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Posts by Edward Pimentel

This black-and-white photograph captures Marie Maynard Daly (1921–2003), the trailblazing American biochemist who became the first Black woman to earn a Ph.D. in chemistry in the United States (Columbia University, 1947), at work in her laboratory. Centered in the frame, Daly leans slightly forward with quiet intensity, her gaze directed downward in deep concentration at the scientific glassware she holds with practiced precision: a slender glass pipette in her right hand and a small test tube or vial in her left, as if carefully transferring a liquid during an experiment. She wears a crisp white lab coat unbuttoned at the front, revealing a dark dress or skirt beneath and a boldly contrasting scarf tied neatly at her neck; her short, wavy dark hair is neatly styled, and a pen peeks from her coat pocket. The mid-20th-century laboratory setting envelops her with authentic period detail—white tiled walls, wooden cabinets with glass doors stacked high with books and papers, a cluttered wooden desk, a tall stool, a visible refrigerator, scattered beakers and equipment on the bench, and even a fire extinguisher mounted on the wall—creating a sense of purposeful, hands-on scientific discovery. The composition places Daly as the clear focal point, her figure framed by the ordered chaos of research tools and notes, conveying a mood of focused dedication, intellectual rigor, and quiet empowerment. This historic image endures as a powerful symbol of Daly’s groundbreaking legacy: her pioneering studies on cholesterol’s role in heart disease, protein synthesis, and nucleic acids helped shape modern biochemistry, while her lifelong advocacy opened doors for women and people of color in STEM fields.

This black-and-white photograph captures Marie Maynard Daly (1921–2003), the trailblazing American biochemist who became the first Black woman to earn a Ph.D. in chemistry in the United States (Columbia University, 1947), at work in her laboratory. Centered in the frame, Daly leans slightly forward with quiet intensity, her gaze directed downward in deep concentration at the scientific glassware she holds with practiced precision: a slender glass pipette in her right hand and a small test tube or vial in her left, as if carefully transferring a liquid during an experiment. She wears a crisp white lab coat unbuttoned at the front, revealing a dark dress or skirt beneath and a boldly contrasting scarf tied neatly at her neck; her short, wavy dark hair is neatly styled, and a pen peeks from her coat pocket. The mid-20th-century laboratory setting envelops her with authentic period detail—white tiled walls, wooden cabinets with glass doors stacked high with books and papers, a cluttered wooden desk, a tall stool, a visible refrigerator, scattered beakers and equipment on the bench, and even a fire extinguisher mounted on the wall—creating a sense of purposeful, hands-on scientific discovery. The composition places Daly as the clear focal point, her figure framed by the ordered chaos of research tools and notes, conveying a mood of focused dedication, intellectual rigor, and quiet empowerment. This historic image endures as a powerful symbol of Daly’s groundbreaking legacy: her pioneering studies on cholesterol’s role in heart disease, protein synthesis, and nucleic acids helped shape modern biochemistry, while her lifelong advocacy opened doors for women and people of color in STEM fields.

Biochemist Marie M. Daly (b. #OTD in 1921) was the first Black woman to earn a Ph.D. in #chemistry in the US (Columbia 1947).

Overcoming the dual hurdles of racial & gender bias, her pioneering studies included cholesterol’s role in heart disease, protein synthesis, and nucleic acids. #WomenInSTEM

6 days ago 540 115 1 2
This black-and-white studio portrait photograph captures Rosalind Elsie Franklin, the brilliant British chemist and X-ray crystallographer whose meticulous research produced Photograph 51—the iconic X-ray diffraction image that revealed DNA’s double-helix structure and proved pivotal to the 1953 Watson-Crick model of the molecule. Shown in a close-up, three-quarter view from the shoulders up, Franklin appears in her late twenties or early thirties, her dark, wavy hair neatly styled and swept back from her face. She wears a simple, dark collared blouse or shirt with a crisp, professional appearance that reflects the understated elegance typical of mid-20th-century scientific women. Her expression is calm and intensely focused: direct gaze slightly off-camera to the viewer’s left, lips gently closed in a subtle, knowing half-smile, conveying quiet confidence, intellectual depth, and quiet determination. The plain, softly lit studio background with its neutral gradient emphasizes her face and upper torso, creating an intimate, timeless composition that places her poised presence at the absolute center.

This black-and-white studio portrait photograph captures Rosalind Elsie Franklin, the brilliant British chemist and X-ray crystallographer whose meticulous research produced Photograph 51—the iconic X-ray diffraction image that revealed DNA’s double-helix structure and proved pivotal to the 1953 Watson-Crick model of the molecule. Shown in a close-up, three-quarter view from the shoulders up, Franklin appears in her late twenties or early thirties, her dark, wavy hair neatly styled and swept back from her face. She wears a simple, dark collared blouse or shirt with a crisp, professional appearance that reflects the understated elegance typical of mid-20th-century scientific women. Her expression is calm and intensely focused: direct gaze slightly off-camera to the viewer’s left, lips gently closed in a subtle, knowing half-smile, conveying quiet confidence, intellectual depth, and quiet determination. The plain, softly lit studio background with its neutral gradient emphasizes her face and upper torso, creating an intimate, timeless composition that places her poised presence at the absolute center.

Chemist & X-ray crystallographer Rosalind Franklin's meticulous research was instrumental in uncovering DNA's molecular structure.

Most famous for her role in the DNA double helix discovery, her work also revolutionized our understanding of viruses & coal. Died #OTD in 1958, age 37. #WomenInSTEM

6 days ago 611 140 18 10
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Directed evolution of APOX for proximity labeling using phenols with high redox potentials Proximity labeling (PL) can identify endogenous proteins in specific subcellular regions. APEX2 (enhanced ascorbate peroxidase 2) enables PL with high…

New Martell Group paper alert! www.sciencedirect.com/science/arti... Cool work by Sifei Fang evolving APEX2 for proximity labeling probes with higher redox potentials! Amazing to see this project published.

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It's that time of year again! #ACSFall2026 abstracts are due this Monday, March 30! Submit to the #ACSBIOL Division here: acsnm272.abstractcentral.com

3 weeks ago 4 2 0 0
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a man in a suit and tie is standing next to another man in a yellow shirt and tie . ALT: a man in a suit and tie is standing next to another man in a yellow shirt and tie .

That unbalanced centrifuge in Project Hail Mary #chemchat

4 weeks ago 2 0 0 0

Honored to have been selected again for the 2026 CAS Future Leaders Top 100 initiative - congrats to the 2026 CAS Future Leaders awardees! Such a great program.

1 month ago 1 1 0 0
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Bioengineers develop novel method to read proteins A “reverse translation” technique converts protein sequences into DNA, enabling unprecedented detection sensitivity.

Amazing work by labmate, Liwei - DNA-encoded protein sequencing! Check out Stanford's write-up: news.stanford.edu/stories/2026... #chemchat

1 month ago 1 0 0 0

And save >80% on the cost by pooling 6 or more plasmids into a single sample using our free SAVEMONEY algorithm!

elifesciences.org/articles/88794

colab.research.google.com/github/Masaa...

2 months ago 101 34 8 2

Follow @inprep.bsky.social for the best #ScienceSatire anywhere!

2 months ago 8 2 0 0

Amazing work by my former labmate, Ashley and collaborators in the @chembiobryan.bsky.social group!

2 months ago 1 0 0 0
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How Scientists Learn to Tell Their Research Story | CAS Future Leaders™
How Scientists Learn to Tell Their Research Story | CAS Future Leaders™ YouTube video by CAS, a division of the American Chemical Society

Did you know that narratives can generate interest in your research? @storycollider.bsky.social provides #CASFutureLeaders with skills for effective storytelling. If you're a Ph.D. student or postdoc, apply for the 2026 program by January 25. www.cas.org/about/future... youtu.be/3J9LvBqM8XY?...

3 months ago 3 3 0 0
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Lighting a better path for biobased furans Photocatalytic hydrolysis offers a shortcut for renewable chemicals

Researchers have developed a light-driven catalytic method to hydrolyze furans, offering a more efficient way to exploit them in biorefineries. cen.acs.org/synthesis/gr... #chemsky 🧪

3 months ago 3 1 0 1
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New reagents take the burn out of butyllithium Merck KGaA's non-pyrophoric butyllithium in poly(α-olefin) oil make BuLi stable to air and water

Dissolved in poly(alpha-olefin) oil, the reagents don’t ignite or smoke in air, making them easier to handle and less prone to degradation on storage, while maintaining performance across a range of reaction types.

3 months ago 11 6 0 1
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Lucky manufacturing glitch of the week: finding 0.5 mL centrifuge tubes mixed in with the 1.5 mL tubes we ordered. It's like finding the plastic baby figurine in your slice of the king cake! @eppendorf.bsky.social #chemchat 🧪

3 months ago 7 1 1 0
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Computational design of conformation-biasing mutations to alter protein functions Conformational biasing (CB) is a rapid and streamlined computational method that uses contrastive scoring by inverse folding models to predict protein variants biased toward desired conformational sta...

Amazing work from the @aliceyting.bsky.social lab! Especially cool to see the functional effect of the conformational biasing on enzyme activity. www.science.org/doi/10.1126/...

3 months ago 0 0 0 0

Cool new chemistry for covalent ligand development targeting arginine 👏

3 months ago 39 7 1 0

Very cool work in this preprint from the Krishnan lab!

4 months ago 1 1 1 0
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Forbes 30 Under 30 2025: Science Inventing the future from the atom up

Amazing to see two of my Soh Lab teammates on the #ForbesUnder30 Science list today: Congratulations Yihang and Yahao! www.forbes.com/30-under-30/...

4 months ago 0 0 0 0
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This is an amazing program. Check it out and apply!

4 months ago 1 1 0 0
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Check out our review on DNA-scaffolded catalysis! This link provides free full text access until the end of 2025: authors.elsevier.com/a/1m43W9CpcY.... Big thanks to co-authors @edwardpimentel.bsky.social , Ashley Ogorek, @ethan-hartman-125.bsky.social , and Caleb Cox

5 months ago 14 6 1 0

For full text: authors.elsevier.com/a/1m43W9CpcY...

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Redirecting

Our mini-review on DNA-scaffolded catalysis is out today in @cp-trendschem.bsky.social! It's an interesting look at this unique intersection of catalysis, DNA nanotechnology and supramolecular chemistry. Give it a read! #chemsky doi.org/10.1016/j.tr...

5 months ago 3 1 1 0
Orca Sciences

Just stumbled across Orca Sciences' technical articles. Interesting reads! www.orcasciences.com/reading-diff...

5 months ago 0 0 0 0
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RNA structure prediction is hard. How much does that matter? 4.8k words, 22 minute reading time

Interesting article about RNA structure prediction - we're always wishing we had better structure prediction tools for aptamers, and this article sums up the challenges very neatly! www.owlposting.com/p/rna-struct...

6 months ago 1 0 0 0
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Stereo-reversed E2 unlocks Z-selective C–H functionalization The stereoselective functionalization of C–H bonds represents a central challenge in modern organic synthesis. Despite decades of innovation in C–H activation chemistry, methods for Z-selective functi...

In @science.org this week @zachwickens.bsky.social and collaborators find a way to do Z-selective elimination using thianthrenium chemistry in a versatile route to Z olefins.

chemsky 🧪

www.science.org/doi/10.1126/...

7 months ago 36 9 0 1
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An Alkyne-Directed Cleavage Approach for Activity-Based Cu(I) Sensing Reveals Manganese-Promoted Sensitization of Cuproptosis Copper is an essential element for sustaining life. However, disruptions in copper homeostasis underpin disease, as illustrated by cuproptosis, an emerging form of cell death resulting from aberrant a...

Happy to share our latest in @jacs.acspublications.org led by Xiao and @genlichem.bsky.social on a new activity-based sensing probe for Cu(I) using a fast alkyne-directed cleavage reaction to discover Mn-sensitized #cuproptosis as a novel type of metal-metal crosstalk! pubs.acs.org/doi/abs/10.1...

7 months ago 42 8 1 2
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Discovery of high-specificity DNA aptamers for progesterone using a high-throughput array platform Aptamer-based biosensors offer several advantages for detecting small molecules, including chemical stability and compatibility with diverse sensing formats. However, developing highly specific DNA ap...

New preprint from the Soh lab! Nice work by my labmate Haji - new highly specific steroid aptamers identified using our modified sequencer platform! These don't have the 3wj structure and promiscuity of previous aptamers - I've used it myself! #chemsky www.biorxiv.org/content/10.1...

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#chemsky 🧪

7 months ago 3 2 0 0
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Great perspective by @dereklowe.bsky.social on recent advances in cell surface #glycoRNA biology, including new work from @raflynn5.bsky.social and collaborators identifying an immune silencing effect of N-glycans on activation of TLRs by Acp3U-RNA (www.nature.com/articles/s41...)

7 months ago 29 8 1 0