#NucleicAcidsResearch #Epigenetics #Adipocytes #Metabolism #UCP1 #SUMOylation
@ncmbm.bsky.social

#β2Microglobulin upregulation in #hypertrophic #adipocytes drives CD8+ T cell activation, iron overload, #ferroptosis, and M1 #MacrophagePolarization, while its ablation or knockdown alleviates obesity-linked inflammation and metabolic disorders.

#STTT: doi.org/10.1038/s413...

🎯And we kick off the year with the Image of the Month for January🗓️

Differentiated 3T3-L1 #adipocytes cultured in a µ-Slide 8 Well high & acquired using Olympus Corporation Fluoview🔬

🥼 Scientific artwork by Lena Richter, @hzdr.bsky.social, Germany

#sciart #bioart #scienceandart #scienceisfun

Protocol for targeted gene manipulation and thermogenic evaluation in mouse brown adipocytes Adeno-associated viruses (AAVs) are versatile, non-integrating vectors for in vivo gene delivery. We present a reproducible workflow for generating Cr…

In @cp-starprotocols.bsky.social we present a protocol for generating and targeting Cre-dependent FLEX-AAVs in vivo, for the assessment of #thermogenesis in brown #adipocytes using #respirometry.
@mcgillgci.bsky.social

Link here👇
www.sciencedirect.com/science/arti...

Adipocytes orchestrate obesity-related chronic inflammation through β2-microglobulin - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Adipocytes orchestrate obesity-related chronic inflammation through β2-microglobulin

#Adipocytes → #obesity-associated chronic #inflammation and metabolic disorders via two @#β2-microglobulin-dependent mechanisms. bit.ly/4poJMA9 [open access]

Elevated #β2Microglobulin in #hypertrophic #adipocytes activates CD8+ T cells, triggers adipocyte #ferroptosis, and promotes #macrophage M1 polarization, driving obesity-linked #inflammation and #MetabolicDisorders.

#OpenAccess in #STTT: doi.org/10.1038/s413...

𝗜𝗣𝗕𝗦 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵𝗲𝗿𝘀 𝗶𝘀𝗼𝗹𝗮𝘁𝗲𝗱 𝗵𝘂𝗺𝗮𝗻 𝗿𝗲𝗴𝘂𝗹𝗮𝘁𝗼𝗿𝘆 𝗯𝗼𝗻𝗲 𝗺𝗮𝗿𝗿𝗼𝘄 𝗮𝗱𝗶𝗽𝗼𝗰𝘆𝘁𝗲𝘀 𝗳𝗼𝗿 𝘁𝗵𝗲 𝗳𝗶𝗿𝘀𝘁 𝘁𝗶𝗺𝗲!

These anucleate fat cells still metabolize lipids and glucose, support blood cell production, and may shape the bone marrow niche and hematopoiesis.🩸

📖 shorturl.at/bunUV
#Hematopoiesis #Adipocytes #BoneMarrow

Canadian Science Publishing Can't sign in? Forgot your username?

🧪 Can mature #adipocytes really give rise to stem cells?
This study using a murine adiponectin-creERT;mT/mG model confirms: DFAT cells do originate from mature adipocytes—but the resulting population is heterogeneous.
doi.org/10.1139/bcb-...
#StemCells #RegenerativeMedicine

A pleasure to share my experience today to the #SEBBM community and to have the opportunity of discussing about my favourite topics #Adipocytes and #EVs
Thank you all for the opportunity of discussion! 😍🤓

Tumor cell-adipocyte gap junctions activate lipolysis and contribute to breast tumorigenesis - Nature Communications Breast cancer cells interact with neighbouring adipocytes, but the mechanisms are not fully understood. Here, the authors show that triple-negative breast cancer (TNBC) cells transfer cAMP through gap...

How do tumor cells co-opt neighboring #adipocytes to promote #tumorigenesis? @andreigoga.bsky.social and colleagues identify a direct tumor cell-adipocyte interaction that activates lipolysis in triple negative breast cancer models. #SciSky #GeroSky bit.ly/4mRZYYN @natureportfolio.nature.com

Pro-inflammatory signaling in #adipocytes essential for adipose expansion, remodeling, and tissue integrity. Counterintuitive? Suppression of adipocyte #inflammation →tumor-friendly microenvironment →mammary #cancer progression. bit.ly/4k7kKCc

Adipose tissue retains an epigenetic memory of obesity after weight loss - Nature Stable epigenetic changes indicate the existence of an obesogenic memory in mouse adipocytes that primes cells for pathological responses in an obesogenic environment and potentially contributes to th...

Adipose tissue retains epigenetic memory of obesity after weight loss
www.nature.com/articles/s41...
news.ycombinator.com/item?id=4367...

* may prime cells for pathological responses in obesogenic environment contributing to problematic yo-yo effect seen w. dieting
#obesity #epigenetics #adipocytes

Lipid realms🛸

Pre-adipocytes & #beige cells loaded with lipid droplets🦠Stained for F-actin (grey), nuclei (blue) & lipids (depth-coded) in μ-Slide 8 Well chambers. Imaged with #Leica SP8 #Confocal🔬 @leicamicrosystems.bsky.social

🥼 #SciArt by Shuntaro Yamada, @unibergen.bsky.social

#adipocytes

The Lim Lab at the @crchum.bsky.social is recruiting PhD students or Postdoctoral Fellows to study the roles of 14-3-3zeta in #adipocytes or pancreatic #betacells.

Projects are supported by CIHR, NSERC, or Diabetes Canada.

Please share with people who might be interested!

Thanks!

Huo, Wang et al. reveal that #adipocytes experiencing endoplasmic reticulum stress secrete #ceramide in lipoprotein form to #hepatocytes, activating the unfolded protein response by reducing membrane fluidity. rupress.org/jcb/article/...
#ER_literature

New data on intrapancreatic adipocytes and beta cell dedifferentiation in human #Type2Diabetes #Islets #BetaCells #Adipocytes #DiabetesResearch #MedSky

#Adipocytes or fat cells are, arguably, one of the the most interesting cell types to study. I look forward to sharing my work on this platform. #thefatscientist

The GIP receptor activates futile calcium cycling in white adipose tissue to increase energy expenditure and drive weight loss in mice Obesity is a chronic disease that contributes to the development of insulin resistance, type 2 diabetes (T2D), and cardiovascular risk. Glucose-depend…

🍫🔥 The GIP receptor activates futile calcium cycling in white adipose tissue to increase energy expenditure and drive weight loss in mice

🔗 www.sciencedirect.com/science/arti...

#adipocytes #weightloss

Obesity has memory and retains it in cells Research in mice describes a molecular mechanism in fatty tissue that predisposes people to regain weight. This finding could help explain the ‘yo-yo effect’

darn #adipocytes and #evolution!! Interesting study, though! #anatomy #meded #obesity english.elpais.com/health/2024-...

New science and approaches to decrease cardiometabolic risk! S102a #AHA24 #translationalscience #cardiomyocytes #adipocytes

Delighted to share our latest study exploring how #glycolysis pathway alterations in fat body #adipocytes control remotely the integrity of body-wall #muscles in #Drosophila larvae.
Excellent review process by #emboreports
doi.org/10.1038/s443...

Researchers introduce a novel method using low-coherence #holotomography and an automated image analysis tool for long-term #visualization and #quantification of unlabeled #adipocytes and their lipid droplets' biophysical parameters.

www.biorxiv.org/content/10.1...