About one quarter of the 20659 proteins in the human proteome have TMDs. Most have 1 TMD, there's about 1000 with 7 TMDs. Details are in the post, which is linked.

How many proteins in the human proteome have transmembrane domains? And of those, how many examples with n TMDs are there?
Couldn't find an answer, so I calculated it from Uniprot data with some #RStats magic (and I did some model organisms while I was at it). 🧪

quantixed.org/2026/04/16/m...

Glad to hear it's not just us! I always have to image red then green.

Lovely!

Stereotypical interciliary contacts in a C. elegans sense organ www.biorxiv.org/content/10.64898/2026.04...

That spermatheca looks so cool.

A star scientist showed that better genetics lessons could reduce racism. It was the death knell for his career Brian Donovan had persuaded high school teachers and education researchers that prejudice might be ended by changing how genetics is taught.

“We’ve lost out on the ability to continue to improve this work to make it more effective, and to explore how to apply it to other areas…There are a lot of different ways that genetics has been used to justify prejudice and…that human-made social categories interface with biological categories“🧪

Guangshuo Ou's lab is a powerhouse. Here they create a C. elegans mutant collection to model human disease variants of uncertain significance.

The limitation section raises the challenge of storing & sharing strains. The NIH funds the CGC. How can we build international resources w/cost sharing?

Using EMS mutagenesis, authors generated & sequenced 12,069 viable C. elegans strains, identifying 541,102 missense mutations. They developed TaoChongBao, an open-access database integrating mutation data, greatly expanding functional variant resources. www.life-science-alliance.org/content/9/6/...

Image of News in focus article from Nature entitled "How bioRxiv changed the way biologists share ideas - in numbers"

The impact of bioRxiv in numbers

@richardsever.bsky.social

I've submitted my abstract!

Abstract submission deadline extended to Monday, February 16, 23:59 hrs CET (no exceptions). Last chance to submit an abstract for inclusion in the programme of #eshg2026 #hybridconference! More information on: 2026.eshg.org/abstracts/

This makes me want to get to the lab and inject some worms!

These strains just arrived from CGC! Very exciting!

The Caenorhabditis Genetics Center Curated Special Collections: a guide to protein degradation systems Abstract. The Caenorhabditis Genetics Center is launching a new website feature—“Curated Special Collections”—designed to help researchers navigate the eve

The Caenorhabditis Genetics Center Curated Special Collections: a guide to protein degradation systems

academic.oup.com/genetics/adv...

𝗠𝗲𝗲𝘁 𝗼𝘂𝗿 𝗸𝗲𝘆𝗻𝗼𝘁𝗲 𝘀𝗽𝗲𝗮𝗸𝗲𝗿𝘀 𝗳𝗼𝗿 #𝗖𝗶𝗹𝗶𝗮𝟮𝟬𝟮𝟳!

We are grateful for their participation and look forward to welcoming the cilia community on 8-12, March 2027.

Wishing you all a happy and inspiring 2026! 🎉

#Cilia #Milan

Three people discharged from hospital after chemical spill at Trinity College Dublin Incident took place at Trinity Biomedical Sciences Institute on Tuesday morning

Yikes! Glad everyone is okay. Lab safety is no joke.
www.irishtimes.com/ireland/educ...

You should be able to respond to reviewer comments with memes to liven up the peer review process.

Works great on my computer!

Unfortunately I couldn't get the website to work on my phone. Love the idea of this resource.

Im considering a human genectics conference for next year. Do any C. elegans researchers go to the ASHG or ESHG meetings?

We built this site to allow you to probe our single-nucleus RNA-seq data for adult #Celegans neurons (wt & daf-2 herms, and wt males v herms): cestaan.princeton.edu
and a microPub about how to use it: www.micropublication.org/journals/bio...
We hope the #Celegans community finds it useful! 🧪

Beautiful images like this make me consider working on muscle 😍

New must-read review article for all lovers of #centrioles and #centrosomes 😍👇

#worms #celegans

Removal of the Ciliary Gate Allows Axoneme Extension in the Absence of Retrograde IFT The transition zone (TZ) is a selective barrier that maintains ciliary compartmentalization by controlling protein entry and exit. Cilia assembly requires the crossing of this barrier by intraflagella...

I clicked this link so fast! Right up my alley.

Removal of the Ciliary Gate Allows Axoneme Extension in the Absence of Retrograde IFT

www.biorxiv.org/content/10.1...

Dias Maia Henriques, Dumont, Maton et al. @ijmonod.bsky.social uncover an #anaphase A pathway, driven by the #kinesin-13 KLP-7 and opposed by the kinesin-12 KLP-18, that contributes to chromosome segregation in early #Celegans embryos. rupress.org/jcb/article/...

#Mitosis #CellDivision #Spindle

European C. elegans meeting!

ceneuroeuro2026.sciencesconf.org

Congratulations on your first first-author paper!!!! Good luck tomorrow.

Lovely work by @emiliafil.bsky.social looking at how septins affect cilia in worms

In #GENETICS, @jsrinivasanwpi.bsky.social and the team present a rescue-by-feeding approach, showing that feeding engineered E. coli containing neuropeptides to #Celegans mutants can successfully rescue behavior defects in worms. buff.ly/Qdw9Nsq