FANTASIA leverages language models to decode the functional dark proteome across the animal tree of life - Communications Biology FANTASIA, a protein language model-based tool, enables large-scale functional annotation across ~1000 animal proteomes, revealing novel gene functions in both model and non-model organisms beyond…

#ERGAReads | FANTASIA leverages language models to decode the functional dark proteome across the animal tree of life
www.nature.com/articles/s42...

@rosafernandez.bsky.social @commsbio.nature.com @csic.es @ibe-barcelona.bsky.social

#LLM #proteome #functional #annotation #genomes

✨Cluster 'Small Molecules in Medicinal Chemistry'✨

Unlock the #proteome with succinimide-containing probes🧪 Developed by William Parsons & co-workers, these new reactive groups are expanding how we study #enzyme activity

#OpenAccess 👉 www.thieme-connect.com/products/ejo...

Iterative Mapping is our novel method for single-molecule proteomic analysis. Watch our latest animation for a brief look at how we use Iterative Mapping to quantify proteins and proteoforms on the Nautilus Platform.

youtu.be/6X2UeTiJNh8

#Proteomics #Proteome #Proteoform #Proteoforms #Biotech

📰New & Featured | A study from #Cell discovered clear #proteome asymmetries between sister #blastomeres as early as the #2-cell stage
🔸#Alpha-Beta asymmetry is associated with developmental potential
🔸#Fertilization is a trigger for proteomic symmetry breaking in the #zygote

⏩Soutenance de #HDR de Mélisande Blein-Nicolas - GQE

📆 Jeudi 4 décembre 2025 à 13h

➡️ La relation génotype-phénotype : des approches réductionnistes aux approches holistiques basées sur la #protéomique

➡️ tinyurl.com/5t3j2z6h

#gqe #genotype #proteome #genetique @univparissaclay.bsky.social

This study demonstrates that #SNAI1 overexpression induces #Proteome alterations, #Nucleolar stress, #RibosomeBiogenesis, #Senescence, & activation of the #DNAdamage response, pointing to it as a potent therapeutic target in #KidneyFibrosis. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...

Molecular grammars of predicted intrinsically disordered regions that span the human proteome Grammars inferred using NARDINI+ (GIN) is a resource that uncovers molecular grammars of intrinsically disordered regions (IDRs) across the human proteome, revealing how distinct grammars underlie pro...

#Molecular grammars of predicted intrinsically disordered regions that span the human #proteome: Cell www.cell.com/cell/fulltex...

Predicting protein-protein interactions in the human proteome Protein-protein interactions (PPIs) are essential for biological function. Coevolutionary analysis and deep-learning (DL)–based protein structure prediction have enabled comprehensive PPI identificati...

This week #JournalClub @labsoap.bsky.social #proteome #AIscience www.science.org/doi/10.1126/...

Why is Nautilus data well-suited for AI workflows? Discover how Nautilus data is designed to provide direct and detailed measurements of single protein molecules that are well-suited for AI workflows.

Today on the Nautilus Blog - The second post in our new series focused on #AI and #proteomics. Dive in to learn how our data’s quality, simple and direct relationship to biology, and scale are designed to make it ideal for AI integration.

www.nautilus.bio/blog/why-is-...

#ML #Proteome

Iterative Mapping is our novel method for single-molecule protein and proteoform analysis across the full proteome.

Find us at #HUPO2025 to learn how you can use Iterative Mapping in your work:

nautilus-21430832.hs-sites-na2.com/meet-with-na...

#Proteomics #Proteome #Proteoform #Protein #Biotech

Why does proteomics need AI? The first post in our series on AI-readiness discusses why proteomics needs AI and why AI needs better proteomic data.

In our new blog series, learn how AI and #proteomics can combine to revolutionize biomedicine. Our first post in this series discusses:

Why proteomics needs AI and why we need better proteomic data to train models of biology

www.nautilus.bio/blog/why-doe...

#Proteome #MachineLearning

#Medsky🧪 #microsky A " #genome -to- #proteome map" is a molecular atlas that links specific genetic variants (in the genome) to their effects on the abundance & characteristics of proteins (the proteome).

Intrinsic heterogeneity of primary cilia revealed through spatial proteomics Primary cilia are critical organelles found on most human cells. Their dysfunction is linked to hereditary ciliopathies with a wide phenotypic spectru…

Article in Cell: Intrinsic heterogeneity of primary #cilia revealed through spatial proteomics #research supported by Knut and Alice Wallenberg Foundation #science #proteins #proteome @cellpress.bsky.social
tinyurl.com/578ej5uk

So proud and happy to share that our study on the #proteome, heterogeneity, and cell-type specificity of primary #cilia is published now at Cell 🎉

Big thank you to all the many people that made this possible, at the Lundberg Lab, Human Protein Atlas, Lindstrand lab, and Hsien-Sheu lab.

Applications of proteomics in cancer - Round up September 2025 ~ Nautilus Biotechnology Find Nautilus' latest applications of proteomics in cancer content focusing the impact proteoform analysis can have on cancer research

In the latest update to our Proteomics and cancer eBook, you'll find content focused on the incredible ways proteoform analysis can advance cancer research.

📘 Find the eBook here:

www.nautilus.bio/blog/applica...

#Proteoforms #Proteome #Proteomics #Cancer #CancerResearch #PrecisionMedicine

What drives science forward? People like Senior Automation Engineer Eloy Salinas, who is always on the lookout for ways to innovate in the lab.

Learn more about the IPI platform: buff.ly/91pXA1d

#proteinscience #proteome #labautomation #proteininnovation

Latest work from my lab at @uwaterloo.ca by PhD student Isaac Meza-Padilla on using #Alphafold for #proteome modelling in #cyanophages:

doi.org/10.1016/j.cs...

Q3 Track 1: Nautilus Biotechnology, Inc. - Investors Summit Group

In our latest investor presentation, Nautilus CEO Sujal Patel and Nautilus CFO Anna Mowry share why the world needs the Nautilus Platform to vastly improve #drugDevelopment and usher in a new era of #precisionMedicine.

investorsummitgroup.com/presentor/q3...

#Proteomics #Proteome #Proteoforms

In this work, we showed the capabilities of DarT by mapping the cell-surface #proteome of HeLa cells and putative #intracellular interactome of #CellPenetratingPeptides!

Nautilus at Morgan Stanley Conference: Proteomics Platform Unveiled By Investing.com Nautilus at Morgan Stanley Conference: Proteomics Platform Unveiled

We're redefining #proteomics through a single-molecule platform designed to quantify the entire #proteome and its myriad #proteoforms.

Read this interview with Nautilus CEO Sujal Patel to learn about our incredible progress and exciting plans for 2026!

www.investing.com/news/transcr...

Applications of proteomics in neuroscience - Round up September 2024 Find Nautilus' latest applications of proteomics in neuroscience content including blog posts, a new animation, and an updated eBook.

Our Iterative Mapping methodology is designed to provide clear, quantitative views of the #proteome. In our preprint, we used it to investigate the #proteoform landscape of #tau, a #protein deeply entwined with the mechanisms of #Alzheimer's.

Explore our insights:

www.nautilus.bio/blog/insight...

Large-scale CSF proteome profiling identifies biomarkers for accurate diagnosis of frontotemporal dementia - Molecular Neurodegeneration Diagnosis of Frontotemporal dementia (FTD) and its specific underlying neuropathologies (frontotemporal lobar degeneration; FTLD-Tau and FTLD-TDP) are challenging, and thus, fluid biomarkers are neede...

Large-scale CSF #proteome profiling identifies #biomarkers for accurate diagnosis of #FrontotemporalDementia

Yanaika S. Hok-A-Hin, Lisa Vermunt, Carel F.W. Peeters...Charlotte E. Teunissen & Marta del Campo @amsterdamumc.bsky.social #FTD

molecularneurodegeneration.biomedcentral.com/articles/10....

Elle travaille à l'IDEEV : Mélisande Blein-Nicolas, ingénieure de recherche à GQE Mélisande Blein-Nicolas jongle des protéines aux finances Mélisande Blein-Nicolas, vous êtes ingénieure de recherche INRAE à GQE-Le Moulon   . Quelles sont vos activités ? J’ai de nombreuses activités...

Mélisande Blein-Nicolas est ingénieure de recherche à #GQELeMoulon. Elle partage ses activités entre #PAPPSO, ses recherches et gestion financière

⏩ tinyurl.com/2vmp53z6

#proteome #proteine #gestion #ingenieure #analyseproteomique #gqe @inrae-france.bsky.social @cnrs.fr

Is single-molecule protein sequencing here yet? - Nature Methods As instruments and approaches emerge for single-molecule protein analysis, some developers and early users share their first impressions.

We're proud to be featured in this @natmethods.nature.com thods.nature.com article covering up-and-coming single-molecule #proteomics platforms!

www.nature.com/articles/s41...

We're developing an "entirely new measurement modality" & look forward to mapping the #proteome and #proteoform landscape.

Download Nautilus' Poster from AAIC 2025 Fill out this form download Nautilus Biotechnology's poster form AAIC 2025.

Interested in diving into our poster from #AAIC 2025? Sign up to receive a digital copy of the poster at the link below ⤵️

nautilus-21430832.hs-sites.com/download-nau...

#Proteomics #Proteoforms #Proteome #Neuroscience

Thus, we decided to overexpress #AluJB in primary IMR90 fibroblasts, and perform multi-omic profiling of its impact on the #transcriptome, #proteome and #secretome. We were surprised to see large scale multi-omic remodeling in response to #AluJB. 4/9

Development of a method for large-scale single-molecule analysis of tau proteoforms Proteins exist as diverse proteoforms resulting from a combination of genetic variation, alternative splicing, and post-translational modifications. Current methods struggle to capture this complexity...

We’ll be happy to answer any questions you have about our platform’s ability to quantify hundreds of tau proteoforms.

www.biorxiv.org/content/10.1...

#Tau #Alzheimers #AlzheimersResearch #Neurodegeneration #AlzheimersDisease #Proteomics #Proteome

Iterative Mapping provides in-depth views of proteoform groups Discover the benefits of proteoform group analysis by Iterative Mapping.

Learn how Iterative Mapping of proteoforms on the Nautilus Proteome Analysis Platform provides uniquely actionable views of the proteoform landscape:

www.nautilus.bio/blog/iterati...

#Proteomics #Proteome #Proteoform #Proteoforms #NextGenerationProteomics #Alzheimers #AlzheimersDisease

Ancient Rhino tooth helps push the boundaries of evolutionary research Scientists have shed new light on the rhino family tree after recovering a protein sequence from a fossilised tooth from more than 20 million years ago.

9-Jul-2025
Ancient #Rhino tooth helps push the boundaries of evolutionary research

https://www.eurekalert.org/news-releases/1090586

#science #proteome #fossil #ancientproteins #evolution

The latest Nautilus Newsletter is live!
nautilus-21430832.hs-sites.com/q2-2025-news...

In the newsletter you can... (1/6)

#NautilusBio #Biotech #Biotechnology #BiotechNews #Proteomics #Proteome #Neuroscience #AlzheimersDisease