New scientific publication by the group of Thomas Gorochowski on DNA synthesis

Work emerged from discussions with the wonderfully creative @adrianwoolfson.bsky.social and Andrew Hessel, with Sim and Thea doing the heavy lifting in the lab. Would love to build a team to take this towards programmable DNA printers and I'm sure doodling plays an interesting role in evolution!

🧬Want to synthesise kilobase-scale DNA? We got you covered!🥳 In latest from the lab we explore the "doodling" capabilities of DNA polymerases and ways to guide the sequences produced. Loads of data + beautiful AFM of the molecules themselves. #synbio ... doi.org/10.1038/s414...

Analysis and control of untemplated DNA polymerase activity for guided synthesis of kilobase-scale DNA sequences
doi.org/10.1038/s414...

New on @biorxiv!!!!!!
We’re excited to share our latest paper on combining cell-free systems and machine learning to express full genome in vitro.

Check it out now! 👉 www.biorxiv.org/content/10.1...

Catch us at SEED in Houston this June to discuss this work.
#CellFree

Faculty position in Plant Molecular Biology (Associate Professor or Tenure-Track Assistant Professor) at Aarhus University, Denmark
mbg.au.dk/aktuelt/ledi...

The Immense Power Of Combining AI With Engineered Biology | Thomas Gorochowski #0037 YouTube video by Curious with Ezra Chapman

A fun (and mostly coherent!) discussion with Ezra Chapman on the intersection of AI and engineering biology. We live in such exciting times and I hope some of that excitement came across. Thanks Ezra for the invite. #engbio #synbio #ai
www.youtube.com/watch?v=SC4X...

Many microorganisms modify their movement in response to light. This new #JRSocInterface paper has developed an integrated pipeline capable of acquiring temporal imaging data and extracting kinematics to create digital twins: doi.org/10.1098/rsif... @chofski.bsky.social

🫣 Now for something a little different from the lab: a data-centric approach to building digital twins as a route to control of emergent population level behaviours in microbial swarms 🤔 If that means nothing to you, then just check out the video! doi.org/10.1098/rsif... #engbio #control

Next in Lab's conference agenda: AI, Engineering Biology and beyond. It starts today in Bristol hosted by @chofski.bsky.social. Looks great: aiebab.github.io. From our side, @lewisgrozinger.bsky.social will be talking about our approach to the use of evolutionary algorithms for biocomputation.

So happy you could come!

In Bristol for the week for the AI, Engineering Biology and Beyond conference hosted by @chofski.bsky.social. Very excited to meet the UK synthbio community. First day hackathon event was a blast!

It's so cute! All credit to Shiv the lead author for devising the name.

Cold and "nippy" 🥶 start to the #AIEBaB26 Hack-a-thon 💻. The students helping with the organisation have done an amazing job in pulling this all together. A big thank you to the @jgibristol.bsky.social and @aibio-uk.bsky.social for the support!

If you work with R6K plasmids for transient DNA delivery, our latest SHARK strains might be of use! Work out at ACS Synthetic Biology led by Shivang Joshi and strains plus plasmids for their assembly will be available @addgene.bsky.social very soon! doi.org/10.1021/acss...

If you are looking to integrate your latest genetic creation into the genome of your favourite bug, you might find our latest review now out in OUP Synthetic Biology useful. 🧬⚒️ Work led by Riesa Rohmat with input from Thea Irvine and Shivang Joshi. #genome #synbio doi.org/10.1093/synb...

Quantitative profiling of millions of nucleotides reveals sequence-encoded interactions that govern plasmid propagation Plasmids are central to modern biotechnology, especially therapeutic development, yet their propagation in Escherichia coli remains difficult to predict. Although expression-induced burden is well und...

So you think your mammalian plasmids have nothing to fear from cloning and propagation in E.coli?
Quantitative profiling of millions of nucleotides by Tom Copeman will prove you wrong! Supervised with the amazing @proftomellis.bsky.social and AZ, now on BioRxiv:
doi.org/10.64898/202...

Emerging trends in genome integration tools for precision engineering of diverse bacterial species Abstract. The ability to precisely insert DNA payloads into a genome enables the comprehensive engineering of cellular phenotypes and the creation of new b

Emerging trends in genome integration tools for precision engineering of diverse bacterial species
doi.org/10.1093/synb...

🚨 Last call for the 'AI, Engineering Biology and Beyond' conference taking place in Bristol on the 15-16 January 2026. There is a limited capacity and some places are still left, but worth signing up soon before the 19th December deadline! Register at: aiebab.github.io

📕My review for Jane Calvert's latest book, 'A Place for Science and Technology Studies' is out in Interdisciplinary Science Reviews! I really enjoyed the stories and learnt so mcuh. Well worth a read if you are interested in the ways that that study of science works: doi.org/10.1177/0308...

End of year Science Bonanza is always something I look forward to, not only for hearing about what the team has been up to all year, but also for the amazing food everyone brings. Christmas has started proper now 🎅

😍

Only available to UK applicants, and did I mention these studentships are part of the TechExpert pilot providing an enhanced annual (tax-free) stipend of £31,000. Do something amazing, and get paid for it!

Optimising a platform for RNA delivery in plants (Plant BioDesign Bristol project) at University of York on FindAPhD.com PhD Project - Optimising a platform for RNA delivery in plants (Plant BioDesign Bristol project) at University of York, listed on FindAPhD.com

(PhD 2) Join Heather Whitney, me and others to take plant RNA synthetic biology to a new level. Create new biofacbrication processes to enable the robust and effective RNA delivery to turbo-charge agriculture. 3/4 www.findaphd.com/phds/project...

SynProm: Fast, Modular Spatio-Temporal Transcriptional Reporters for Plants (Plant BioDesign Bristol project) at University of York on FindAPhD.com PhD Project - SynProm: Fast, Modular Spatio-Temporal Transcriptional Reporters for Plants (Plant BioDesign Bristol project) at University of York, listed on FindAPhD.com

(PhD 1) Join @PierreBuscaill and me to create SynProm, a modular synthetic biology toolkit for rapid, spatio-temporal monitoring of plant gene activity. Design, test & model synthetic promoters in Nicotiana benthamiana with a focus on plant immunity. 2/4 www.findaphd.com/phds/project...

A couple new #PhD opportunities to join my lab at the intersection of #synbio, #plantsci and #biotech as part of the Plant BioDesign doctoral programme spanning the University of York, University of Cambridge, University of Bristol and John Innes Centre. 1/4

Very excited for this project with @pierrebuscaill.bsky.social! Will bring together a lot of exciting tools we have up and running in the lab for working with diverse biology and put them to use in building new technologies to trace gene expression across plants. 🧬 🔍 Applications open!

The initial lineup of keynotes and spotlight talks is finalised, with 10 contributed talks still up for grabs! Come join us in Bristol on 15-16 Jan 2026 for AI, Engineering Biology and Beyond to shape the future of these fields🤖🧬🦠Register now at: aiebab.github.io

🚨Interested in the intersection of AI and Engineering Biology? 🤖🧬 If so, come join us in Bristol, UK from 15-16 Jan 2026 for the latest instalment of the "AI, Engineering Biology and Beyond" conference! It's going to be a "banger" and registration is open NOW! #synbio #ai aiebab.github.io

Université Grenoble Alpes opens a full professorship in microbiology in 2026. The selected candidate will develop their research program on quantitative approaches in microbiology in the Laboratoire Interdisciplinaire de Physique. More info: liphy.univ-grenoble-alpes.fr/en/join-us/r...