With a bit of a delay, I’m very excited to welcome Anna Cavagnoli, the first PhD student of Gabriele Lab! lnkd.in/ddY5Y-bz 🎉🎉🎉
Anna is enrolled in the very first cycle of the Science and Technology for Advanced Therapies PhD program at the Scuola Universitaria Superiore Pavia!

Welcome to Sabrina Savoia and Ilaria Locatelli, the first members of the lab! We are officially operative! 🥳 gabrielelab.com/team

At SR-Tiget we are seeking outstanding mid-career scientists in Computational biology, AI, and Molecular immunology who wish to translate their results into therapeutic advances with a focus on genetic diseases! Deadline 1st September 2025! www.linkedin.com/posts/sr-tig...

Are you a mid-career group leader in computational bio/AI/molecular immunology who wants to move the lab to Italy? (preferentially from USA?) The SR-TIGET (Milan, Italy) is recruiting someone like you! Here the call:
back.fondazionetelethon.it/uploads/2025...

Have you recently finished your PhD and had excellent productivity? Telethon foundation is starting a postdoctoral program with a competetive 3-years fully funded position! Send CV and PI preference (included me, I am not yet in the website) details here: back.fondazionetelethon.it/uploads/2025...

3/
We ran simulations to estimate EP search times based on 1) measured subdiffusion, 2) physical/genomic distance. Within 300nm (~<200 kb), a gene can find 1000s of enhancers in minutes. Such encounters can’t be selective → EP selectivity needs other mechanisms, e.g. biochemical

This new preprint from my labmates provides a new perspective on chromatin dynamics! Strongly suggested to everyone into chromatin given its broad impact!

Thank you very much!!

I also want to thank all the amazing colleagues I met during these years and the MIT community for all the support, collaborations, scientific discussion, and new lasting friendship, without whose support, all of this would not have been possible!

For now, to hear more details, check the SR-Tiget post and interview!
Now, approaching the end of my American Journey, I want to thank my postdoc mentor, Anders Sejr Hansen, who deeply supported me through the pandemic until the opening of my lab!

In the lab, we will investigate the role of chromatin regulation in development and diseases using a multidisciplinary approach! I will recruit at any level, so stay tuned for job openings, which will follow soon.

SR-Tiget is an excellence reality in Italy where fundamental and clinical research merge to create new gene therapy approaches, and I am honored to open my laboratory with them!

Unveiling the Secrets of Genome Architecture: Michele Gabriele’s Venture… | San Raffaele Telethon Institute for Gene Therapy (SR-Tiget) 📢 Exciting news: welcoming new #talents from the US! ✨  We are thrilled to announce that in the coming months, two new PIs will join SR-Tiget as Group Leaders, bringing their expertise from the United...

📢 New Lab Alert! 📢
I am very excited to share that starting this summer, I will open my laboratory at the San Raffaele Telethon Institute for Gene Therapy (SR-Tiget) in Milan, Italy! www.linkedin.com/feed/update/... #newlab #chromatin #epigenetics #milan #chromatindynamics www.gabrielelab.com

I'm happy to share our work on the neurodevelopmental impact of ADNP mutations in ASD and beyond. It has been an exciting ride to share with @alessandrovitriolo.bsky.social, Mariana, and the people of the Testa and Poot Labs.
Full paper here:
www.biorxiv.org/content/10.1...
Thread below 🧵

Kudos to Marlene and Veronica who lead the experimental and computational part, and @alessandrovitriolo.bsky.social and Giuseppe with whom we shared the supervision! Special thanks to the families of individuals affected by Gabriele de-Vries syndrome who provided samples to generate #iPSCs

I'm proud to share that our modeling of #YY1 haploinsufficiency has just been published! www.nature.com/articles/s41... Using #organoids and #neurons we discovered that YY1 mutations affect the cross-talk between cells and also cause a non-cell autonomous phenotype in a cell-type specific manner.

Multiscale footprints reveal the organization of cis-regulatory elements - Nature We developed PRINT, a computational method that identifies footprints of DNA–protein interactions from bulk and single-cell chromatin accessibility data across multiple scales of protein size.

Finally out on @nature.com the last study from @jbuenrostro.bsky.social lab in which they developed a method for tracking transcription factor and nucleosome binding using single-cell ATAC-seq and deep learning that allows TF footprinting!! www.nature.com/articles/s41...

Starting 2025 with a genome architecture paper about absolute quantification of looped states, lead by James Jusuf!