Mucosal‐Associated Invariant T Cells: Origins, Biological Functions, Diseases, and Therapeutic Targets Mucosa-associated invariant T (MAIT) cells are an evolutionarily conserved class of innate-like T lymphocytes that rely on MR1 molecules to recognize microbial metabolites and play a central role in ...

#Review in #MedComm
Mucosal-Associated Invariant T Cells: Origins, Biological Functions, Diseases, and Therapeutic Targets doi.org/10.1002/mco2...

#AutoimmuneDisease #cancer #Immunotherapy #InfectiousDisease #MAITcell #MR1 #UnconventionalTcell #MAIT

Kaiwen Zhu, Yan Lu, André Veillette et al. @ircm.bsky.social show that the interplay between CD2 and its ligands is pivotal for #MAITcell development and activation, highlighting potential approaches for treating human diseases implicating #MAITcells. rupress.org/jem/article/...

Zhu, Lu, Veillette et al. @ircm.bsky.social show in @jem.org that CD2 & its ligands regulate #MAITcell development and antigen responses by enhancing TCR signaling. A natural subset of human MAIT cells lacking CD2 exhibits reduced activation responses to antigen. rupress.org/jem/article/...

Kaiwen Zhu, Yan Lu, André Veillette et al. @ircm.bsky.social show that CD2 & its ligands regulate #MAITcell development and antigen responses by enhancing TCR signaling. A natural subset of human MAIT cells lacking CD2 exhibits reduced activation responses to antigen. rupress.org/jem/article/...

And from National University of Ireland Maynooth (NUIM), Eimear Ryan from @andyhogan82.bsky.social lab will present her work at the December @immunometforum.bsky.social on #MAITcell #metabolism.

#immmunosky #immunoology #immunometabolism

This month’s cover features an adult female Hpb in the center, flanked by adult Hpb males with their characteristic caudal bursae on the left and right sides, crescent-shaped Hpb larvae from various stages surrounding the adults, and Hpb eggs in the four corners of the image.

The December issue of #Science #Immunology is out now! This week: #MAITcell plasticity in #antibacterial immunity; how #inflammatory status of #lung before #COVID19 infection impacts #viral control; & #helminths utilize glutamate dehydrogenase to prevent #AAMs & #TH2 activation!

bit.ly/SI_DEC_24

Great trip to Montpellier for French Innate T cell meeting! Happy to share our latest #MAITcell metabolism work & catch up with friends from Sweden & France