📰New & Featured | November New Releases
🚀1,000+ New Bioactive Molecules, targeting #WEE1 #HPK1 #MDM2 #TRPA1 #PARK7 #GLP1R
✔Reduce trial-and-error in early discovery
✔Access phase-advanced, high-selectivity research tools
#Oncology #Neuroscience #DrugDiscovery #ResearchTools

🔥Hot Off the Press | 🧠 New in #Cell: During recovery from illness, the gut tells the brain to avoid #protein.
Amino acids (#glutamine, #lysine, #threonine) trigger gut #TRPA1 receptors → #serotonin release → brainstem → #protein aversion.
⚙️A defense against #ammonia toxicity.
#AminoAcids #gut-brain

Calmodulin Found to Regulate Pain-Triggering TRPA1 Channel

Yale researchers showed calmodulin binds a newly identified site on the TRPA1 ion channel, forcing it closed and halting pain signaling, per a Nature Communications study. getnews.me/calmodulin-found-to-regu... #calmodulin #trpa1 #chronicpain

🎉 TRPA1-derful news 🎉 Dr. Dan Conklin has been successful in obtaining AHA funding to explore how inhaled anesthetics affect cardiorespiratory function through Transient Receptor Potential Ankyrin-1 (TRPA1). #AHA #TeamConklin #TRPA1 #cardiosky @ahascience.bsky.social @uoflenvirome.bsky.social

Propofol reduces human TRPA1 activity in a warm environment - PubMed Propofol, an intravenous anesthetic, has a side effect of causing vascular pain at the injection site. However, no effective method to inhibit this vascular pain has been established. Propofol-induced...

#Propofol, a popular anesthetic, causes vascular pain due to activation of #TRPA1 sensory irritant receptor. A new study shows temperature dependence for this TRPA1 activation by propofol.
(Warm up your propofol >35C before injection)
pubmed.ncbi.nlm.nih.gov/39963338/

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"Human TRPA1 activity is suppressed by caffeine (Figure 10), whereas in mice this ion channel is stimulated by caffeine."

doi.org/10.1177/0960...

#MouseVsHuman #MouseModel #Mice #TRPA1 #TRPchannels #caffeine #pain #neuroscience #biology

ポーラ化成が発見した夏の日焼け対策、TRPA1とナトリウムの関係 ポーラ化成工業が、日焼けの原因となるメラニン生成のメカニズムを解明。TRPA1の役割や新たなエキスによる対策を紹介します。

ポーラ化成が発見した夏の日焼け対策、TRPA1とナトリウムの関係 #ポーラ化成工業 #メラニン #TRPA1

ポーラ化成工業が発見した日焼けメカニズムとその対策について ポーラ化成工業が、体内イオン環境と日焼けの関係を発見。メラノサイトのTRPA1が「すぐヤケ」を引き起こすメカニズムを解明し、効果的な対策を提案。

ポーラ化成工業が発見した日焼けメカニズムとその対策について #神奈川県 #横浜市 #ポーラ #TRPA1 #メラノサイト

ポーラ化成工業が、体内イオン環境と日焼けの関係を発見。メラノサイトのTRPA1が「すぐヤケ」を引き起こすメカニズムを解明し、効果的な対策を提案。

Wow, I feel so outdone by this, the movement in the PIEZO is inspired!
But in a similar vein, here is my #ScienceTattoo; a floral interpretation of a figure from a project I spent 8 years working on!
So a little backstory on why this bit of TRPA1 🧵
1/
#Scicomm #neuroscience #sensoryNerves #TRPA1