Kosmos: An AI Scientist for Autonomous Discovery - preLights Helping researchers from start to finish. Kosmos aids the research workflow by reading the literature, proposing hypotheses, generating and running analyses, and producing traceable, reproducible repo...

Discussing #arXiv preprint 'Kosmos: An AI Scientist for Autonomous Discovery' 🤖

Manuel Lessi & @ramadio.bsky.social share their excitement and worries + discuss possible uses of Kosmos. Includes a lovely graphic created by Theodora M Stougiannou

#preLight⬇️
prelights.biologists.com/highlights/k...

Wikipedia is needed now more than ever, 25 years on The online encyclopedia is an antidote to an increasingly poisoned information ecosystem. Researchers should help to nourish it.

Wikipedia is an antidote to an increasingly poisoned information ecosystem

go.nature.com/4pXIv2d

Xun Cao, Yiming Peng, Mengyuan Yang, Daisuke Takao and colleagues (Huazhong Agricultural University) present a high-content image-based phenotyping pipeline for quantitative analysis of organelle morphology. rupress.org/jcb/article/...

Matrix viscoelasticity regulates dendritic cell migration and immune priming - preLights The physics behind the immune response: focus on viscoelasticity

The physics behind the immune response: focus on viscoelasticity

@ramadio.bsky.social covers a #mooneylab #preprint

"In this work, the authors devise a system capable of tuning viscoelasticity of collagen I independently of stiffness..."

#preLight ⬇️
prelights.biologists.com/highlights/m...

MLKL activates the cGAS-STING pathway by releasing mitochondrial DNA upon necroptosis induction Necroptosis drives inflammation through membrane rupture-mediated DAMPs release. Independently of membrane damage, Ding et al. revealed phosphorylated MLKL permeabilizes mitochondrial membranes and in...

#WeekendRead! #NoTimeToDie! #InterferonPower! Wang &co show @cp-molcell.bsky.social that MLKL not only drives #necroptosis but also directly triggers IFNb production by releasing mitochondrial DNA & activating cGAS-#STING, which exacerbates #colitis! www.cell.com/molecular-ce...

On the importance of reading (just not too much) The real fun of being a neuroscientist, and maybe the key to asking and answering new questions, is to think big and take intellectual risks.

On the importance of reading (just not too much)

www.thetransmitter.org/craft-and-ca...

An immunomechanical checkpoint PYK2 governs monocyte-to-macrophage differentiation in pancreatic cancer - preLights Macrophages sense and adapt. Immuno-mechanics meets cancer research

Macrophages sense and adapt.

@ramadio.bsky.social highlights work from Xie & colleagues.

Roberto: “The huge amount of data presented in this preprint is of high value not only to cancer biologists, but also to cell biologists and clinicians”

#preLight ⬇️
prelights.biologists.com/highlights/a...

New review alert📢
Working on cDC1 and cancer? Take a look👀👇

doi.org/10.1136/jitc...

Discovery of a Potent and Selective Inhibitor of Human NLRP3 with a Novel Binding Modality and Mechanism of Action - preLights Targeting the root of NLRP3 inflammation

Targeting the root of NLRP3 inflammation 🎯

This #preprint from Rebecca Coll & team “highlights the complexity of immune signaling and the importance of considering many variables (...) when developing (…) therapeutic compounds.”

#preLight by Roberto Amadio
prelights.biologists.com/highlights/d...

KLF2 maintains lineage fidelity and suppresses CD8 T cell exhaustion during acute LCMV infection Naïve CD8 T cells have the potential to differentiate into a spectrum of functional states during an immune response. How these developmental decisions are made and what mechanisms exist to suppress d...

#MysterySolved! The Joshi lab &co show @science.org that KLF2 enables CD8 T cells to remain effector cells, proving that differentiation toward the exhaustion lineage is actively suppressed, with consequences for #tumor responses! #ScienceSavesLives www.science.org/doi/10.1126/...

Text: EMBO is on Bluesky. Butterfly icon with text: @embo.org

Hello everyone on Bluesky! 🧪

We are EMBO, the organization of more than 2,100 leading researchers that promotes excellence in #lifesciences in Europe and beyond.

Read more: www.embo.org/about-embo/m...

WASp activity in macrophages prevents mechano-induced inflammation by protecting the nuclear envelope Mutations in the immune-specific actin regulator WASp induce a proinflammatory state in myeloid cells, whose underlying causes remain poorly defined. Here, we applied microfabricated tools that mimic ...

Happy to share the preprint of the main work of my PhD 🙌

doi.org/10.1101/2024...