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Posts by Tim Sheahan

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Home - HCV-FLAVI 2026 Days Hours Minutes Seconds Program Registration Abstracts Organizing Committee Social Events Welcome to HCV-Flavi 2026 We warmly invite you to join the 32nd International Symposium on Hepatitis C Viru...

Interesting #flavivirus meeting alert hcv-flavi2026.org @leendelang.bsky.social @msdiamondlab.bsky.social #hcv #virology #viruses

1 day ago 0 0 0 0
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NIH grant terminations affected women scientists more than men, study finds A new paper shows that women, particularly those early in their careers, have been disproportionately affected by NIH grant terminations.

A new paper shows that women, particularly those early in their careers, have been disproportionately affected by NIH grant terminations. www.statnews.com/2026/03/23/n...

4 weeks ago 31 26 1 6

Modeling liver cancer caused by chronic hepacivirus infection. Great collab with Rice Lab
@rockefeller.edu
heavy lift by Mariana Batista #HCV #HCC #livercancer #cancer #chronicinfection
doi.org/10.1016/j.jh...

1 month ago 2 0 0 0
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Better half worked on the approval of J&J #icotrokinra. Happy birthday to Icotyde! My 11 year old made this card! #psoriasis #medicine #drugs #chemistry #IL23

1 month ago 5 1 0 0
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Hiked up to the “Big C” at @ucberkeleyofficial.bsky.social via Cyclotron road. My particles were accelerated once I got to the top #physics #crystalography #biology

2 months ago 2 0 0 0
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Loss of nsp14-exonuclease activity impairs the replication, proofreading, fitness and pathogenesis of SARS-CoV-2 Coronaviruses (CoVs) replicate their RNA genomes with increased fidelity than other RNA viruses, a mechanism mediated by the proofreading and recombination activities of the exoribonuclease domain of ...

Our new preprint on #SARSCoV2 nsp14 #exonuclease function in replication fidelity and fitness. ExoN- viruses are attenuated in vitro and in vivo but w/o #interferon signaling replication is largely restored! Suggests nsp14 plays a role in innate antagonism in vivo www.biorxiv.org/content/10.6...

3 months ago 11 3 0 0
Client Challenge

Human coronavirus 229E antibodies and Spike structure function paper is finally out for real. Led by @wrapplab.bsky.social (wrappers delight) and @mlicc1701.bsky.social (MFL) #lovevirology #229E #antibodies www.nature.com/articles/s42...

3 months ago 10 3 1 1

Did you mean to write “Jean Lim”?

4 months ago 1 0 0 0
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Mouse-adapted SARS-CoV-2 Omicron BA.5 infection induces post-acute lung fibrosis in BALB/c mice | Journal of Virology To best combat the evolving landscape of SARS-CoV-2 variants of interest and variants of concern, the development of effective small animal models is of critical importance. Herein, we describe the de...

New #coronavirus #postacute lung pathogenesis paper from my friend Dr. John Powers is up at @asm.org JVI. journals.asm.org/doi/10.1128/... Confusing as to why this link shows a rotund blue bird. #PASC #SARSCoV2 #Omicron #LoveVirology #JVI #ASM #virology

5 months ago 8 4 1 0
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Grant writing w ballet rehearsal on the side. #coronavirus #exonuclease is cool shit. Guides replication fidelity and we think masterminds control of the host response. Oh my. If only my 12 pages were done? #grantwriting #acadreamia #nih #coronavirus

10 months ago 4 0 0 0

MERBelous? I’m SARSy for the bad jokes.

10 months ago 0 0 0 0
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ACE2 from Pipistrellus abramus bats is a receptor for HKU5 coronaviruses - Nature Communications This work shows that receptor use in merbecovirus is clade-specific by clustering them into clades based on the receptor-binding domain (RBD) of their spike proteins. While MERS-CoV and its close rela...

New paper about ACE2 using Merbecovirus. Hot stuff. So hot but you can't Letko. @fviromics.bsky.social and Nick Catanzaro. www.nature.com/articles/s41... #ACE2 #emergingviruses #bats #batman #MERS #HKU5

10 months ago 10 8 1 0
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@mattfrieman.bsky.social taped this to my lab notebook almost 20 years ago. It’s not untrue 🤣Vestiges of simpler times. #lovevirology #virology #lablife #sars #laboratory #science #biology #academia

11 months ago 4 0 1 0

So nice to be teamed up with @wrapplab.bsky.social on this mAb project! It's been a delight. Some may say a Wrapper's Delight? #antibodies #virology #lovevirology #229E #coronavirus #therapeutics #vaccination #emergingviruses

11 months ago 7 0 0 0
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Having a hard time processing this. HHMI is pausing all competitions. Very demoralizing for early career scientists like me @hhmi.org

11 months ago 193 73 7 28
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NIH grant terminations under Trump have totaled at least $1.8 billion, analysis finds Researchers calculated that $1.8 billion in National Institutes of Health grants were terminated in just over one month

How much federal research funding has been axed so far in the new administration? An early estimate is $1.8B, but that's likely an underestimate, @aniloza.bsky.social reports. www.statnews.com/2025/05/08/t...

11 months ago 63 28 1 2
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Exclusive: NIH to suspend funds for research abroad as it overhauls policy Move by US biomedical agency threatens thousands of projects on infectious diseases, cancer and more.

www.nature.com/articles/d41...

11 months ago 0 1 0 0

One of the many things I lack…

1 year ago 1 0 0 0
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How does one determine EC50 w a curve like this? #antivirals #coronavirus #cell www.sciencedirect.com/science/arti...

1 year ago 4 0 1 0

Thank you @holdenthorp.bsky.social for being a voice which eventually we can hopefully build into a chorus. It's hard to not fall into a daily bleakness black hole (DBBH).

1 year ago 0 0 0 0
NOT-OD-25-080: Rescission of the Final Scientific Integrity Policy of the National Institutes of Health NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Rescission of the Final Scientific Integrity Policy of the National Institutes of Health NOT-OD-25-080. OD

NIH has rescinded its scientific integrity policy. Hard to see this as anything other than clearing the way for shoddy research on things like vaccines. Regardless of the rationale, it's bad news for public health.

grants.nih.gov/grants/guide...

1 year ago 3711 1474 119 167
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H.H.S. Scraps Studies of Vaccines and Treatments for Future Pandemics (Gift Article) Federal officials cited the end of the Covid-19 pandemic in halting the research. But much of the work was focused on preventing outbreaks of other pathogens.

"Angry, disappointed, frustrated"--Scientists were making progress on vaccines and antivirals for the next pandemic--until this week, when the Trump administration abruptly told them to stop. Here's my story with @apoorvanyt.bsky.social Gift link: nyti.ms/43Xz77q

1 year ago 1301 725 60 65

The damage being done to the biomedical community will probably not be appreciated for years

1 year ago 6 4 0 0
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Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses in vitro and in vivo.

FYI @veeslerlab.bsky.social We showed remdesivir worked against HKU5 in the paper linked below. Nice you have confirmed this! www.science.org/doi/10.1126/...

1 year ago 1 0 0 0
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Federal Register hold makes ‘end run’ around court pause on NIH funding freeze NIH-related updates to the Federal Register, which are required for the scheduling of study sections and advisory councils, are on hold indefinitely, according to an email reviewed by <i>The Transmitt...

I just covered this for @thetransmitter.bsky.social — will keep following! www.thetransmitter.org/funding/fede...

1 year ago 134 94 3 25
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Dysregulation of lung epithelial cell homeostasis and immunity contributes to Middle East respiratory syndrome coronavirus disease severity | mSphere Emerging coronaviruses like SARS-CoV, SARS-CoV-2, and MERS-CoV cause a range of disease outcomes in humans from an asymptomatic, moderate, and severe respiratory disease that can progress to death but...

Saved from death in the paper grave yard! Started in 2016. MERS-CoV infects epithelial cells, they die, pathology is wicked bad. Adaptive immune cells both control replication and drive pathogenesis. #coronavirus #MERSCoV #pathogenesis #LoveVirology #viruses #virus journals.asm.org/eprint/ZZEIT...

1 year ago 4 4 0 0
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Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring Researchers facing

Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring www.science.org/content/arti...

1 year ago 318 131 17 11
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“Rob” is now transcribed as “Ellen”?

1 year ago 1 0 0 0

When was the last MHV pandemic?

1 year ago 3 1 1 0