I am so excited to share our new findings with you! We provide the structural evidence for a direct protein-to-DNA information pathway, showing how a bacterial enzyme 'reads' its own structure to 'write' DNA. www.science.org/doi/10.1126/...
HDRisée ! Merci pour cette belle discussion 🦇 / HDR done! Thanks all, especially my team, collaborators and my jury for this really stimulating discussion! After these tough months, it was really comforting to put together this kind of talk and the team's newest results
We won't get anywhere if we don't change this, at least, we won't be able to keep up internationally.
Having an established model system and prelim results is key. And you don't get that without steady funding. Even now, even heavily amputated, the amount of US funding is still magnitude above what we can get or even apply for in France. Not trying to blame anyone, just stating facts, sadly.
I was still in the states when I wrote my CoG, and I had UCL (UK) as the host institution which gave me great support while preparing the written application. I am not sure I would have gotten the same thing in France nor the same amount of prelim results (I was funded by NSF in the US)
Do you want to know how to build an organ from a single cell?
Check out our paper about phyllid development in moss by Weney Lin @irbv.bsky.social
Colaboration with Yoan Couder @ensdelyon.bsky.social and and Richard Smith @johninnescentre.bsky.social
www.science.org/doi/10.1126/...
And the truth is, even when you get one, you do not get the necessary support to carry your work, even in basic conditions. You even waste this precious money due to institutional failure. It's so demoralizing.
With all the cuts to research funding in European countries, everyone is turning to the ERC...
The ERC should be a source of supplementary funding, not a substitute.
Every country in Europe must invest in basic research and increase its budgets!!!!
I don’t know if you saw the MASSIVE news announced by @erc.europa.eu today: from now on, if you get a B at step 1 you are eligible to apply at N+3(!!!) years. Say you got a B in STG2026 step 1, you thought you could apply in STG2028, but no: only in STG2029! erc.europa.eu/news-events/...
Maternal nutrient sensing regulates ribosome provisioning to the next generation. Maternal dietary restriction and reduced mTORC1 signaling in the pharynx through the Rag GTPase RAGA-1 regulate the amount of translational capacity deposited into embryos. As a result, progeny of dietarily restricted mothers inherit reduced levels of ribosomal proteins at hatching. Although embryogenesis proceeds normally, larvae begin life with lower translational capacity, leading to smaller size and slower early growth until ribosome levels recover during larval development. The diagram was generated in BioRender.
Animals adjust their #proteome to match the environment, but can the proteome can be propagated #transgenerationally? Elif Cenik explores a @plosbiology.org study showing that maternal nutrient sensing regulates ribosome deposition into embryos. Paper: plos.io/4tMpQJe Primer: plos.io/41qOzGT
Would you like to learn about ✨ #Nudibranch 🐌 🌊 regeneration✨ and the evolution of ✨ ✨ #musculoskeletal 🍖 development in avian models 🐣 ✨ ✨ ? Join us this next Monday 1pm ET for our first @evodevopanam.bsky.social #EvoDevoMondays! It’s open to all registrants 🩷. Link 🔗 👇
Paper alert! 📣
Really cool study stemming from the Master thesis of #Benjamin_Zelvelder @cbgpmontpellier.bsky.social @inrae-dpt-spe.bsky.social with @remiallio.bsky.social
#insect host-shifts between #parasitic and non-parasitic plants!
#Proc.B @royalsocietypublishing.org
doi.org/10.1098/rspb...
C'est le constat édifiant mené sur 13 000 scientifiques danois. En retraçant leurs carrières sur plus de 20 ans, cette nouvelle étude révèle qu'un tiers des femmes devenues mères quittent la recherche. Un effet absent chez les hommes et qui pourrait expliquer le phénomène du "tuyau percé".
GBE | Cosmopolitan Gene Families With Known Functions Are Hotspots for the Evolution of Novel Genes in Stony Corals Photos: Erin Chille / Debashish Bhattacharya
Stephens, Kulczyk & @bhattacharyalab.bsky.social suggest that dark genes (those with no ascribable biological function) in stony corals originated via bursts of lineage-specific duplication, often from genes with known functions.
🔗 doi.org/10.1093/gbe/evag072
#genome #evolution #corals
"Ça devient vraiment critique": les laboratoires du CNRS bientôt contraints d'arrêter leurs travaux faute de crédits ?"
www.larep.fr/orleans-4500...
With this “Behind the paper” story, I’d like to give special thanks to two remarkable contributors whose generosity made a big difference:
@jialinliu.bsky.social for the scMultiomics data behind the multiomic atlas,
and Guoqiang Yu’s group for sharing ITEC cell tracking, which enabled MERFISH-FATE.
Rappel: En 2023 le CIR représentait 7,8 milliards d'€ d'argent public...quasi le double du budget cumulé du CNRS, de l'INSERM & de l'INRAE.
L'État subventionne plus la recherche privée que ses propres organismes scientifiques. C'est Moche.
blogs.mediapart.fr/hendrik-davi...
@hendrikdavi.bsky.social
Hi all. I am very excited that after 6 years I finally got my phylogenetic comparative methods book and online exercises online. Feel free to use and share. The book is here: nhcooper123.github.io/pcm-primer/. Note that it is not finished, we had to abandon it before the sunk costs fallacy broke us
PASEDB community 🤩
We are excited to announce our first Research Webinar series called:
⭐️EvoDevo Mondays⭐️
Save the date - April 13
With our amazing speakers @luiza-o-saad.bsky.social and João Francisco Botelho
Session chair Professor Natalia Pabón-Mora
#PASEDB #EvoDevoMondays #EvoDevo
How does development shape the variation evolution can act on?
In our new paper in @pnas.org , we bridge developmental dynamics and quantitative genetics, linking dynamical models of phenotype formation with the statistical parameters used to study evolutionary change
www.pnas.org/doi/10.1073/...
Download our large database of postdoc fellowships in all fields of research.
Database freely available to all; 281 fellowships.
Download here: research.jhu.edu/rdt/funding-...
Very happy to see this out. 👏 @yinanwan.bsky.social
Bogdan Bintu and team.
Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis | free link Science www.science.org/eprint/5MHTM...
I wrote a short Nature Methods News & Views piece on deep learning based gene finders such as ANNEVO. www.nature.com/articles/s41...
In animals with large genomes, finding cis-regulatory elements can be very challenging. Enhancers can be located tens/hundreds of kb away from their target promoters. We face this challenge in Parhyale, with >3 Gbp genome.
We just published a preprint describing how we are tackling this problem. /1
First 24 hours of embryonic development in 9 different animal species: (From left to right) Zebrafish, Sea urchin, Black widow spider, Tardigrade, Sea squirt, Comb jelly, Parchment tube worm, Roundworm, Slipper snail. Credit to @tessamontague.bsky.social & Zuzka Vavrušová. #ZebrafishZunday #devbio 🧪
A two-column status table titled "Stage" and "Start Date" tracks the timeline of a manuscript submission from its preliminary data submission on October 8, 2025, to its eventual withdrawal on March 2, 2026. The log reveals a lengthy and repetitive administrative process, particularly between October 26, 2025, and February 19, 2026, where the status cycled more than ten times between "Contacting Potential Reviewers" and "Waiting for Reviewer Assignment," suggesting significant difficulty in securing peer reviewers. Following these numerous failed attempts to move into the active review phase, the final entry shows the manuscript was officially withdrawn on March 2, 2026, at 09:08:18.
My first paper had to be mailed to Stockholm, Sweden, and then mailed to reviewers around the world. Everything by mail! It was submitted, reviewed, revised, typeset, and published in 3 months. I feel bad for early-career scientists who can't find a single reviewer after 5 months. It's gotta change.
I’m sure today’s theme will be filled with incredible moon shots…but this one will always be my favorite I’ve ever taken.
Right as I pressed the shutter, a bat flew straight through the frame — turning a simple moon photo into a cool moment. #BlueSkyArtShow #Round #BlueSkyPhotography #Night
The growing number of sequenced #genomes provides a positive feedback loop, in which database searches become more effective and shared sequence patterns emerge more clearly www.nature.com/articles/s41... #biodiversity #genomics
We wrote a perspective "How to build the regulatory genome: a constructionist guide to the cis-regulatory code", out in Development yesterday. Title says it all. Find it here:
journals.biologists.com/dev/article/...
New pre-print with some updates on ivory:miR193 in a highly polymorphic moth.
www.biorxiv.org/content/10.6...
We mapped ivory (again!?) this time controlling aspects of camouflage in Anticarsia gemmatalis. Mapping, SVs, Expression and Function.
Comments/suggestions welcome!
