We hope this work provides a useful reference for future studies of cortical signalling and calcium homeostasis, and helps guide research into conditions such as seizures, inflammation, and epilepsy. Grateful to all collaborators, facilities, and team members who contributed to this work.

These findings help clarify a long-standing debate in the field regarding TRPA1 and TRPV1 expression in the cortex, particularly because antibody-based approaches alone can be difficult to interpret where non-specific signals and cross-reactivity remain important concerns.

In our new study, we explored how TRP channels are represented in the adult mouse cortex 🐭🧠. This has remained difficult to define clearly because many TRP channels are highly hydrophobic membrane proteins and are challenging to detect reliably, especially at low abundance.

Ever wondered why chili peppers feel hot 🌶️🫑? That sensation comes from TRP channels — a remarkable family of ion channels involved in sensing temperature, touch, and chemical stimuli, and central to discoveries recognised by the 2021 Nobel Prize in Physiology or Medicine.

Excited to share that our latest manuscript is out today on bioRxiv:
"Integrated transcriptomics and proteomics define the TRP channel hierarchy in mouse cortex"

biorxiv.org/content/10.6...

@ouranu

#TRP #TRPA1 #TRPV1 #Epilepsy #Mouse #Brain #Cortex #Calcium #JCSMR #ANU

Study finds mice perform ‘First Aid’ upon activation of neurons in the amygdala and oxytocin-expressing neurons!

science.org/doi/10.1126/sc…

#firstaid #cpr #mice #behaviour

RNA molecule rejuvenates ageing mice by restoring old cells Mice injected with a microRNA molecule lived longer and had fewer markers of ageing, but it’s not yet known if the treatment would work in people.

Injecting RNA molecules into old mice reverses signs of aging, extends lifespan, regrows hair, and preserves physical and mental abilities.

#aging #rna

www.nature.com/articles/d41...

Suppression of epileptic seizures by transcranial activation of K+-selective channelrhodopsin - Nature Communications Optogenetic tools allowing transcranial neural inhibition in treating seizures are limited. This study demonstrates that noninvasive transcranial optogenetic activation of a highly sensitive K + -cond...

Suppression of epileptic seizures by transcranial activation of K+-selective channelrhodopsin
#optogenetics #epilepsy #seizure

www.nature.com/articles/s41...

Tasmania’s glowing coastline, Australia 🇦🇺

#bioluminescence

Ageing limits stemness and tumorigenesis by reprogramming iron homeostasis - Nature Studies using mouse models of lung adenocarcinoma identify an association between age, iron homeostasis and tumour initiation potential that involves NUPR1 and lipocalin-2.

🧪🕰️ Why Cancer Risk Drops After 80

As we age, stem cells lose their ability to grow–including cancerous growth. A new study links this to older cells acting like they lack iron

Targeting this process might improve lung health & cancer therapies

🔗 www.nature.com/articles/s41...

#Health #SciComm 🧪

Autofluorescence in the face of a little two-spotted ladybird by fluorescence lifetime imaging microscopy (FLIM) 🐞

Image: Centre for Advanced Microscopy, ANU

#nikkon #small #world #fluorescence #imaging

One of the most fascinating approaches I have found is decoding brain activity in a paralyzed person. Take a look at the video link below:

www.youtube.com/embed/vL7yMn...

Why I shouldn’t present it in Journal Club! Interesting approach ✨

Can optogenetics be used to control activity in human brain tissue?

nature.com/articles/s4159…

World's first use of corneal epithelial cell sheets derived from human induced pluripotent stem cells (iPSCs) to treat limbal stem-cell deficiency (LSCD)

Stem cells and Optogenetics are surprising like AI! 

thelancet.com/journals/lance…

#stem #cell #optogenetics #therapy #ai