Always a pleasure to work with you!

#NucleicAcidsResearch #Epigenetics #Adipocytes #Metabolism #UCP1 #SUMOylation
@ncmbm.bsky.social

Research supported by @biovitenskap.bsky.social @uio.no The Research Council of Norway, UNIFOR, @kreftforningen.

These results suggest that temporally controlled SUMO pathway inhibition could be a novel strategy to modulate adipose tissue thermogenic capacity.

Key findings include:
· Transient TAK-981 exposure leads to robust and stable induction of beiging genes, including UCP1, and increased mitochondrial respiration.
· Mechanistic insights reveal immediate chromatin and enhancer activity remodeling and mobilization of CEBP family members and PPARG.

We investigated how the SUMOylation pathway regulates adipocyte plasticity. We discovered that brief pharmacologic inhibition of SUMOylation primes human pre-adipocytes for stable de novo beige differentiation when combined with PPARG activation.

Excited to share that our latest research has been published in @narjournal.bsky.social
Read the article here: academic.oup.com/nar/article/...
Congratulations to Patrizia Nothnagel and many thanks to all people involved including Nolwenn Briand, Bjørn Steen Skålhegg and @amathelier.bsky.social.

Many thanks to the organisers, sponsors, and members of the poster award committee for this prize and the wonderful conference. The work is supported by The Research Council of Norway.
@biovitenskap.bsky.social @embo.org @uio.no

🌟 Congratulations to my PhD student Patrizia Nothnagel! 🌟
Patrizia won the "SUMO" poster award at the 2025 EMBO workshop "SUMOylation: From Discovery to Translation" in La Grande-Motte, France. Her work has paid off, and I am proud of her.

Many thanks to @biovitenskap.bsky.social and the research council of Norway for supporting this study and @igbmc.bsky.social sequencing facility for processing our samples.

IRX3 buffers the SUMOylation to promote adipogenesis and block osteogenesis. IRX3 loss boosts SUMOylation, inhibits PPARγ, and pushes cells toward bone fate, which is reversible with SUMOylation inhibition.
IRX3 is an epigenetic gatekeeper.
#Epigenetics #Adipogenesis #ObesityRisk #SUMOylation

IRX3 controls a SUMOylation-dependent differentiation switch in adipocyte precursor cells Nature Communications - Here, the authors show that IRX3 is a transcriptional master regulator of multiple histone- and chromatin-remodeling enzymes and the SUMOylation pathway in adipocyte...

I am delighted to share a publication in @natcomms.nature.com. IRX3, linked to obesity via the FTO locus, influences fat vs bone cell fate. It is the result of a wonderful collaboration between S. Dankel, G. Mellgren @unibergen.bsky.social and my lab @biovitenskap.bsky.social 🍾
👉 rdcu.be/ezA5o

Postdoctoral Research Fellow in Molecular Biology and Epigenetics (279366) | University of Oslo Job title: Postdoctoral Research Fellow in Molecular Biology and Epigenetics (279366), Employer: University of Oslo, Deadline: Thursday, May 15, 2025

We are extending the application deadline for this post-doc position! Do not miss the opportunity to join an exciting project in a dynamic and collaborative research environment. @igbmc.bsky.social @pasteur.fr @univbordeaux.bsky.social @uio.no #epigenetics #cellfate #SUMOylation @ncmbm.bsky.social

Z-DNA formation induces the totipotent-like state and primes Zscan4-dependent chromatin compartmentalization A remarkable transition during murine development is the progression from the 1-cell embryo to the 2-cell stage, accompanied by the activation of a specific set of embryonic genes, epigenome reprogram...

Totipotent-like cells in early mouse embryos reorganize their genome via Z-DNA and Zscan4-driven interactions to form a “Z compartment” first supporting ZGA and later compartmentalisation to safeguard the totipotent-like state. Chromatin plasticity at its finest!
www.biorxiv.org/content/10.1...

Thank you @alexis-verger.cpesr.fr !!
I could say the same about you 👍

For this project we collaborate with @amathelier.bsky.social @ncmbm.bsky.social

Transcriptional Regulation Of Cell Fate - Department of Biosciences We investigate the mechanisms regulating chromatin and gene expression during cellular differentiation and cell cycle progression in yeast and mammals.

www.mn.uio.no/ibv/english/...

Postdoctoral Research Fellow in Molecular Biology and Epigenetics (279366) | University of Oslo Job title: Postdoctoral Research Fellow in Molecular Biology and Epigenetics (279366), Employer: University of Oslo, Deadline: Thursday, May 15, 2025

This is a 3-year, full-time position in an international research environment.
This position is funded by the Research Council of Norway.
🗓 Start date: ASAP
📅 Deadline: May 15, 2025
Apply here: www.jobbnorge.no/en/available...

We’re Hiring!
I am seeking a Pos-doc Researcher in Molecular Biology and Epigenetics. Join our team @biovitenskap.bsky.social @uio.no to explore how SUMOylation regulates epigenetic fate, gene expression, 3D-genome and chromatin during adipogenesis, with implications for obesity and cancer research.

Multimodal epigenetic and enhancer network remodeling shape the transcriptional landscape of beige adipocytes Epigenetic regulation is a key determinant of adipocyte fate and function, conferring phenotypic plasticity to adipose tissue in response to metabolic and thermal challenges. To understand the spatiot...

This study is a very elegant characterisation of the epigenetic and transcriptional divergence between white and beige adipocytes. Very useful to those studying the epigenetic mechanisms supporting cellular reprogramming.
www.biorxiv.org/content/10.1...

A figure depicting the concept of cancer attractor states within Waddington's landscape, and how gene regulatory network dynamics influence these states. The figure shows how cancerous cells derive from those that have accidentally entered into unused attractor states that are usually unoccupied in developmental trajectories.

Genome sequencing & single-cell transcriptomics continue to produce findings that challenge the idea that #cancer is purely a genetic disease. This Essay delves into #omics data that questions the somatic mutation theory & presents alternative theories based on GRNs & tissue fields.🧪
plos.io/3DRtAEW

As TAK-981 is in clinical trial for cancer, these findings highlight the need to consider its potential metabolic effects.
Nice collaboration between my group at @uio.no @biovitenskap.bsky.social, Antoine Martinez @ucauvergne.bsky.social
#Adipogenesis #SUMOylation #Metabolism #InVivo #CancerTherapy

Pharmacological inhibition of SUMOylation with TAK-981 mimics genetic HypoSUMOylation in murine perigonadal white adipose tissue Post-translational modification by the small ubiquitin-like modifier (SUMO) is essential for cellular differentiation and homeostasis. Here, we investigate the role of SUMOylation in adipose tissue...

Our recent in vivo study reveals that inhibiting SUMOylation with TAK-981 disrupts fat accumulation, leading to impaired adipogenesis and increased immune cell infiltration in perigonadal white adipose tissue.
www.tandfonline.com/doi/full/10....

A second position will be soon advertised for molecular biologists. Stay tuned!

Postdoctoral Research Fellow in Computational Biology and Epigenetics (273869) | University of Oslo Job title: Postdoctoral Research Fellow in Computational Biology and Epigenetics (273869), Employer: University of Oslo, Deadline: Friday, February 28, 2025

Applications are welcome here: www.jobbnorge.no/en/available...

The project involves integration of ATAC-seq, ChIP-seq, CAGE and HiC experiments to reveal mechanisms that prevent epigenetic and transcriptional drifting during cellular reprogramming with a particular focus on the adipose tissue.

My group @biovitenskap.bsky.social is #hiring a Post-doc in bioinformatics and biostatistics to work on #epigenetic memory in stem cells and during cell reprogramming. The position is co-supervised by @amathelier.bsky.social from @nordicembl.bsky.social

Thanks for sharing the first of the two positions that we will propose in the next 6 months @biovitenskap.bsky.social
Stay tuned!

Thanks @amathelier.bsky.social. The start of a great adventure 😀

Funding to Research on Epigenetic memory - Department of Biosciences Pierre Chymkowitch at the University of Oslo is awarded 12 million NOK by The Norwegian Research Council, to investigate how SUMOylation influences epigenetic stability and could prevent diseases like...

As part of this initiative, two postdoctoral fellowships will soon be advertised. One focusing on Molecular and Cell Biology, and one focusing on bioinformatics and biostatistics.
Stay tuned for more updates and details about these positions!
@chymkowitchlab.bsky.social
www.mn.uio.no/ibv/english/...