Glutathione is critical for NK cell-mediated immunity Guerra et al. show that glutathione (GSH) sustains IL-15-driven NK cell metabolism and effector functions. Loss of GSH unleashes T cell immunity and improves viral clearance. In contrast, NK cell-medi...

Glutathione is critical for NK cell-mediated immunity: Cell Reports www.cell.com/cell-reports...

This Brazilian frog might be the first pollinating amphibian known to science Nectar-loving tree frog likely moves pollen from flower to flower

It’s the first time a frog—or any amphibian—has been observed pollinating a plant, researchers reported in 2023.

Learn more on #WorldWildlifeDay: https://scim.ag/4riUU1G

Super Salva with the immunology facts! And just in time for the start of hay-fever season. 🌿

Ectopic expression of cytosolic DHODH uncouples de novo pyrimidine biosynthesis from mitochondrial electron transport - Nature Metabolism Cytosolic ScURA uncouples de novo pyrimidine synthesis from mitochondrial electron transport, and rescues pyrimidine production and cell proliferation under pharmacological or genetic mETC disruption.

Some beautiful xenotopic synthetic biology to shed light on the importance of pyrimidine biosynthesis in cells with a defective ETC!
www.nature.com/articles/s42...

Excessive #inflammation?
We uncover @cp-immunity.bsky.social that #IFN-I via #ISG15 in macrophages lowers #mitochondrial membrane potential, boosts #efferocytosis, and self limits #ISG amplification: a built in brake that promotes resolution. Open-access: www.cell.com/immunity/ful...
#immunosky

Single Cell Glucose Uptake Assays: A Cautionary Tale Assays to monitor the metabolic state or nutrient uptake capacity of immune cells at a single cell level are increasingly in demand. One assay, used by many immunologists, employs 2-(N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)Amino)-2-Deoxyglucose ...

****2-NBDG does not measure glucose uptake****

Just your regular reminder of this fact 😁.

See the rigorous proof of this fact in @lindavsinclair.bsky.social 2020 paper.

This paper was 6 years ago!! Stop using 2NBDG to measure glucose uptake already 🙄

pmc.ncbi.nlm.nih.gov/articles/PMC...

Very interesting pre-print comparing cell culture media with physiologically available metabolic substrate levels www.biorxiv.org/content/10.1...

The best science images of 2025 — Nature’s picks The Sun’s fiery surface, a tattooed tardigrade, rare red lightning and more.

www.nature.com/immersive/d4...

[Dance.

Exeunt.]

IFI16 senses and protects stalled replication forks Gamble et al. demonstrate that detection of stalled replication forks by the innate immune sensor IFI16 induces an early STING-dependent pro-inflammatory cytokine response independently of cGAS and DNA damage. Furthermore, IFI16 exhibits dual functionality during replication stress by protecting stalled, remodeled replication forks from nucleolytic degradation.

Online Now: IFI16 senses and protects stalled replication forks Online now:

Architecture of the neutrophil compartment - Nature Mapping of the neutrophil compartment using single-cell transcriptional data from multiple physiological and patological states reveals its organizational architecture and how cell state dynamics and trajectories vary during health, inflammation and cancer.

Nature research paper: Architecture of the neutrophil compartment

go.nature.com/4oD2Nh5

Metabolites are not genes — avoiding the misuse of pathway analysis in metabolomics - Nature Metabolism Pathway analysis, originally developed for gene expression data, has been adapted for metabolomics. However, owing to the unique characteristics and constraints of metabolites compared with genes, pathway analysis in metabolomics often yields misleading or nonsensical results.

www.nature.com/articles/s42...

RFK Jr’s health department to halt $500m in mRNA vaccine research Agency to end 22 federal contracts, questioning safety of technology credited with helping end Covid pandemic

What a shame.
www.theguardian.com/us-news/2025...

This month Mr. @aitorjarit.bsky.social became (very deservedly) Dr. Aitor with a great thesis! Super interesting discussion during the defense with the input of the wise committee - lots of cool experiments to do 🧪🔬❤️

🌟Proud to share our latest research: "Imidazole propionate (ImP) is a driver therapeutic target in atherosclerosis" in
@nature.com A step toward early diagnosis & targeted therapy in cardiovascular care! #metabolites #impact #PersonalizedMedicine 👇🧵https://www.nature.com/articles/s41586-025-09263-w

Woah, very cool study, relevant for mRNA vaccine success.

A sweet spot in myeloid cell pro-tumoral functions The regulation of myeloid cell responses can determine tumor outcomes. In this issue of Immunity, Blidner et al. report that galectin-1 triggers both …

Our preview of the cool work from the Rabinovich lab in this issue of Immunity:
www.sciencedirect.com/science/arti...

This week the world gained another Doctor of Immunology, and we are all the richer for it! Congratulations Dr. Irene on a great thesis and defense. Thank you to the examiners for the interesting discusion and to @sancholab.bsky.social for cosupervising with me these years - it has been a pleasure!

Lab-kept bumble bees roll small wooden balls around for no apparent purpose other than fun, a 2022 study reveals.

Learn more on #WorldBeeDay: scim.ag/4dAwCuD

France and EU to incentivise US-based scientists to come to Europe Macron and von der Leyen expected to announce protections for researchers seeking to relocate amid Trump’s crackdown

I do not see a lack of scientific talent in the EU. I see a lack of job opportunity and stability, with great scientists being forced to leave their home country to do what they love.

France and EU to incentivise US-based scientists to come to Europe www.theguardian.com/world/2025/m...

Immunotherapy with conventional type-1 dendritic cells induces immune memory and limits tumor relapse - Nature Communications Dendritic cells (DCs) induce infection-protective immune memory, which has yet to be exploited for cancer therapy. Here we show that type 1 DC vaccines quantitatively and qualitatively favors anti-tum...

Put a dendritic cell (DC) in your tumor #immunotherapy!
cDC1-based vaccines induce strong effector & memory anti-tumor T cell response. Improved immune memory prevents tumor relapse! #CNIC @ageinves.bsky.social @contracancerinv.bsky.social
www.nature.com/articles/s41...
#immunosky #cancersky (1/7)

Cells are swapping their mitochondria. What does this mean for our health? Nature - Researchers are studying why the energy factories are moving between cells and whether the process can be harnessed to treat cancer and other diseases.

Researchers are studying why mitochondria are moving between cells and whether the process can be harnessed to treat cancer and other diseases

https://go.nature.com/3RcyzDa

So cool! A very functional relevance of the Nrf2-Keap1 axis 🐎

A fresh look at the T helper subset dogma - Nature Immunology Single-cell-sequencing techniques enable the decades-old T helper subset dogma to be re-examined in an unsupervised manner, bringing nuance to the definition of known subsets while simultaneously iden...

And it gives me the chance the highlight the best CD4+ T cell/ice cream crossover review:
doi.org/10.1038/s415...

Mitochondrial response to fever boosts TH1-driven... : Immunometabolism n. In a recent study, Heintzman, et al investigated the effect of febrile temperature (39 °C) on T cell function. They describe increased TH1 function and fitness accompanied by a decrease in regulato...

I really enjoyed writing this research highlight with @sancholab.bsky.social
The original paper from the Rathmell lab answers many questions and opens the way for many more!
journals.lww.com/immunometabo...

Congratulations Iñaki et al.! 🦴🦠💕