Kelis!

One week left to apply for the EMBO/FEBS lecture course on #ionchannels and #transporters in beautiful Erice in May 2026:

meetings.embo.org/event/26-ion...

Please share

Cryo-EM structures of human P2X2/3 heteromer channel reveal the structural basis of ligand selectivity pubmed.ncbi.nlm.nih.gov/41931608/ #cryoEM

Excited to be on my way to the Ligand Recognition and Molecular Gating GRC - many of our present projects started at this meeting 10 (!) years ago!
@Nalcn @Split inteins

New OpenFold3 preview out! (OF3p2)

It closes the gap to AlphaFold3 for most modalities.

Most critically, we're releasing everything, including training sets & configs, making OF3p2 the only current AF3-based model that is functionally trainable & reproducible from scratch🧵1/9

Keep calm and be transparent: advice from scientists who retracted their papers Retractions correct the scientific record, but they have stigma attached to them. Some in the research community want that to change.

Keep calm and be transparent: advice from scientists who retracted their papers www.nature.com/articles/d41... @elisabethbik.bsky.social

Lab Management Software | Laboratory System | Labguru Accelerate R&D with unified lab management software. Let your lab teams collaborate, track experiments, and search results in the laboratory system.

Yes, we use www.labguru.com for inventory and as our electronic lab book (through an institutional account)

3000th clone added to our clone library. Happy weekend

I’m with you on this 😭

Sudha (@chakrapanilab.bsky.social) and Julio (@cvlab.bsky.social) are organizing the 2026 Ion Channel Gordon Research Conference: Ion Channels Across Scales — Bridging Molecular Events to Physiological Outcomes, to be held at Mount Holyoke College, July 12–17, 2026.

1/3

Kicking off 2026 on a positive note!
Check out our latest work on developmental channelopathies.
#IonChannels #NALCN #IHPRF1

Time to sign up!

Registration for the joint FEBS/EMBO course on ion channels and transporters in Erice, Italy (May 13-19th 2026) is now open:
meetings.embo.org/event/26-ion...

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Lorne Proteins 2026 🏖️ Leach Lecturer Carol Robinson, Oxford, on establishing mass spec as a viable technique for structure/function studies; and John Kuriyan, Vanderbilt University, on the structural plasticity and evolutionary potential of DNA clamp loaders.

🔗 Register now: www.lorneproteins.org

The commitments in the SAFE Labs Handbook.

A new community-driven lab handbook for reducing conflict and creating more positive and equitable work environments gets strong support from a survey of 200 researchers.
buff.ly/K7CGFLV

So sad. I love his work.

To all trainees interested in channels and transporters: the joint FEBS/EMBO course will go ahead in Erice, Italy from May 13-19 2026:
network.febs.org/posts/new-jo...
Further details to come soon.

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PhD students and Postdocs: The Night Science Podcast (@nightsciencepod.bsky.social) is producing an episode highlighting young scientists talking about their creative process. DM me if you'd like us to consider you for this, & read below what PhD student Davis Garner will contribute! ⬇️

Game changer, no doubt. Commercial systems will have expensive consumables I suppose, but huge savings to be made in cell culture, and many important but sparse native targets come into play.

Crispr-tagged targets from iPSC neurons, for example.

TRPC6 blind? 🤯

Congratulations to everyone involved in this amazing project!

Very grateful to have been able to attend the second-ever NALCN conference. This provided a fantastic opportunity to catch up with collaborators and meet patients and families affected by NALCN-related diseases. Huge thanks to everyone at the Channeling Hope Foundation for making this event happen!

Phosphorylation on tyrosines control key pathways in immunity, cancer, and metabolism. For the first time, we can now design proteins that specifically recognize individual phosphotyrosines, even in disordered regions. (1/8)

Preprint: www.biorxiv.org/content/10.1...

When I started working on ion channels 20+ yrs ago, I could have never imagined how many channels there are to explore! Now I’m delighted to be heading to thematic meetings on two of our favorite channels in the span of just weeks - can’t wait to catch up with the ASIC and NALCN communities!

Thanks so much for contributing to this!!

A huge thank you to everyone involved and of course @lundbeckfonden.bsky.social, @carlsbergfondet.dk and DFF for funding.

Collaborator @amelierocks.bsky.social complemented this with predictions of protein stability and conservation scores. In combination with functional work this establishes a framework for classifying suspected disease variants, which we hope will aid assessment of NALCN variant pathogenicity

@chowhanchua.bsky.social implemented use of a combination of multiple parameters derived from two-electrode voltage-clamp electrophysiology recordings. These allow us to classify LoF and GoF phenotypes and to provide mechanistic insight into the molecular mechanism underlying specific variants.

De novo and inherited NALCN variants can lead to severe developmental syndromes. Although variants of uncertain significance or presumed pathogenic variants have been studied in heterologous systems before, there is no generally accepted framework on how to assess or predict variant pathogenicity.

After years in making, I am glad to be able to share our attempt on establishing a framework for combined functional and computational assessment of variant pathogenicity in the sodium leak channel NALCN:
www.biorxiv.org/content/10.1...

Momentum is building! Join us for the 51st Lorne Proteins Conference Feb 8–12, 2026, Mantra Lorne on the Great Ocean Road, for fun networking activities 🏐 🎾 🥗 🪩 and breathtaking surf-coast accessibility 🏖️ 🏊 🏄 in the generous breaks between sessions!

🔗 Register here: www.lorneproteins.org/register

Come to the second edition of the world wide sodium channel conference! Submit an abstract by September 26.