And another upcoming event for our lab! - Chi-Jane's PhD defense on April 23, 1:30pm (Poster made by Luvna :) ) .

Luvna will be sharing her work on cross tissue immune cell coordination in ALS tomorrow from 10-11am in MEJ3116! 🧫🖥️

Evolving brain-immunity: From Ramón y Cajal’s mysterious butterflies to a garden sustained by immune cells as their nectar Over the last three decades, dogma-breaking studies have refuted the brain’s assumed immune isolation. Echoing Ramón y Cajal metaphor of neurons as “butterflies,” Schwartz proposes viewing the brain a...

Evolving brain-immunity: From Ramón y Cajal’s mysterious butterflies to a garden sustained by immune cells as their nectar: www.cell.com/neuron/fullt... 🦋💐 @cp-neuron.bsky.social

this is a nice discussion. I think the pressure to always innovate computationally actually slows down science when we already have a lot of great tools. The important and arguably hard part is to interpret what the output of these tools mean scientifically.

My new use for Gemini: I give it a bunch of information and ask it to write me code to make a nice infographic figure to plot in python and it is amazing !

My PhD student Chi-Jane is graduating soon and looking for her next position. She is an expert in CyTOF and IMC analysis, especially :) she can help you to derive predictive immune signatures from your data 💻🧫 check out her awesome website !! chencookie.github.io/index.html

Microglia protein profiles in CSF across Alzheimer’s disease clinical stages @nataging.nature.com
www.nature.com/articles/s43...

Persistent microglial activation following neonatal CMV infection mediates neurodegeneration www.science.org/doi/10.1126/...

Out of many, IL-1 Sick animals often show reduced social engagement, a form of adaptive behavioral distancing thought to limit pathogen transmission beyond the infected individual. In a recent issue of Cell, Yang et al...

@cp-immunity.bsky.social spotlight
Defined molecular and anatomical pathway through which inflammatory signals are sensed by the brain and translated into active social withdrawal
www.cell.com/immunity/ful...
on @cellcellpress.bsky.social
www.cell.com/cell/fulltex...

Multi-tissue transcriptomic aging atlas reveals predictive aging biomarkers in the killifish - Nature Aging Characterizing molecular aging features is crucial for understanding systemic and local factors contributing to the aging process. Here Costa, Chen et al. performed RNA sequencing on 13 tissues across...

Multi-organ transcriptomic aging atlas in killifish, with both males and females! 🐟🐟🐟

Huge congratulations to Emma, Jing, Tony and the entire team!! ✨⭐

@emkcosta.bsky.social
@jingxunchen.bsky.social
Wyss-Coray lab!

www.nature.com/articles/s43...

@biorxivpreprint.bsky.social Optimal transport fate mapping resolves T cell differentiation dynamics across tissues
www.biorxiv.org/content/10.6... @natstann.bsky.social

when it's your turn to give lab meeting and you don't have new results to show

"Cross-Organ Neuroimmunology of Behavior". Xuanming Guo and I discuss a new framework that reconceptualizes behavior as an emergent property of a distributed, brain-body neuroimmune network. lnkd.in/eihqZ_ay. @sinaiimmuno.bsky.social @sinaibrain.bsky.social

Immunity in Alzheimer’s disease: From mechanisms to therapies Alzheimer’s disease (AD) is driven by dynamic interactions between innate and adaptive immunity. Colonna, Chen, and Holtzman review recent advances in the genetic and mechanistic understanding of how microglia and T cells shape AD progression, and discuss how immunotherapeutic strategies must incorporate temporal and biological precision to modify neurodegeneration.

Online now: Immunity in Alzheimer’s disease: From mechanisms to therapies

Atlas-guided discovery of transcription factors for T cell programming - Nature A comprehensive atlas platform integrating transcriptional and epigenetic data enables more precise engineering of T cell states, accelerating the rational design of more effective cellular immunother...

New study—and exciting collaboration with Wei Wang, Cong Liu (UCSD), and Kay Chung (new lab at UNC)—that provides a platform for designing T cells into specific states. We identified state-selective TFs for CD8 T cell states that enable “recipes” for cell engineering! www.nature.com/articles/s41...

Antigen specificity of clonally enriched CD8+ T cells in multiple sclerosis - Nature Immunology Sabatino and colleagues examine expanded CD8+ T cell clonotypes from a small cohort of multiple sclerosis patients. They identified several cognate peptide epitopes that derive from Epstein–Barr virus...

Overjoyed to share our new work exploring the antigen specificity of CSF-expanded CD8+ T cells in #multiplesclerosis #EBV in @natimmunol.nature.com #immunology 🧪🧵1/

www.nature.com/articles/s41...

Sounds amazing! - am definitely going to give this a read.

Fun friend group

Targeting immune cells in the aged brain reveals that engineered cytokine IL-10 enhances neurogenesis and improves cognition Immune cells populate the old brain, but whether they can be specifically targeted to improve brain function in older individuals remains unclear. Navarro Negredo et al. dissect how aging impacts brain immune activity and show that targeting immune cells with an engineered IL-10 variant rebalances inflammatory programs in microglia, improves neurogenesis, and enhances cognition in old mice.

Online now: Targeting immune cells in the aged brain reveals that engineered cytokine IL-10 enhances neurogenesis and improves cognition

@biorxivpreprint.bsky.social The innate cytokine IL-18 inhibits CNS autoimmunity through preferential activation of protective CD8 T-cells @cannalab.bsky.social
www.biorxiv.org/content/10.6...

Our intellectual epicenter :)

Review @moltherapy.bsky.social
Redefining Multiple Sclerosis with CAR-T Cell Therapy
www.cell.com/molecular-th...

Review @natrevneuro.nature.com
Immune dysfunction in Alzheimer disease
www.nature.com/articles/s41...

Resolving the mysteries of brain clearance and immune surveillance: @cp-neuron.bsky.social www.cell.com/neuron/fullt...

@natimmunol.nature.com News & Views
Quiet custodians of CD8+ T cell fate
www.nature.com/articles/s41...
on
www.nature.com/articles/s41...
www.nature.com/articles/s41...

Meeting report @natimmunol.nature.com
Neuroimmune interactions in health and disease
www.nature.com/articles/s41...

NEW STUDY! Building on pioneering work by Dr. Alison Goate, an international team of researchers, led by #IcahnMountSinai's Anne Schaefer, ID'd distinct population of neuroprotective #Microglia that may point to new therapeutic approach for #Alzheimers. @nature.com 👉 www.nature.com/articles/s41...

Mickey Mouse Packing Struggles GIF ALT: Mickey Mouse Packing Struggles GIF

trying to fit a project timeline and a power calculation into a proposal when it is stuffed to the brim 😂