Shouya’s amazing efforts have provided functional validation of many reported variants of (previously) unknown significance in the #NLRP3 #inflammasome, not only uncovering interesting aspects of NLRP3 biology, but also hopefully leading to improved diagnosis and treatment of patients with CAPS!

Congratulations to @shouyafeng.bsky.social @sethlucianmasters.bsky.social and the entire team on our lab’s latest publication out now in @natimmunol.bsky.social!
#autoinflammation #autoinflammatory

Emerging concepts and treatments in autoinflammatory interferonopathies and monogenic systemic lupus erythematosus - Nature Reviews Rheumatology This Review provides a comprehensive update on dysregulated type I interferon production and signalling in autoinflammatory interferonopathies, monogenic systemic lupus erythematosus and conditio...

#JanuaryIssue | Emerging concepts and treatments in autoinflammatory interferonopathies and monogenic systemic lupus erythematosus

Goldbach-Mansky and colleagues propose a pathogenesis-based classification of #autoinflammatory interferonopathies in this #Review

bit.ly/4gLCpOx

Looks like a great inflammazoom coming up Dec 16 with @inflammasomelab.bsky.social and Si Ming Man! These talks are great for everyone interested in autoinflammation.

Register here to access the live session as well as on-demand talks from past sessions: events.abcam.com/AnYVL?rt=Qlp...

Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells Nature Immunology - Pyroptotic cell death results in inflammation. Here the authors find that F-actin-rich structures formed during macrophage pyroptosis persist after cell death to activate...

Have you ever wondered whether pyroptotic corpses have functions beyond the grave? We made the surprising discovery that pyroptotic corpses are flagged by #filopodia to alert #DendriticCells they need autopsy. A short Bluetorial (1/13)👇with movies!
Link: rdcu.be/d2mjm

Thanks Matt! Our semi-regular debriefs all along the way were invaluable!

Thanks Natalia!

Thanks to all of our amazing coauthors including @kerryhilligan.bsky.social, @danbarberphd.bsky.social for spending many, many hours tolerating me in the BSL3 lab, helping with experiments and data analysis, and providing valuable advice and moral support!

More details in this 🧵 from my powerhouse PI @mayerbarber.bsky.social whose foresight and guidance got us to this fantastic manuscript!

The inflammatory microenvironment of the lung at the time of infection governs innate control of SARS-CoV-2 replication Recent or ongoing respiratory inflammation in the lung regulates antiviral immune responses to SARS-CoV-2.

Excited to share this paper from my post-doc at @niaidnews.bsky.social out now in Science Immunology! We show that recent or ongoing 🫁 infections or other pulmonary environmental exposures at the time of infection with SARSCoV2 can vastly influence early replication of the virus in mice.

This month’s cover features an adult female Hpb in the center, flanked by adult Hpb males with their characteristic caudal bursae on the left and right sides, crescent-shaped Hpb larvae from various stages surrounding the adults, and Hpb eggs in the four corners of the image.

The December issue of #Science #Immunology is out now! This week: #MAITcell plasticity in #antibacterial immunity; how #inflammatory status of #lung before #COVID19 infection impacts #viral control; & #helminths utilize glutamate dehydrogenase to prevent #AAMs & #TH2 activation!

bit.ly/SI_DEC_24