Cancer cells impair monocyte-mediated T cell stimulation to evade immunity - Nature Inflammatory monocytes are identified as important players in T cell restimulation in the tumour microenvironment.

Interested in inflammatory monocytes - check this outstanding piece from @obenaufa.bsky.social and team! Great study! www.nature.com/articles/s41...

Imagine your body as a coral reef where cancer causes pollution, but scientists found a way to remedy it.

@obenaufa.bsky.social @guillemxtivill.bsky.social @impvienna.bsky.social @natureportfolio.bsky.social

t.co/tySfh9MXSq
#ImmunoSky 🧪

Another masterpiece from our friends in the Obenauf lab, deciphering an entire cascade that enables cancer cells to evade immunity & discovering a key role of monocytes in T-cell activation! Huge congrats to @obenaufa.bsky.social, @aelewaut.bsky.social, @guillemxtivill.bsky.social & all co-authors!

New fundamental insights into the battle between immune cells & tumor cells: Anna @obenaufa.bsky.social's lab @impvienna.bsky.social discovered that T cells get stimulated in tumors by inflammatory monocytes, an activity blocked by oncogenic signalling through counter-regulation of PGE2 and IFN-I.

Dendritic cells maintain the CAR T cell pool in irradiated tumors
www.biorxiv.org/content/10.1...

Thank you Sakari for your kind words and for your support and expertise throughout the unfolding of this story!

Inflammatory monocytes can restimulate T cells in tumors, and cancer cell-induced disruption of this process can lead to tumor immune evasion. Details 👇 in the wonderful 🧵 by @obenaufa.bsky.social and the paper published today @Nature. What a privilege it has been to be part of this amazing team!

Cancer cells impair monocyte-mediated T cell stimulation to evade immunity - Nature Inflammatory monocytes are identified as important players in T cell restimulation in the tumour microenvironment.

New publication by @aelewaut.bsky.social & @guillemxtivill.bsky.social from @obenaufa.bsky.social lab about cancer-mediated immune evasion – very interesting!

#HemeSky #OncoSky

www.nature.com/articles/s41...

🚨very elegant study alert 🚨

Congratulations #ObenaufLab on this amazing study of how MAPK-induced PGE2 secretion induces tumor immunosuppression. Impressive work!

🧪Cross-Dressing intratumoral monocytes fulfill the job of cDC1s in supporting tumor-infiltrating CD8 T cells in their anti-cancer functions. Great to have contributed some 🔬&🧫 to this tour de force study by @obenaufa.bsky.social

Cancer cells impair monocyte-mediated T cell stimulation to evade immunity - Nature Inflammatory monocytes are identified as important players in T cell restimulation in the tumour microenvironment.

#InterferonPower! Elewaut, @obenaufa.bsky.social &co show @ Nature that inflammatory monocytes can acquire MHC-class I from tumor cells & locally activate CD8 T cells, given that the capacity of the tumor to shut down type I #IFNs & upreg PGE2 is reverted! www.nature.com/articles/s41...

Cancer cells impair monocyte-mediated T cell stimulation to evade immunity - Nature Inflammatory monocytes are identified as important players in T cell restimulation in the tumour microenvironment.

new out in Nature www.nature.com/articles/s41... Cancer cells impair monocyte-mediated T cell stimulation to evade immunity

Cancer cells blunt monocyte IFN while increasing PGE2 to inhibit T cell immunity @obenaufa.bsky.social @aelewaut.bsky.social @guillemxtivill.bsky.social
www.nature.com/articles/s41...

Our Paper out in @natureportfolio.bsky.social with correct link www.nature.com/articles/s41...

Super excited to see this out! @aelewaut.bsky.social taught me everything I know about “real” cancer immunotherapy research from injecting mice to flow cytometry 🐁Congratulations @guillemxtivill.bsky.social @obenaufa.bsky.social and the Obenauf Lab!

That was a really fun and fruitful collaboration, we learned so much from each other! Thanks again ☺️

Extremely excited to see my PhD work in the @obenaufa.bsky.social published today in @natureportfolio.bsky.social 🤩. A big thank you to everyone who contributed, special thank you to my partner in crime @guillemxtivill.bsky.social - it was a lot of fun to work on this together! 🥳

#Immunotherapy has transformed #cancer treatment, but some cancers evade immune defenses, causing resistance.

@obenaufa.bsky.social's lab has discovered how inflammatory monocytes—a type of immune cell—can reactivate cancer-killing T cells within tumors.

Read more: imp.ac.at/news/article...

Thank you @johannajoyce.bsky.social!!! Very excited that it is finally coming out! Very much looking forward to the reactionsand comments across the myeloid and immunotherapy fields!