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Are complex staining protocols or phototoxicity limiting your HCS workflows?
Nanolive’s holotomography + AI delivers live, label-free cell & organelle data for faster, de-risked drug discovery.
Ready to go beyond dyes? bit.ly/4kHgw61
#LiveCellImaging #Holotomography

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Label-free #holotomography for #3DThursday! This imaging technique lets you follow the same living organoid in 4D with no dyes or phototoxicity.

🔬: @tomocube.bsky.social, HT-X1
🧫: Mouse Intestinal #Organoid
🏛️: Institut Pasteur Workshop, Pushing the Frontiers of Dynamic Imaging
🎬: #syGlass, v2.5.0

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📢 𝗧𝗼𝗺𝗼𝗰𝘂𝗯𝗲 𝗶𝘀 𝗵𝗲𝗮𝗱𝗶𝗻𝗴 𝘁𝗼 𝘁𝗵𝗲 𝟭𝘀𝘁 𝗔𝗻𝗻𝘂𝗮𝗹 𝗠𝗲𝗲𝘁𝗶𝗻𝗴 𝗼𝗳 𝗜𝗻𝗱𝗶𝗮 𝗕𝗶𝗼𝗜𝗺𝗮𝗴𝗶𝗻𝗴! Visit our booth to explore how the HT-X1 Series and TomoAnalysis bring label-free 3D clarity and AI-powered insights to your research. @indiabioimaging.bsky.social
#Tomocube #Holotomography

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𝗖𝗢𝗠𝗣𝗔𝗖𝗧 𝗱𝗲𝘀𝗶𝗴𝗻 – 𝗨𝗡𝗖𝗢𝗠𝗣𝗥𝗢𝗠𝗜𝗦𝗘𝗗 𝗾𝘂𝗮𝗹𝗶𝘁𝘆 – 𝗔𝗖𝗖𝗘𝗦𝗦𝗜𝗕𝗟𝗘 𝘁𝗼 𝗲𝘃𝗲𝗿𝘆 𝗹𝗮𝗯

🚀 HT-X1 mini – Tomocube's newest holotomography system, delivering high-resolution, label-free 3D imaging to every lab.

✨ tomocube.com/products/htx...

#HTX1mini #X1mini #X1series #Holotomography #Tomocube

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A developing mouse cochlea captured label-free using the HT-X1 #Holotomography system. The system’s rapid 3D scanning capability reveals detailed microstructures. Meanwhile, a large field of view with an autostitching feature enables hassle-free tile imaging of wide sample areas at high resolution.

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📸 Great moments at #mmc2025!
We’re excited to team up with Photon Lines to showcase Tomocube’s cutting-edge #holotomography solutions—with live demos of the actual X1 system this year!

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Gradient refractive indices enable squid structural color and inspire multispectral materials The manipulation of light by means of materials with varying refractive index distributions is widespread among natural systems and modern technologies. However, understanding how animals leverage ref...

Wonderful news from Tomocube #holotomography users—they've cracked the code on how squid pull off their amazing trick of quickly switching between vibrant color and near invisibility.
👉 Science study: www.science.org/doi/10.1126/...
👉Explore holotomography: tomocube.com/products

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🌿 It’s been an exciting few days for Tomocube at the 16th International Congress of #Protistology (June 22–27, Seoul)! Thanks to everyone who stopped by our booth to explore 3D, label-free live imaging of protists with #Holotomography!

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Live from the KSBMB 38th Seorak Conference in beautiful Gosung, Korea! The stunning beaches might be calling, but we're fully immersed in the exciting world of #holotomography and how our technology is making waves in bioscience. 🌊

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🧬 New study in Methods shows how 3D #Holotomography + AI can detect biliary tract #cancer with up to 97.94% accuracy—based on lipid droplet profiles as metabolic biomarkers.

📖Go to the publication: doi.org/10.1016/j.ym...

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Success! 🎉 Our workshop at the 2025 KBSI AI Imaging School today was met with a full house. It was fantastic to share the power of AI-driven analysis for label-free 3D live cell imaging using #holotomography and we couldn't be more grateful for the incredible engagement!

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Join Tomocube at the world’s leading stem cell and regenerative medicine meeting — ISSCR 2025. Discover how our HT-X1 Series and label-free 3D #holotomography are transforming live-cell imaging and analysis in stem cell research.

#ISSCR #ISSCR2025

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Unlock New Dimensions: Exploring Holotomography's Untapped Potential Date: June 10th, 2025Sessions: 8:00 AM | 2:00 PM | 8:00 PM (UTC/GMT +2) SIGN UP FOR 8:00 AM SIGN UP

A new webinar alert collaborating #crestoptics and @tomocube.bsky.social #tomocube #holotomography

crestoptics.com/unlock-new-d...

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Long-chain sulfatide enrichment is an actionable metabolic vulnerability in intraductal papillary mucinous neoplasm (IPMN)-associated pancreatic cancers Background We conducted an integrated cross-species spatial assessment of transcriptomic and metabolomic alterations associated with progression of intraductal papillary mucinous neoplasms (IPMNs), wh...

New study utilizing #holotomography uncovers biochemical and molecular mechanism underlying the malignant progression of intraductal papillary mucinous neoplasm (IPMN) to pancreatic ductal #adenocarcinoma (PDAC).

gut.bmj.com/content/earl...

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Revealing 3D microanatomical structures of unlabeled thick cancer tissues using holotomography and virtual H&E staining - Nature Communications Acquiring subcellular-level three-dimensional (3D) tissue structures efficiently without damaging the tissue remains challenging in histopathology. Here, the authors integrate holotomography with deep...

A giant leap in #histopathology. Researchers have used our #holotomography tech + deep learning to achieve 3D virtual H&E staining, label-free and up to 50 µm thick (12.5× conventional slides). Truly volumetric, artifact-free visualization.
www.nature.com/articles/s41...

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Diverse bat organoids provide pathophysiological models for zoonotic viruses Bats are important reservoirs of zoonotic pathogens, but suitable model systems for comprehensively exploring host-pathogen interactions and assessing spillover risks remain limited. To address this g...

A new Science-published study unveils a groundbreaking multispecies, multiorgan bat organoid platform—opening the door to deep insights into how zoonotic viruses infect bats and what drives spillover into humans. 🦇🦠 #holotomography

www.science.org/doi/10.1126/...

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Known for their phagocytic (cellular eating) behavior and role in inflammatory responses, RAW 264.7 cells are a go-to model in immunology and drug delivery studies.

Label-free #holotomography imaging of RAW 264.7 cells by the HT-X1 imaging system - single FOV and tile imaging.

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Life beyond labels - Nature Methods Advances in label-free microscopy allow researchers to visualize the invisible in complex biological systems, even living animals, from whole organs down to the tiniest peptides.

Biology is entering a new era, one that sees more while using less. We’re excited to see #holotomography featured in the latest Nature Methods article highlighting the growing shift toward observing biological systems in their natural, unaltered state

www.nature.com/articles/s41...

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🧠 What if you could explore the brain's microstructures—without cutting it into a few-micron-thin slides, staining, or labeling? Tomocube’s second generation #holotomography, a powerful new way to study the brain’s intricate structure in a less disruptive way.

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Come see us at Booth #229 at the Association of Biomolecular Resource Facilities meeting #ABRF2025! 🌟

Chat with our #holotomography experts on new imaging advancements for live cell and organoid research!

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For the first time, the digestive tract, brain, ovaries, salivary glands, muscles, and claws of a live #tardigrade Hypsibius exemplaris have been visualized in remarkable detail (3D and label-free) using #holotomography.

🔗 Read the full paper here: www.mdpi.com/2379-139X/11...

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Arabidopsis trichomes, captured using the HT-X1™ Plus #holotomography, were taken label-free yet depth color-coded into vibrant colors, revealing the unique 3D structures of these unicellular, branched epidermal hairs.
Discover the HT-X1™ Plus here: www.tomocube.com/products/htx1_plus

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March is packed with opportunities to connect and share insights on advanced imaging and analysis! Here’s where you can find Tomocube this month.
Whether you're attending in person or following along online, stay tuned for updates and insights from our team!
#Holotomography

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Bafilomycin A1 induces colon cancer cell death through impairment of the endolysosome system dependent on iron - Scientific Reports Scientific Reports - Bafilomycin A1 induces colon cancer cell death through impairment of the endolysosome system dependent on iron

[Publication alert] New study utilizing #holotomography explores the effects of bafilomycin A1 (BA1) on colon cancer and normal fibroblast cells, revealing its impact on lysosomal stress, iron homeostasis, and lipid metabolism.
www.nature.com/articles/s41...

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#holotomography application.

New insights into the metabolic regulation of brown adipose tissue. Fructose, as the sole carbon source, restricts #lipid accumulation and alters adipogenic gene expression, while glucose promotes lipid droplet formation.

www.biorxiv.org/content/10.1...

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Antimicrobial activity of CuFe2O4 and CuFe2O4/ZnO: Squaring colorimetric and traditional microbiology assays with atomic force- and holotomography-microscopies Intensive research efforts seek the discovery of efficient antimicrobial compounds to fight microbial resistance. Magnetic nanoparticles represent a p…

#Holotomography enabled real-time, label-free visualization of the multifunctional magnetic nanomaterials' interactions with microbial #biofilms, revealing their entry into fungal cells, subsequent cellular damage, and disruption of biofilm structures. Read more
www.sciencedirect.com/science/arti...

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Join Tomocube at the ASBMB Deuel Conference on Lipids, taking place from January 21–24, 2025, at the Hyatt Regency in Long Beach, California. Visit us to explore #holotomography technology for #lipid research, meet the team, and discuss how we can support your research goals.

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A beautiful image showcases the cell migration process in an in vitro wound healing assay. Captured by our #holotomography system, this image reveals cellular dynamics in stunning detail, enabling advanced research into regeneration and repair.
Video: youtu.be/_yCe76CIDm0?...

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Microbial production of food lipids using the oleaginous yeast Apiotrichum brassicae Oleaginous yeasts offer a promising sustainable alternative for producing edible lipids, potentially replacing animal and unsustainable plant fats and…

Imagine replacing animal fats and plant oils with a sustainable alternative produced by #microbes! Researchers have explored the power of oleaginous yeast to create tailored lipid profiles, perfect for various food applications.
www.sciencedirect.com/science/arti...
#holotomography #3Dimaging

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In Vitro Modeling of Atherosclerosis Using iPSC‐Derived Blood Vessel Organoids Induced pluripotent stem cell-derived blood vessel organoids (BVOs) are used to model atherosclerosis by incorporating key atherogenic factors. Atherosclerotic BVOs exhibit pathogenic features such a....

Outstanding work in Advanced Healthcare Materials! Researchers developed induced pluripotent stem cell-derived blood vessel #organoids (BVOs) as an advanced in vitro model for studying #atherosclerosis.

Learn more about the #holotomography application:
onlinelibrary.wiley.com/doi/10.1002/...

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