I've recently made some changes to the gallery of all my data visualisations 📊

Most examples now have links to the underlying source code! If you see something you like, you can see how it was made 🤩

#DataViz #RStats

There were also mesangial IgA deposits (Figure 3), which likely explain the patient's hematuria and proteinuria, since there was very little glomerular amyloid (Figure 4).

#renalpath #kidneypath #pathology #renal #pathsky

The stain is a Congo Red viewed under fluorescent light with a red filter. It highlights interstitial amyloid deposits, which is the predominant pattern of deposition in LECT2 amyloidosis (confirmed by IHC stain, Figure 2).

#renalpath #kidneypath #pathology #renal #pathsky

This is the biopsy of a 62yo Hispanic female with hematuria and proteinuria. What is this stain and what is the diagnosis?

#DiagnoseThis #nephtwitter #pathtwitter #renal #kidneypath

A Randomized Trial of Targeted Hyponatremia Correction in Hospitalized Patients Chronic hyponatremia is associated with adverse outcomes, including falls, neurocognitive disorders, and mortality, but whether hyponatremia itself increases morbidity and mortality, or is simply a...

The HIT (Hyponatremia Intervention Trial) is finally out!
#hyponatremia #nephrology

evidence.nejm.org/doi/10.1056/...

Avacopan Causing Vanishing Bile Duct Syndrome in an Adult Patient With Microscopic Polyangiitis | Annals of Internal Medicine: Clinical Cases Microscopic polyangiitis (MPA) is a systemic necrotizing small-vessel vasculitis that may affect multiple organs. Avacopan, an oral complement (C5a) receptor inhibitor, was recently approved and recom...

Plus cases of Vanishing bile duct syndrome?

Eg www.acpjournals.org/doi/10.7326/...
And

academic.oup.com/rheumatology...

#NephSky #Vasculitis #Avacopan

What’s at Issue in the FDA’s Request to Withdraw Avacopan? European regulators are also conducting a review of avacopan. The issue appears to involve data from the pivotal ADVOCATE trial and questions of liver safety.

FDA asks Amgen (which bought Chemocentryx) for voluntary withdrawal of Avacopan

From January, with fresh Medscape coverage

Amgen www.amgen.com/tavneos-pres...

Medscape www.medscape.com/s/viewarticl...

- liver concerns
- BVAS scoring discrepancy from ADVOCATE

Kachel mit einem Zitat aus dem Beitrag von heise online: Anders als bisherige Systeme soll OLSPub ... eine echte Unabhängigkeit von der US-Infrastruktur gewährleisten.

Danke an @heise.de für die Berichterstattung über das Fundraising für OLSPub und die Einordnung der infrastrukturellen Dimension von Forschungssicherheit.

👉 Artikel: www.heise.de/news/Di...

👉 Mehr Infos: www.zbmed.de/forsche...

#OLSPub #ResearchInfrastructure #OpenScience #DigitalSovereignty

Here is today’s #eyeSCANdy! Acellular scanning EM showing a glomerulus with fibrocellular crescent (right).

Photo courtesy of Dr. Stephen Bonsib. #renal #pathology #kidneypath

The education and medical practice of Dr. James McCune Smith (1813-1865), first black American to hold a medical degree James McCune Smith (1813-1865)--first black American to obtain a medical degree, prominent abolitionist and suffragist, compassionate physician, prolific writer, and public intellectual--has been relatively neglected by historians of medicine. No ...

Reference: pmc.ncbi.nlm.nih.gov/articles/PMC...

To be honest, I think it is much more effective and safer to just learn analyzing venous blood gases directly.

The biopsy shows linear IgG staining along the GBM, and extensive fibrinogen staining within the Bowman space, consistent with crescent formation. These findings are diagnostic of anti-GBM disease.

#renalpath #kidneypath #pathology #renal

In a patient with AKI and hematuria, what is your diagnosis?

#DiagnoseThis #nephsky #pathsky #renal #kidneypath

(2/2) ...ANCA-related disease (esp. medullary hemorrhage), trauma, underlying coagulopathy, and, in the transplant setting, both T-cell and antibody-mediated rejection.

The differential diagnosis for interstitial hemorrhage includes hemorrhagic necrosis in the setting of renal artery thrombosis, infection (e.g. herpes simplex virus, adenovirus, hantavirus, Rickettsia),...(1/2)

#TeachingPoints #kidneypath #renal #pathology

5 Things We Learned About Journal Peer Review in 2025 - Absolutely Maybe Back in 2019 I wrote a couple of posts summarizing what we had learned from research about peer review at journals. Since…

Lots to think about in my annual roundup of peer review research:
- AI, mostly bad; some suggestions of ways it may help
- Evidence on financial rewards for peer review
- Influence of editors' biases
More on equity & diversity; librarians & systematic reviews
absolutelymaybe.plos.org/2026/02/02/5...

Study is stolen, sold, published. Now the victim is accused of plagiarism The year 2026 did not start off kindly for Vijayalakshmi S, an economics researcher at RV University in Bengaluru, India. She received a rejection letter from a journal noting that a paper of hers …

telegram-based paper mill

retractionwatch.com/2026/01/26/s... on @retractionwatch.com

$165 for first author,
$110 for second author,
and $55 for the remaining slots

welcome to academic publishing!

To the Editor: As physicians, we took an oath to care for others and to do no harm, promising, in part, “I will remember that I remain a member of society, with special obligations to all my fellow human beings.” The mandate primum non nocere — first, do no harm — has been ingrained in us since medical school. So here we stand, compelled to share our stories in this moment, so the rest of the country knows what is happening in our state. We are bearing witness to what fear can do to the health of a community. Regardless of whether we have lived here our whole lives or moved here from the other side of the world, we all call the beautiful state of Minnesota our home. We live in big cities, in suburbs, and in rural areas. We work in large health systems, in private practices, at academic health centers, in the VA Health Care System, in federally qualified health centers, and with the Indian Health Service. We care for patients throughout our state from birth to death. We teach the next generation of physicians. In a powerful article in the Journal last spring, Drs. Alice T. Chen and Vivek H. Murthy called on physicians to use their voices to advocate for the health of patients and communities during dangerous times.1 In Minnesota, we have found ourselves in an extraordinarily dangerous time. As the presence here of Immigration and Customs Enforcement (ICE) has increased, our clinic schedules have filled with missed appointments. Patient volumes have plummeted in our emergency departments (EDs). Each of these missing patients represents a lost opportunity: a chance to intervene, to make a diagnosis, to start or alter treatment, or to turn the tide of chronic illness. These aren’t patients who don’t care. These are patients who are terrified. When we call to check on them, they tell us they are scared to leave their homes. Scared to drive. Scared to take a bus. Scared that a walk across a parking lot to clinic — a place meant to heal — could put them and their families …

We also know the mental health impact of this crisis. Political unrest and the unfair targeting of immigrant communities have deepened fear, grief, and division, and we see the emotional toll every day. Patients are presenting with symptoms of post-traumatic stress disorder, with suicide attempts. We sit with people whose loved ones have been detained, families fractured, and communities shaken by uncertainty and loss. Our hearts break for all of them. These are not abstract issues in a news cycle — they are human lives, families, and communities hurting in very real ways. Holding space for this pain has reminded us that suffering affects us all. Fear, grief, and exhaustion cross political and cultural lines. We are not immune simply because we are physicians. Dread, desperation, and isolation tighten their grip day by day. We are devastated to witness a beloved nurse colleague, Alex Pretti, gunned down by federal agents. Some of us step out of our homes to provide care for the people of Minnesota knowing that today might be the day when the amount of melanin in our skin outweighs the degrees we have earned and the people we have healed. And yet we push forward, doing what we can. We make calls to patients, attempting to manage what we can from afar. But too often the calls go unanswered. Are our patients afraid to pick up? Or are they unable? We make covert home visits, organize emergency hotlines. We deliver medications, food, and diapers to those who cannot safely leave their homes. When patients do come to see us, we ensure that they leave with enough medication to (we hope) survive this crisis. We are trained to respond to emergencies. We are trained to go above and beyond in moments of crisis. Whether that means working longer hours tending to the sick or linking arms with vulnerable colleagues to walk them to their cars, we help however we can. Nevertheless, we struggle against feelings of helplessness, especially when we are not allowed to help. We read the …

The @nejm.org publishes this from the Minnesota Physicians Voices

www.nejm.org/doi/full/10....

#KidneyWk used to be a highlight of my year and I was really proud to support @asnkidney.bsky.social .
Its tacit acceptance of Donald Trump and his actions has been a major disappointment for me.
So, yes …👇

Five compelling reasons to submit to Kidney International Case Reports™   - International Society of Nephrology

5 reasons to publish with KICR

www.theisn.org/blog/2026/01...

@theisn.org @arvindcanchi.bsky.social

#NephSky

#NephMadness 2026: Meet the Gamemakers

bit.ly/3Nk10Ap

What are your differential diagnosis for this ultrastructural finding?

#DiagnoseThis #nephx #pathx #renal #kidneypath

Got Milk? It’s a Tricky Question for Renal Patients Renal diets with limits on protein, potassium, phosphorus, calcium, and sodium make milk choices baffling. Knowing the pros and cons of a variety of milks can help take the guesswork out of breakfast.

Nice blog post about the various milk options and what they offer kidney patients:

www.medscape.com/viewarticle/...

Science Populism, Medicine Style - Absolutely Maybe I hadn’t been aware of the term science populism until a video about it did the rounds recently. It was a light-bulb…

Food for thought

Science populism, EBM and influencers

absolutelymaybe.plos.org/2025/12/19/s... from @hildabast.bsky.social

#KPMP is ending 2025 on a high note with our Q4 2025 Kidney Tissue Atlas Release dropping today 🥳🎉 What are you waiting for? Go check out the explorer, repository AND spatial viewer release highlights!

atlas.kpmp.org

#Kidney #Atlas #Nephrology #PrecisionMedicine #OpenAccess #Data #PublicData

Explore the KPMP Kidney Tissue Atlas today

🔍 Search markers
🧬Download raw gene data
🗺️Explore spatial data

Openly accessible and designed to support discovery

🔗 atlas.kpmp.org

#KPMP #KidneyResearch #OpenScience #KidneyTissueAtlas

#Alport Syndrome is a Partial #Tubulointerstitial Disease of the #Kidney

#VisualAbstract by @Husamjz

www.kireports.org/article/S2468-0249(25)00...

GFR Measured With Computerized Tomography Urography in Healthy Individuals and Patients With CKD - American Journal of Kidney Diseases www.ajkd.org/article/S027...

Highlights from my talk yesterday on Alport syndrome spectrum of disorders. (since no one posted it, I'll have to do it myself)

Variants in type IV collagen cause a wide spectrum of disease. #KidneyWk 🧵

Nephrologists deported
Grants defunded
NIDDK folded into National Institute of body parts
AHRQ demolished
Now this…

When are our organizations going to speak up?

#NephSky