drug penetration across the blood-brain barrier (BBB), characterized by an interplay of endothelial tight junctions and efflux pumps. Bra...

Thrilled to share our latest work on the blood–brain barrier in ependymoma!
Our data suggest the BBB remains largely intact — challenging assumptions about drug access.
Read more: www.nature.com/articles/s41...
#Ependymoma #BBB #BrainTumors

@dkfz.bsky.social @stjuderesearch.bsky.social @doctorpauln77.bsky.social @meduniwien.ac.at

M-PACT leverages cell-free DNA methylomes to achieve robust classification of pediatric brain tumors - Nature Cancer Smith et al. present M-PACT, a deep neural network leveraging low-input cell-free DNA methylation profiles to achieve robust classification of pediatric brain tumors and enable cellular deconvolution ...

Excited to share our latest work—establishing a pipeline for DNA methylation–based CNS tumor diagnostics from minimally invasive CSF liquid biopsies—published today in Nature Cancer! Huge thanks to all collaborators. www.nature.com/articles/s43... #LiquidBiopsy #PediatricNeuroOncology #TeamScience

#teamkitzheidelberg ran for connor! www.connorsrun.com/fundraisers/... #connorsrun #braintumorcharity #honortoconnor

Connor's Run 2025 - All of September Your support means we can continue to fund critical research projects, improved testing, in-home care and clinical trials, to help change the odds for kids with brain cancer.

Support Connor's Run and #teamkitzheidelberg to raise awareness for childhood brain cancers, especially Ependymoma! www.connorsrun.com/fundraisers/... #connorsrun #braintumorcharity #honortoconnor

Ultra-low-input cell-free DNA sequencing for tumor detection and characterization in a real-world pediatric brain tumor cohort - Acta Neuropathologica Communications Molecular profiling of pediatric central nervous system (CNS) tumors has important clinical utility for guiding diagnostic and therapeutic strategies. Cell-free DNA (cfDNA) from liquid biopsies has be...

We are excited to share our latest work highlighting the potential of liquid biopsies for pediatric CNS tumor patients - just published in Acta Neuropathologica Communications! Thank you to everyone who contributed to this study! doi.org/10.1186/s404... #LiquidBiopsy #cfDNA #PediatricNeuroOncology

We had the privilege of presenting at this year’s Pediatric Neuro-Oncology Conference in San Diego. It was great to share our research and connect with friends and future collaborators dedicated to improving outcomes for children with brain tumors. #PediatricNeuroOncology #TeamScience #SNOPeds2025

Thanks to all partners from @sickkidsto.bsky.social , @themaximacenter.bsky.social , @cruk-ci.bsky.social , @crhorizons.bsky.social , @umcutrecht.bsky.social , and @oncodeinstitute.bsky.social for making it possible!

Thanks to the #Eureka Institute and @sickkidsto.bsky.social for hosting an amazing Translational Medicine Course and turning Tom Fischer and Leonhard Bamberg into newly baked #Eurekans! Loved it in Toronto!

Experimental Insights and Recommendations for Successfully Performing Cerebral Microdialysis With Hydrophobic Drug Candidates Cerebral microdialysis in rodents represents a robust and versatile technique for quantifying the pharmacologically relevant unbound fraction of drugs in the brain. When this unbound fraction is simu...

Paper on the challenges of hydrophobic drugs in cerebral microdialysis accepted to #CTSJournal, #ASCPTJournalFamily Based on own data + intensive literature review, we developed a decision tree to guide future studies in testing unspecific binding prior to microdialysis: doi.org/10.1111/cts....