I’m pleased to share that I’ve been awarded an Independent Investigator Grant from @RallyFoundation for Childhood Cancer Research to support our research on regenerating #thymic function.

Grateful to be part of this mission.

Let’s #RallyOn and stay #GOLDSTRONG for every child and family affected.

Nicholas Restifo: A Breakthrough Year for T Cells - OncoDaily Nicholas Restifo: A Breakthrough Year for T Cells / cancer, CAR-T therapy, immunotherapy, Nature, Nicholas Restifo, OncoDaily, Oncology

Great overview oncodaily.com/blog/nichola...

Hello, #MedSky community! We’re excited to begin our Bluesky journey.

Here is a sampling of the trusted, influential, and essential information you can expect when you follow us:

Antiviral potential of Vδ2 T-cells in children given TCR αβ/CD19 cell depleted HLA-haploidentical HSCT - PubMed γδ T-cells represent key players in the immune-surveillance after TCR alpha/beta (αβ)/CD19-depleted HLA-Haploidentical Stem Cell Transplantation (haplo-HSCT). Although encouraging data are available o...

Our recently published work in collaboration with our neighbor gdT cell experts - Chiara Agrati Lab - on the antiviral activity of Vδ2 T cells in haplo-HCT recipients
pubmed.ncbi.nlm.nih.gov/39626282/

Programming tissue-sensing T cells that deliver therapies to the brain To engineer cells that can specifically target the central nervous system (CNS), we identified extracellular CNS-specific antigens, including components of the CNS extracellular matrix and surface mol...

Wowza! Lim lab drops bombs in 2s! www.science.org/doi/10.1126/...

www.science.org/doi/10.1126/...

Max deserves a Nobel. In the meantime, you can nominate someone for the Max Cooper Prize, deadline is April 1st.

"Nomination letters of up to 3 pages must articulate how their research has led to advances in immunology research that will have a lasting impact."
#Immunology

On my way to @ash-hematology.bsky.social #ASH24 & sharing this starterpack for HCT, #CARTcells & #genetherapy - > 100 members DM/comment if I missed someone #bmtsm #mmsm #leusm #lymsm #sicklecell #mpnsm #medsky

go.bsky.app/7xxh8WW

It doesn't seem to have major effects

Hi Miguel. I was looking for such starterpack. Please add me. Safe travels

RANKL treatment restores thymic function and improves T cell–mediated immune responses in aged mice RANK ligand administration reversed age-dependent thymic involution and rejuvenated T cell immunity in mice.

www.science.org/doi/10.1126/...

A spatial human thymus cell atlas mapped to a continuous tissue axis T cells develop from circulating precursor cells, which enter the thymus and migrate through specialized subcompartments that support their maturation and selection1. In humans, this process starts in...

To #ThymuSky folks. A quantitative morphological framework for the human #thymus during development
pmc.ncbi.nlm.nih.gov/articles/PMC...

Tissue determinants of the human T cell receptor repertoire 98% of T cells reside in tissues, yet nearly all human T cell analyses are performed from peripheral blood. We single-cell sequenced 5.7 million T cells from ten donors’ autologous blood and tonsils a...

Here is out first attempt to understand #TCR #repertoire in human tissues -Tissue determinants of the human T cell receptor repertoire Around 6 million T cells profiled at #single #cell #level www.biorxiv.org/content/10.1...

I would love to be part of the T cells starting pack and the #thymusky seems something absolutely necessary 😀

SARS-CoV-2 infection of thymus induces loss of function that correlates with disease severity Lymphopenia, particularly when restricted to the T-cell compartment, has been described as one of the major clinical hallmarks in patients with coronavirus disease 2019 (COVID-19) and proposed as an i...

This is very interesting and I do wonder how much this is due to dysregulated thymic function, which we showed is a target of Sars-cov-2 virus pubmed.ncbi.nlm.nih.gov/36758836/

Pediatric brain tumor patients display altered immune activation and reduced lymphopoiesis at the onset of disease - npj Precision Oncology npj Precision Oncology - Pediatric brain tumor patients display altered immune activation and reduced lymphopoiesis at the onset of disease

Very excited to write my first post and share our lab latest paper with this (renewed) community!
Big thanks to my lab and all co-authors for the huge effort and the collaborative opportunity!

www.nature.com/articles/s41...