Congratulations Jakub!! 👏🏽👏🏽👏🏽👏🏽

Congratulations to @jakubegan.bsky.social, @brozlab.bsky.social et al. A nice reminder that lipid acyl chains are not just defining binding interactions. They tune membrane curvature and flexibility, adding an additional layer of regulation to protein activity and cellular signalling

Congratulations 🎉👏🏽 Glad to see this out and read the whole story!

Ha finalizado el segundo día de Café Con Ciencia en el IPBLN, nos han visitado los institutos: IES Veleta, Instituto Diego de Siloé, IES Virgen de la Caridad, IES Emilio Muñoz e IES Virgen de las Nieves.

¡Esperamos haber despertado en vosotros nuevas vocaciones científicas!

@csic.es

Enteropathogenic bacteria evade ROCK-driven epithelial cell extrusion - Nature The bacterial ubiquitin ligase NleL evades host defence mechanisms both by inhibiting pyroptosis and by preventing infected intestinal epithelial cells from being extruded into the lumen and expelled ...

Check out our new publication, a collaboration with Giovanni Luchetti and Vishva Dixit @ Genentech.
We show that the E.coli effector NleL inhibits intestinal epithelial cell extrusion after #inflammasome activation via degrading the kinases ROCK1 and 2!!
www.nature.com/articles/s41...

Explainer 1/8

#InflammaZoom free Webinar is back on Monday October 20th! With James Murphy (WEHI, Melbourne, Australia) @pseudokinase.bsky.social and Jonathan Maelfait (VIB-UGent, Ghent, Belgium)

Register now: bit.ly/4iXGqjw

📌 Save the Date - #EUResearchersNight returns on Friday 26/09!

Join us across Europe for a night full of science, discovery & fun - connecting curious minds with brilliant researchers, including ERC grantees and their teams💡!

📍Find events near you: link.europa.eu/TbHmPP 🧪

Thank you! I had a great time

Thank you for having me !!!

Very cool talk today at #CABDseminars by Malvina Pizzuto. Dr. Pizzuto explained the work assessing cardiolipin control over inflammatory pathways and immune dysfunctions. Malvina was invited by Peter Askjaer. Thanks for coming @malvinapiz.bsky.social

✅Ha venido la doctora Malvina Pizzuto, a hablarnos de "Evaluación del control de la cardiolipina sobre las vías inflamatorias en situaciones de enfermedad como el shock séptico". 🦠
@ipblncsic.bsky.social
@csic.es
@csicandalextrem.bsky.social
@universitypress.cambridge.org
@malvinapiz.bsky.social

#CABDseminars

"Assessing Cardiolipin Control Over Inflammatory Pathways and Immune Dysfunctions" by Malvina Pizzuto @malvinapiz.bsky.social, University of Cambridge (UK)

🗓️ September 19 th
⏰ 12 pm
📍Rosalind Franklin Auditorium at the CABD

Hosted by Peter Askjaer

Cardiolipin inhibits the non-canonical inflammasome by preventing LPS binding to caspase-4/11 | The EMBO Journal imageimageAvailable caspase-4/11 (CASP4/11) inhibitors also block the activity of caspase-1 (CASP1), which complicates interpretation of results in functional studies and limits their clinical potenti...

www.embopress.org/doi/full/10....

Still wrapping my head around the fact that it’s finally out!! 🎉 From hypothesis in 2017 to data in 2020, it took 5 more years to fully prove the story. Long road for a lipid inhibitor, but worth it. Wonder how long a Nature paper takes… maybe I’ll find out soon! 😉 #ResearchLife

🚨It’s out @embojournal.org 🚨
Cardiolipin inhibits Caspase-4/11!
Huge thanks to my brilliant supervisors Kate & Pablo, to @s-burgener.bsky.social & Mercedes and all the @inflammasomelab.bsky.social, it was a joy working and laughing with you, and to @brozlab.bsky.social & Si Ming lab.

La battaglia dei ricercatori italiani finisce a Bruxelles. L'esposto alla Commissione Ue contro i nuovi contratti: «Viola gli impegni Pnrr» Raffaele Vitolo (Adi) spiega a Open perché i dottorandi considerano «incompatibile» con le direttive Ue l’emendamento Occhiuto alla legge Pnrr, che introduce due nuovi contratti

www.open.online/2025/06/06/d...

#celldeathresearch #careerdevelopment | Australasian Cell Death Society (ACDS) 🥇2025 ACDS Professional Development Award 🥇 Applications are now open! Are you a PhD student or early-career researcher in the cell death field? Don’t miss your chance to apply for our $2,000 travel ...

(1/3) 🏆 Applications are now open for the 2025 ACDS Professional Development Award!

A $2,000 grant for a PhD student or ECR to support national or international professional development 🌍✈️
Conference? Lab visit? Data training? This one's for you.

More info below

Streaming tomorrow morning in Europe! Don't miss it

The last three weeks before leaving my current lab 😅 you are never done with experiments!

My 1st post in bluesky goes for🚨phagocyte lovers🚨

send ABSTRACT & REGISTER NOW!!!
phagocytes2025.com
📌Madrid @CNIC_CARDIO
📆 26-28 March '25
20 🔝🌍speakers
28 short talks + posters

Support by
www.inmunologia.org
www.embo.org
CRC_TRR332 & TRR359_PILOT
Travel bursaries by www.efis.org & EurJImmunol

Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells - Nature Immunology Pyroptotic cell death results in inflammation. Here the authors find that F-actin-rich structures formed during macrophage pyroptosis persist after cell death to activate dendritic cells.

#NoTimeToDie! @inflammasomelab, Holley, Monteleone &co show @natimmunol.bsky.social that cells that die by #pyroptosis, or #necroptosis, are crowned with F-actin filopodia that makes them visible by dendritic cells via CLEC9A to initiate adaptive immunity! www.nature.com/articles/s41...

Imagine cells bursting into tiny fireworks to alert the immune system and spark a powerful defense.

@carolinelholley.bsky.social @inflammasomelab.bsky.social @jkagan.bsky.social @samstehbens.bsky.social
@doktrnick.bsky.social

t.co/dE9wPARavh
#ImmunoSky 🧪

Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release ACE2 in macrophages promotes infection that enables an intrinsic antiviral response to SARS-CoV-2.

How do macrophages sense SARS-CoV-2 infection to drive inflammation (protective or disease causing) in COVID-19? Our 2023 paper in Science Signalling helps explain 🧵
www.science.org/doi/10.1126/...

Grateful to be part of the amazing team behind our student and postdoc associations @SIMBAatUQ @EMCRA_IMB @IMBatUQ. We've worked hard to support our community. I'm also honored to receive recognition for my contribution. Still so much to do, best of luck to next year’s committees

Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells Nature Immunology - Pyroptotic cell death results in inflammation. Here the authors find that F-actin-rich structures formed during macrophage pyroptosis persist after cell death to activate...

Have you ever wondered whether pyroptotic corpses have functions beyond the grave? We made the surprising discovery that pyroptotic corpses are flagged by #filopodia to alert #DendriticCells they need autopsy. A short Bluetorial (1/13)👇with movies!
Link: rdcu.be/d2mjm

Hi all! My name is Cornelius, and I'm an assistant professor in the Department of Biochemistry and Biophysics @pennmedicine.bsky.social @upenn.bsky.social. My lab is interested in host-pathogen interactions with a focus on how the host responds to infections. I'm passionate about mentoring, too!

Hi all, my name is Malvina. I am a senior postdoctoral researcher trying my best to start my lab and study the regulation of the immune system by cardiolipin and mitochondria. I am passionate about #inflammasome #caspases and #mitochondria, and I advocate #equity #diversity and #inclusion in science

Hi Natalia, can you add me as well, please?