Really honored to be named a 2026 Ohio State Distinguished University Professor. Thank you to my mentors, trainees, and collaborators for all the support and encouragement. faculty.osu.edu/news/2026/04...
Out now at PLoS Pathogens @plos.org. Nice collaboration with @danielhurdiss.bsky.social @utrechtvirology.bsky.social. Some beautiful glycoproteomics work by @tshamorkina.bsky.social mapping N- and O-glycan shield of coronaviruses infecting whales and dolphins 🐋🐬🐳.
journals.plos.org/plospathogen...
We're excited to announce the beta-release of #RELION-5.1! 🥳 This release has important updates on our #amyloid processing pipeline, as described in this preprint: doi.org/10.64898/202... There are also some tweaks for #teamtomo.
#OpenSoftwareAcceleratesScience
Repeated COVID-19 vaccine boosters elicit variant-specific memory B cells in humans @cp-cellreports.bsky.social
www.cell.com/cell-reports... @veeslerlab.bsky.social
🚨 new paper alert 🚨
Here we demonstrate increased anti-RBS neutralizing responses elicited by stabilized influenza H5 immunogens:
bit.ly/4u8UxJl
Big thanks to Aakanksha @singhvilabglia.bsky.social for the nomination, to J. Bai and @nlehrbach.bsky.social for supporting it, to A. Calixto, S. Karimzadegan, P. Gurung, J. Cattin-Ortola, M. Crawford, for their supportive letters and to all my mentees for making this job colorful and meaningful ♥️
In new study led by Brendan Larsen, we map functional constraint across the Nipah virus F protein to define constrained epitopes for antibody targeting and identify mutations that stabilize the prefusion conformation for vaccine immunogens.
www.pnas.org/doi/10.1073/...
In new study we examine constraints on evolution of endemic "common-cold" coronavirus 229E
We find strong tradeoff between antibody neutralization & receptor binding, due to up-down position of spike RBD
www.biorxiv.org/content/10.6...
See lead author Sheri Harari's summary: x.com/SheriHarari/...
Our latest paper shows that IFITM3 deficiency allows SARS-CoV-2 to adapt more easily to a new host species. Mouse-adapted beta and omicron variants from this work maintained their unique tropisms and pathogenic characteristics allowing exciting comparative studies.
www.nature.com/articles/s41...
As Fran was nice enough to highlight this, I thought I'd put up a brief thread. 3 in 10 proteins that our cells make are either embedded in membranes (ion channels, adhesion molecules, etc.) or secreted (insulin, antibodies). They move through the secretory pathway.
1/
We studied how the glycan shield of alphaherpesvirus fusion protein gB mediates host co-receptor interactions. Great work by Sabrina, check it out!
www.biorxiv.org/content/10.6...
Our paper on the role of #SARSCoV2 NSP3 in stress granule control is now out in JVI.
Reposting our original BioRXIV thread on the summary.
journals.asm.org/doi/10.1128/...
Potent neutralization of Marburg virus by a vaccine-elicited antibody
www.nature.com/articles/s41...
Potent neutralization of Marburg virus by a vaccine-elicited antibody @nature.com @hhmi.org @veeslerlab.bsky.social @virbiotechnology.bsky.social
www.nature.com/articles/s41...
Delighted to share the peer-reviewed version of our article describing a prefusion-stabilized MARV GP vaccine immunogen and a best-in-class MARV neutralizing and protective antibody!
Led by @aminaddetia.bsky.social with @virbiotechnology.bsky.social
@hhmi.org
www.nature.com/articles/s41...
Since early 2024 we have been working with @brukercorporation.bsky.social on the first prototype timsOmni instrument, integrating an Omnitrap into a timsTOF. Here we report for the first time on the use of this instrument for protein-centric antibody sequencing. See www.biorxiv.org/content/10.1...
Mysteries of trafficking of the vRNP segmented genome and assembly of influenza A virus revealed by in situ cryo-ET!
🔗 rdcu.be/eMmct
We are very excited that our paper is finally out!
🎉 Big congratulations to Moritz Wachsmuth-Melm and to everyone involved.
Our latest work on #COVID immunity and imprinting in humans.
Led by Ale Tortorici and Kaiti Sprouse with @aminaddetia.bsky.social and several others!
www.biorxiv.org/content/10.1...
Now out in Science! Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle. In @vcushing.bsky.social's magnum opus, we use #cryoEM to figure out how the CDK-activating kinase recognises CDKs to fully activate them - a key step in cell cycle control.
www.science.org/doi/10.1126/...
Congratulations Jason! This is awesome
Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, Christian, @sokrypton.org, Bruno and many other amazing lab members and collaborators.
www.nature.com/articles/s41...
I am excited to share our latest preprint presenting the structure of human NHE6, a key endosomal Na⁺/H⁺ exchanger involved in Christianson syndrome.
We bring together #cryo-EM, NMR, SAXS, lipidomics, and functional assays for an integrative analysis of NHE6 architecture, function, and regulation.
We sequenced the anti-RSV-F antibody 131-2a by mass spec and determined its epitope by cryoEM. New insights in postfusion specific binding and antigenic site I. Now published in ACS Infectious Diseases @pubs.acs.org.
pubs.acs.org/doi/10.1021/...
@xdh.bsky.social @hangryhobbit.bsky.social
Our entrance into protein design! Inverse folding steered by external sources of information, and for multiple conformations. By the amazing @kaiyi94.bsky.social and @kjamali.bsky.social!
Download our code and try it yourself. 🥳
Important insights into FCoV-23 cell entry from the @veeslerlab.bsky.social
Freely available: www.nature.com/articles/s41...
Loss of FCoV-23 spike domain 0 enhances fusogenicity and entry kinetics pubmed.ncbi.nlm.nih.gov/40634609/ #cryoEM
Our paper describing how in-host evolution of a recently emerged, highly pathogenic coronavirus modulates entry into cells, membrane fusion and likely pathogenicity has now been published in its peer-reviewed form!
Led by Ale Tortorici!
@hhmi.org
www.nature.com/articles/s41...
Our effort to try to do something for [cystic fibrosis (CF)] started as a basic science enterprise. That was a hard slog back in the 1980s. Nobody would have supported except NIH. Now, 30 years after that discovery, young people with CF get to plan for retirement instead of an early funeral.
Congratulations @stanford-chemh.bsky.social Institute Scholar @cobarnes27.bsky.social on being named a 2025 Freeman Hrabowski Scholar @hhmi.org 🎉 🍾
www.hhmi.org/programs/fre...
I have exhorted others to share positive news even in these uncertain times for US science.
I am really excited that @tamanash.bsky.social’s first paper on the remarkable evolutionary gymnastics of dual-host viruses (even in single codons) is now online.
Follow along here 🧪🧵
