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www.npic.orst.edu/factsheets/c...

‘These effects can last for days or even weeks. During this time, the body is replacing the depleted enzymes in the nervous system so it can function normally again.’

‘The studies showed that
-chlorpyrifos-
disrupts autophagy,
the cellular system responsible for clearing damaged proteins from cells.
When researchers restored this cleanup process or removed synuclein protein, the neurons were protected from injury.’

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MECFS | LONG COVID

‘A decrease in the relative abundance of the Lachnospiraceae family, genus Faecalibacterium and Roseburia, and species of Faecalibacterium prausnitzii and Odoribacter splanchnicus, as well as an increase in Eggerthella spp., was revealed in chronic pain patients compared to controls.’

"Education is critical"
says the Minister for Skills & Training in the Albanese ministry, @andrewgilesmp.bsky.social - as said Albanese Ministry denies funding for public education while pouring it into the private schools.

So, when Andrew says 'education is critical', he only means for some kids.

Cases of invasive meningococcal disease have been confirmed in Kent. It's important to know the signs of symptoms of meningitis and septicaemia. Get more info from @NHSuk
nhs.uk/conditions/m...

Meningococcus is transmitted by aerosol or direct contact with respiratory secretions of patients or healthy human carriers. As a rule, endemic disease occurs primarily in children and adolescents, with highest attack rates in infants aged 3-12 months, whereas in epidemics older children and young adults may be more involved. Nasopharyngeal carriage of meningococci is most common among adolescents and young adults, less so among young children and relatively rare in adult populations. Transient nasopharyngeal carriage rather than disease is the normal outcome of meningococcal colonization.

WHO says meningococcal disease is airborne.

It's pretty clear now that all droplets are generated with aerosols, and everything we mistook as physics-defying droplet transmission is actually aerosol transmission.

#MaskUp #CleanTheAir

www.who.int/teams/health...

🤨
bsky.app/profile/cast...

Persistent Gut-Immune Axis dysregulation in long-term Post-COVID Syndrome: Insights from a prospective, observational, cross-sectional case-control study — Augustin et al "we observed persistent viral proteins in the terminal ileum" "increased local mast cell activation, elevated zonulin levels, and an expansion of pDCs and NK cells CD56dim in the terminal ileum support a role for the gut-immune interface in PCS pathogenesis."

From Germany & Austria

Persistent Gut-Immune Axis dysregulation in long-term Post-COVID Syndrome: Insights from a prospective, observational, cross-sectional case-control study

www.sciencedirect.com/science/arti...

Screenshot from latest Science for ME weekly update

#LongCovid #PASC

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Tweet from Acyn reporting CNN breaking news that Cuba’s electrical grid has completely collapsed, causing a nationwide blackout. The image shows a dim city skyline at dusk with a domed building silhouetted, alongside a CNN banner reading “Cuba’s electrical grid suffers total collapse.”

There are some 3,000 patients on dialysis machines in Cuba who are at risk of dying from a prolonged blackout.

Symptom Spotlight Post-exertional malaise: not just tired https://mecfssa.org.au/resources/post-exertional-malaise-pem • Key Symptom of ME/CFS: Post-Exertional Malaise • Post-exertional malaise (PEM) or post-exertional neuroimmune exhaustion (PENE) is a pathological loss of energy and worsening of symptoms following minimal physical, mental or emotional effort, or other triggers. The onset of PEM may be immediate or delayed by several hours or days. Recovery is prolonged and may take days, weeks or months. • When people with ME/CFS push themselves to use more than their available energy reserves, the loss in functional capacity is inevitable and cannot be reversed by a long rest or a good night's sleep. People often struggle to describe this loss of energy, weakness and exacerbation of symptoms. They may use words like crash, payback, debilitating exhaustion. Drawing of someone looking exhausted and distressed holding tightly to their blanket

This image from ME/CFS South Australia refers to this useful webpage on Post-Exertional Malaise (PEM) on the ME/CFS Australia site:
mecfs.org.au/resources/po...
(the URL redirects here)

#MEcfs #PEM #PostExertionalMalaise #CFS #PwME #MyalgicEncephalomyelitis #ChronicFatigueSyndrome

Year-end surge: electric trucks outsell diesel for the first time in China - electrive.com In December 2025, 45,300 fully and partially electrified heavy-duty trucks were newly registered in China—accounting for 54 percent of total heavy-duty truck

EV trucks are taking over in China

Can't wait to be rid of the noise and smell of diesel trucks

www.electrive.com/2026/01/23/y...

Large-scale metaproteomics of human gut #microbiota reveals microbial functions in metabolic diseases & #aging.

Analysis of 1,967 gut samples links microbial function to aging, metabolic disease, drugs, showing M. elsdenii as key diabetes‑related species.

www.sciencedirect.com/science/arti...

#Medsky🧪 #IDsky #immunosky #neurosky #publichealth Role of inflammatory cytokines in mental disorders
Across the multiple evidences & studies , inflammatory cytokines consistently emerge as mechanistic biomarkers linking #COVID infection to neuropsychiatric symptoms,

Neurology: Incidence of Childhood Stroke and Association With Recent Infection: A Population-Based Study Using Linked Data

Lachlan L Dalli et al

bit.ly/4cGPsSs

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• #Circadian disruption causes #immunity risks
• Clock genes are potential targets for treating #autoimmune diseases.
www.sciencedirect.com/science/arti...

Meal timing represents a modifiable factor influencing metabolic health and possibly early carcinogenesis. Aligning eating behavior with intrinsic #circadian rhythms may help mitigate #cancer risk and improve long-term well-being.
www.sciencedirect.com/science/arti...

Real leaders protect the most vulnerable.
Real leaders recognize the fragility of life.
Real leaders preserve the environment for future generations.
Real leaders negotiate treaties.

Thank you! 🌱

They found differences between disease groups.

ME/CFS antibody complexes were linked to proteins related to extracellular matrix structure.

These proteins are involved in tissue and blood vessel structure.

Figure 6. Personalized treatments outperform standard of care. For both SCFAs, an optimal prebiotic and/or probiotic treatment combination was selected and compared against a standard treatment, which consisted of inulin and the 5-strain probiotic cocktail. In both cases, the individual-specific optimal treatment showed significantly higher levels of production. Significance determined by Mann-Whitney U-test, *** = p<0.001.

The original synbiotic contained inulin. If we set inulin as the 'standard' intervention, we find that a individually-tailored prebiotic intervention almost always performs better than the standard, in terms of SCFA production.

Short Chain Fatty Acids enhance intestinal barrier function, lower endogenous inflammatory factor levels & thereby reduce..incidence of arthritis.In RA models, SCFA supplementation significantly ameliorates pathological joint changes, reduces joint swelling & pain, & restores joint immune balance..’

Microbial SCFAs as #epigenetic mediators: fine-tuning the gut-brain axis in neurodegenerative disorders.

SCFAs from gut microbes modulate brain epigenetics, offering neuroprotective effects & therapeutic potential for NDs
www.sciencedirect.com/science/arti... #OpenAccess #microbiota #SCFA #MicroSky

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Abstract Background: In the context of long COVID, persistent fatigue is among the most prevalent symptoms that can develop after SARS-CoV-2 infection. Mitochondrial myopathy and endothelial dysfunction, which are triggers of inflammation, have emerged as prominent causes of long COVID-induced fatigue. Interestingly, the intake of flavanols, particularly (−)-epicatechin (EC), has been associated with the positive modulation of endothelial and mitochondrial structure and function. Methods: In this work, we conducted a randomized, double-blind, placebo-controlled clinical trial to determine whether an EC-enriched supplement (ECES) improves plasma markers of inflammation, endothelial structure, and fatigue-related endpoints in patients with long COVID-19. Results: The study included 46 subjects (mean age 52 years) who were instructed to consume two capsules/day for 90 days of either ECES (n = 23) or placebo (n = 23). Endpoints assessed included mean changes in plasma inflammatory markers (IL-1β, IL-6, and TNF-α) and endothelial dysfunction markers (syndecan-1), handgrip strength, fatigue scale, and quality of life (QoL). The results showed significant improvements in the ECES group for inflammatory markers, syndecan-1, and fatigue compared with the placebo group. Conclusions: The results yield intriguing positive findings for EC and open a new avenue for treating long COVID.

From Mexico:

Effects of Cacao Flavonoids in Long COVID-19 Patients with Chronic Fatigue: FLALOC, a Placebo-Controlled Randomized Clinical Trial
www.mdpi.com/2077-0383/15...

One discussion here:
www.mdpi.com/2077-0383/15...

#LongCovid #ChronicFatigue