Diagnosis and Management of Candida Endophthalmitis and Chorioretinitis Candida endophthalmitis and chorioretinitis are uncommon but potentially devastating complications of candidemia, associated with significant risks of vision loss and long-term morbidity. Effective ma...

Diagnosis and Management of Candida Endophthalmitis and Chorioretinitis

Nate Permpalung, Sarah Sedik, Pete Pappas, @martinhoenigl.bsky.social, @drluiso.bsky.social in @cmijournal.bsky.social

www.clinicalmicrobiologyandinfection.com/article/S119...

Histoplasma antigen screening in advanced HIV disease Ilan S Schwartz, Alessandro C Pasqualotto; Histoplasma antigen screening in advanced HIV disease, Clinical Infectious Diseases, , ciaf238, https://doi.org/

Histoplasmosis remains an important cause of AIDS-related deaths in many regions

Histoplasma antigen tests are now cheap, accessible, and can be done at POC

Are such assays ready to be used for routine screening of patients with advanced HIV?

We have thoughts 🤔

🔓 academic.oup.com/cid/advance-...

Th1 differentiation and function are inhibited in neonates following human metapneumovirus infection
academic.oup.com/jimmunol/adv...
@jimmunol.bsky.social

Neonatal antibiotics impair infant vaccine responses - Nature Reviews Immunology A prospective observational study of human immune responses to vaccination after early-life antibiotic exposure shows that neonatal exposure reduces the immune response to several vaccine antigens and...

NEW Highlight of @nature.com paper by @davidjlynn.bsky.social and colleagues @sahmri.bsky.social reporting a prospective observational study of human immune responses to #vaccination after early-life #antibiotic exposure.
#immunology #immunosky #medsky #IDsky #pedsky #publichealth

Liver X receptor unlinks intestinal regeneration and tumorigenesis - Nature Liver X receptor drives epithelial Areg-mediated intestinal regeneration, while preventing tumour growth through adaptive immune responses.

I go around saying that tissue repair and tumorigenesis are two faces of the same coin. @ejvillablanca.bsky.social &co now show that this is not always the case and the two processes can be "unlinked" in the gut! @natureportfolio.bsky.social

www.nature.com/articles/s41...

Performance of 2 Finger-Stick Blood Tests to Triage Adults With Symptoms of Pulmonary Tuberculosis: A Prospective Multisite Diagnostic Accuracy Study Two finger-stick blood tests to triage people with symptoms of pulmonary tuberculosis by measuring 3 host proteins (multibiomarker test) or 3 host RNA tran

Non-sputum, blood fingerprick triage diagnostic tests for pulmonary TB!

Nice work @jaynesutherlandtb.bsky.social. As you state there are still groups to verify this, but looks promising. Look forward to reading in detail.

#IDSky #TBSky
@cidjournal.bsky.social
academic.oup.com/cid/advance-...

Integrated liver-secreted and plasma proteomics identify a predictive model that stratifies MASH
@cp-cellrepmed.bsky.social
www.cell.com/cell-reports...

Multi-zonal liver organoids from human pluripotent stem cells @nature.com @cincyresearch.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...

Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections | NEJM Bloodstream infections are associated with substantial morbidity and mortality. Early, appropriate antibiotic therapy is important, but the duration of treatment is uncertain. In a multicenter, non...

The 14 day paradigm for antibiotics first bloodstream infection is long since dead.

The BALANCE trial is another nail in its coffin

#IDSky

www.nejm.org/doi/full/10....

Tongue 👅 lesion/oedema
Cancer ?
Biopsy said otherwise…
#IDsky

<em>Immunology & Cell Biology</em> | ASI Journal | Wiley Online Library In this manuscript for the “Highlights of 2024” series, this is me trying to summarize recent discoveries regarding the emerging regulatory and effector roles of γδ T cells during sepsis, both in hum....

Are you ready for it?

"Highlights of 2024: γδ T cells and bad blood"

A summary of the emerging regulatory and effector roles of #gdTcells in #sepsis.

And it may also contain a few Taylor Swift references. More than 50 in fact.

Thank you so much @immunolcellbiol.bsky.social for playing along!

Macrocycle-based PROTACs selectively degrade cyclophilin A and inhibit HIV-1 and HCV - Nature Communications Targeted protein degradation has so far been rarely applied as an antiviral strategy. Here, the authors report that macrocycle-based PROTACs targeting host protein cyclophilin A, exploited during vira...

Happy to announce that our 2nd paper of 2025 is out! 🎊

This collaboration between our brilliant postdoc @lsnewton.bsky.social and @claragathmann.bsky.social, from Dave Selwood’s chemistry lab, designs and employs PROTACs to degrade CypA and inhibit HIV and HCV.

www.nature.com/articles/s41...

This reminds me of some people who put milk first and then cereal 🤣

A multi-omics spatial framework for host-microbiome dissection within the intestinal tissue microenvironment
www.nature.com/articles/s41...
@garrypnolan.bsky.social
@naturecomms.bsky.social

Recirculating regulatory T cells mediate thymic regeneration through amphiregulin following damage
www.cell.com/immunity/ful...
@cp-immunity.bsky.social

UKHSA launches new metagenomic surveillance for health security The UK launches mSCAPE, a world-first metagenomics initiative by UKHSA to enhance health security through rapid pathogen detection and surveillance.

Our mSCAPE project has been formally announced to the world by @smhopkins.bsky.social at #FOG2025 today: www.gov.uk/government/n... - a really exciting academic-public health collaboration to build a surveillance platform leveraging NHS metagenomic diagnostic data. @meerac.bsky.social

Well done @drakishl.bsky.social ... A lot of work to do the meta-analysis!

ONE ANTIBIOTIC PK TABLE TO RULE THEM ALL

Absorption takes drug into blood from GI,
Vd spreads drug out to where bug calls home.
And after bacteria are doomed to die,
The drug’s eliminated on the porcelain throne

In the Land of Notion where this table doth lie…

#idSky #microsky #pharmsky #medsky

😂

Thanks for highlighting!

agree! I need to detox actually, maybe phone intermittent fasting? 12-8 only (except on calls). I can feel the withdrawal effects already..

parents --> rearranging childcare and work to stay by bedside 'in case infection' to complete Abx and society, NHS cost, burden of AMR.

Lastly, many say, does it matter? Antibiotics are cheap and well tolerated? Think issue is for baby, Family and society. Baby- dysbiosis --> higher chance NEC, more sepsis, longer in hospital..

Our approach is host immune profiling with paired metagenomics with colleagues at Royal London - will report back!

..we know you can get local infection without bacteremia and not all organisms can be cultured in the first space! Think solution is innovation of better rule out tests at 24-36 hours to assist decisions on de-escalation, ie more objectivity.

trends in CRP and how baby doing....but still we often continue for a minimum of five days- why? Because it's nuanced- neonatologists worry about culture sensitivity given low blood volumes from neonates and possiblity false negatives (in theory),

Any stewardship here would require new very very good point of care tests, and even then, may not be sufficient to exceed threshold of clinician gut instinct. For stewardship, 24-36 hours seems sweet spot when you have had the opportunity to take a view, considering culture results..

My two cents (or pence)..important topic which requires nuanced approach. Very hard (imo) to affect change at point of starting empirical Abx. If you have a 28 weeker in front of you with signs, difficult to rule out sepsis and you know mortality very high if un/partially treated.