Single‐cell transcriptomics reveals cellular heterogeneity and phenotypic transitions of smooth muscle cells in aortic dissection We utilized single-cell RNA sequencing (scRNA-seq) to investigate cellular heterogeneity and signaling networks in aortic dissection (AD) tissues compared to adjacent normal tissues. The analysis ide...

🔥Latest Article!
Single-cell analysis uncovers smooth muscle cell subtype switching as a key driver of fibrosis, inflammation, and vascular disruption in aortic dissection.
#AorticDissection #SingleCell #Vascular #Fibrosis
onlinelibrary.wiley.com/doi/10.1002/...

Chromatin unwinding state for in situ identification and lineage tracing of circulating tumor cells The detection of circulating tumor cells (CTCs) through liquid biopsy offers a non-invasive approach for accurately monitoring cancer dissemination and evaluating therapeutic efficiency. However, the...

🧬Chromatin unwinding state for in situ identification and lineage tracing of circulating tumor cells
⚙️ This attention-based model traces rare CTCs directly from blood without enrichment, supporting early detection and anti-metastatic strategies.
onlinelibrary.wiley.com/doi/10.1002/...

Targeting DGKα/PA axis inhibits tumor immune evasion and augments sensitivity to immunotherapy in gastrointestinal cancers Immune checkpoint inhibitors (ICIs) have shown promising antitumor efficacy in certain types of solid tumors. However, the efficacy of ICIs remains unsatisfactory owing to the dysregulation of signal...

The DGKα/PA axis drives immune evasion by activating NF-κB and upregulating PD-L1 in tumors.
⚙️ Inhibiting DGKα reduces PD-L1, enhances CTL infiltration, and improves ICI efficacy, with plasma PA as a potential biomarker in gastrointestinal cancers.
onlinelibrary.wiley.com/doi/10.1002/...

Chondroitin sulfate restores muscle mass via gut–muscle axis remodeling through sugar–bile acid metabolism reprogramming The graphical abstract illustrates the molecular mechanism by which chondroitin sulfate (DCS) alleviates glucocorticoid-induced myopathy through the gut–muscle axis. DCS selectively enriches L. johns...

💪Chondroitin sulfate restores muscle mass via gut–muscle axis remodeling through sugar–bile acid metabolism reprogramming
⚙️ Enrichment of Lactobacillus johnsonii and secondary bile acids activates PAX7/NMRK2 pathways, promoting muscle regeneration.
onlinelibrary.wiley.com/doi/10.1002/...

Microbial metabolites in tumor epigenetic regulation The gut microbiome modulates tumor epigenetic regulation through bioactive metabolites derived from dietary substrates. Microbiota-produced SCFAs, secondary BAs, one-carbon metabolites, and tryptopha...

🧐Microbial metabolites in tumor epigenetic regulation
The gut microbiome reshapes tumor epigenetics via metabolite signaling.Bile acids and tryptophan-derived ligands regulate HDAC/DNMT/AhR pathways, altering chromatin states and tumor behavior.
onlinelibrary.wiley.com/doi/10.1002/...

Spatial multi‐omics identifies a NOTCH3‐mediated capillary–mCAF crosstalk driving immune exclusion in hepatocellular carcinoma Spatial multi-omics defines a DLL4–NOTCH3–driven capillary–mCAF axis orchestrating fibrotic remodeling and immune exclusion in hepatocellular carcinoma tumor cores, conferring immune checkpoint block....

Spatial multi-omics identifies a NOTCH3-mediated capillary–mCAF crosstalk driving immune exclusion in hepatocellular carcinoma

Fibrosis-driven immune exclusion in HCC is linked to endothelial–CAF crosstalk…
onlinelibrary.wiley.com/doi/10.1002/...

A large‐scale single‐cell transcriptomic atlas indicates the immune panorama of influenza A infection The study presents a large-scale single-cell transcriptomic atlas profiling over 612,010 peripheral immune cells from 97 individuals to decode the heterogeneity of influenza infection. These findings...

👏A large-scale single-cell transcriptomic atlas indicates the immune panorama of influenza A infection
We generated a large-scale single-cell transcriptomic atlas from peripheral blood, profiling more than 612,010 cells from 97 individuals.
#HostResponse
onlinelibrary.wiley.com/doi/10.1002/...

Two stable gut microbiome guilds predict liver tumor class and treatment responses

⚙️ Functionally opposing microbial guilds highlight an ecological basis for tumor progression and clinical outcomes. #Hepatocellular
onlinelibrary.wiley.com/doi/10.1002/...

Sangerbox 2: Enhanced functionalities and update for a comprehensive clinical bioinformatics data analysis platform
onlinelibrary.wiley.com/doi/10.1002/...

STAGER checklist: Standardized testing and assessment guidelines for evaluating generative artificial intelligence reliability
onlinelibrary.wiley.com/doi/10.1002/...

USEARCH 12: Open-source software for sequencing analysis in bioinformatics and microbiome
onlinelibrary.wiley.com/doi/10.1002/...

iNAP 2.0: Harnessing metabolic complementarity in microbial network analysis
onlinelibrary.wiley.com/doi/10.1002/...

Duck gut metagenome reveals the microbiome signatures linked to intestinal regional, temporal development, and rearing condition
onlinelibrary.wiley.com/doi/10.1002/...

Specificity landscapes of 40 R2R3-MYBs reveal how paralogs target different cis-elements by homodimeric binding
onlinelibrary.wiley.com/doi/10.1002/...

Two telomere-to-telomere pig genome assemblies and pan-genome analyses provide insights into genomic structural landscape and genetic adaptations
onlinelibrary.wiley.com/doi/10.1002/...

The microbiome in cancer
onlinelibrary.wiley.com/doi/10.1002/...

HLF and PPARα axis regulates metabolic-associated fatty liver disease through extracellular vesicles derived from the intestinal microbiota
onlinelibrary.wiley.com/doi/10.1002/...

Gut microbiota-derived butyrate mediates the anticolitic effect of indigo supplementation through regulating CD4+ T cell differentiation
onlinelibrary.wiley.com/doi/10.1002/...

Age-specific reference intervals for plasma amino acids and their associations with nutrient intake in the Chinese pediatric population
onlinelibrary.wiley.com/doi/10.1002/...

RepliChrom: Interpretable machine learning predicts cancer-associated enhancer-promoter interactions using DNA replication timing
onlinelibrary.wiley.com/doi/10.1002/...

scRiskCell: A single-cell framework for quantifying islet risk cells and their adaptive dynamics in type 2 diabetes
onlinelibrary.wiley.com/doi/10.1002/...

Climate factors drive the local adaptation of Old World cattle
onlinelibrary.wiley.com/doi/10.1002/...

Construction of a clickable probe‐based protein chip platform for discovering covalent mIDH1 inhibitors from natural medicinal extracts In this study, we develop a flexible Ccc-Chip (protein microarray + bioorthogonal click chemistry) for high-throughput screening of natural covalent active molecules from medicinal plant extracts, id...

🌱 A clickable probe-based protein chip platform for discovering covalent mIDH1 inhibitors from natural medicinal extracts
onlinelibrary.wiley.com/doi/10.1002/...

Inhibition of ferroptosis by microbiota‐derived lithocholic acid underlies the intestinal radioprotection of a host defensin‐derived oligopeptide AT9(C/G), an oligopeptide derived from human defensin 5, enriches Bifidobacterium pseudolongum and increases lithocholic acid (LCA) levels in the intestine. Reduced levels of LCA link to increased se...

🤔A microbiota-targeted peptide shows promise for protecting the intestine from radiation injury.
Inhibition of ferroptosis by microbiota-derived lithocholic acid underlies the intestinal radioprotection of a host defensin-derived oligopeptide.
onlinelibrary.wiley.com/doi/10.1002/...

Oral proton‐reprogrammed nanomedicine to break the inflammatory bowel disease‐Clostridium difficile infection vicious cycle Research on the mechanism of OPR restoring intestinal epithelial cell (IEC) structure and function in inflammatory bowel disease (IBD) treatment. (A) Schematic diagram of OPR structure and the rate o...

Metabolic reprogramming of intestinal epithelial cells offers a new strategy for IBD–CDI treatment
💊 An oral proton-reprogrammed nanomedicine to break the inflammatory bowel disease-Clostridium difficile infection vicious cycle
@WileyHealth onlinelibrary.wiley.com/doi/10.1002/...

Curcuminoids amplify host innate antiviral immunity via the CRYAB‐RBM26 axis in viral infection DMC/CUR antagonize viral hijacking of host nucleic acid resources and finely regulate the induction and effector phases of the type I interferon (IFN-I) pathway through the CRYAB-RBM26 axis. This mol....

🌿Curcuminoids amplify host innate antiviral immunity via the CRYAB-RBM26 axis in viral infection
#VirusDefense #Curcuminoids #ScientificBreakthrough
onlinelibrary.wiley.com/doi/10.1002/...

Chromatin unwinding state for in situ identification and lineage tracing of circulating tumor cells The detection of circulating tumor cells (CTCs) through liquid biopsy offers a non-invasive approach for accurately monitoring cancer dissemination and evaluating therapeutic efficiency. However, the...

🚀 New breakthrough in cancer detection!
Chromatin unwinding state for in situ identification and lineage tracing of circulating tumor cells
#CancerResearch #LiquidBiopsy #PanCTC #CancerDetection #AIinMedicine
onlinelibrary.wiley.com/doi/10.1002/...

A bioactive ginsenoside alleviates hepatocellular ferroptosis induced by oxidized phospholipid accumulation in nonalcoholic steatohepatitis Schematic representation showing that 20 (S)-Rg3 improves mouse NASH. 20(S)-Rg3 reduces OxPLs levels and ameliorates ferroptosis in the liver of NASH mice. Mechanistically, 20(S)-Rg3 activates SPOP. ...

👏 Targeting ferroptosis in NASH

🧐 A bioactive ginsenoside alleviates hepatocellular ferroptosis induced by oxidized phospholipid accumulation in nonalcoholic steatohepatitise.
#NASH #Ferroptosis #LiverDisease #Metabolism
onlinelibrary.wiley.com/doi/10.1002/...

BIOME cohort: Multi‐system microbiome dynamics and clinical outcomes in massive burn injury patients Massive burn injuries (MBIs) are associated with high mortality and disability rates, primarily due to microbial-driven sepsis from extensive skin barrier loss and subsequent scar formation. This mak....

BIOME cohort: Multi-system microbiome dynamics and clinical outcomes in massive burn injury patients
🔥 A cohort to map microbiome dysbiosis after massive burn injury.
onlinelibrary.wiley.com/doi/10.1002/...

EasyMetagenome: A user-friendly and flexible pipeline for shotgun metagenomic analysis in microbiome research
onlinelibrary.wiley.com/doi/10.1002/...